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Tolterodine

Uses of Tolterodine

  • Tolterodine is primarily used to manage symptoms of overactive bladder (OAB) and belongs to the class of medications known as antimuscarinics or antispasmodics.

  • This medicine is beneficial for managing urinary urgency, urinary frequency and urge incontinence, which are common symptoms of OAB. It can significantly improve these symptoms and enhance the quality of life for individuals with OAB.

Side effects of Tolterodine

  • Dry mouth

  • Constipation

  • Headache

  • Dizziness

  • Blurred vision

How Tolterodine works

  • Tolterodine belongs to the class of medicines known as antimuscarinics or antispasmodics.

  • It functions as a competitive muscarinic receptor antagonist. This means it binds to the muscarinic receptors found in the bladder's detrusor muscle, blocking a substance called acetylcholine. The blockage of acetylcholine leads to the relaxation of the detrusor muscle, which is the muscle responsible for bladder contraction during urination. This relaxation increases the capacity of the bladder and reduces its involuntary contractions. As a result, Tolterodine helps reduce sudden urges to urinate and episodes of urine leakage, also known as urge incontinence.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Tolterodine can be taken orally (immediate-release tablet and extended-release capsule).

Age and Dose Restrictions

  • Tolterodine is indicated for use in adults and elderly patients.

Contraindications

  • Tolterodine should not be used by individuals with known hypersensitivity to tolterodine or to any of the other ingredients. It is also contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and severe liver impairment.

Other Medications to Avoid

  • Tolterodine may interact with anticholinergic medications (such as oxybutynin and solifenacin), antibiotics that inhibit CYP3A4 enzymes (such as erythromycin and clarithromycin), as well as antibiotics that induce CYP3A4 enzymes (like rifampin).

Overdose and Missed Dose

  • An overdose of tolterodine may lead to severe side effects like blurred vision, difficulty urinating, and fast heartbeat. If you observe these symptoms, inform your doctor immediately.

  • If you miss a dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed one. Do not double up doses to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing Tolterodine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For managing dry mouth, try sipping water frequently.

  • If you have constipation, increase your intake of fibre and fluids.

Use in Driving and Operating Machinery

  • Tolterodine may cause drowsiness or blurred vision. If you experience these side effects, avoid driving or operating heavy machinery until you are sure this medicine does not impair your ability to carry out these activities safely.

Use in Pregnancy and Lactation

  • Tolterodine should only be used during pregnancy if clearly necessary. Caution should be exercised when administered to nursing mothers.

Caution in Other Conditions

  • Patients with moderate to severe liver impairment or decreased kidney function should exercise caution when using tolterodine.

  • Individuals with a condition known as myasthenia gravis should also use this medication with caution.

Special Dietary and Lifestyle Recommendations

  • It may help to avoid caffeinated drinks such as tea, coffee, and cola as they can aggravate your symptoms.

  • Aim to drink 6 to 8 glasses of water a day (unless the doctor advises otherwise).

  • Training your bladder can help manage the symptoms of an overactive bladder. This involves gradually extending the time between visits to the toilet.

Frequently asked questions

While it is rare, some individuals may experience changes in mood or behaviour due to Tolterodine. This can include confusion or hallucinations. If you notice any changes in mood or behaviour while taking this medicine, please consult your doctor.

There is no evidence to suggest that Tolterodine has a significant impact on appetite. However, individual responses may vary and if you notice any unexpected changes in appetite or weight while taking this medicine, do consult your doctor.

Tolterodine should only be taken for as long as your doctor advises. While it has been used safely for long-term treatment in some cases, it's important to have regular medical reviews to monitor its effectiveness and check for any side effects.

Tolterodine is a prescription medicine and should only be used under the supervision of a doctor.

If you have an allergic reaction to Tolterodine (symptoms may include rash, itching, difficulty breathing, swelling of your face, lips, tongue or throat), stop taking the medicine and seek immediate medical help.

No substantial evidence suggests that Tolterodine has any significant impact on the menstrual cycle in women. If you notice any unusual changes in your menstrual pattern while taking this medicine, please consult your doctor.

The composition of the medicine, including its inactive ingredients (excipients), determines whether it is vegetarian-friendly. It is recommended to read the leaflet provided with the medication or consult your pharmacist or doctor to confirm this.

Terms & Conditions


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