Trazodone
Uses of Trazodone
The primary use of Trazodone is for the management of major depressive disorder (MDD) in adults, and it belongs to the class of serotonin modulators.
Besides its main application for MDD, doctors also prescribe Trazodone to manage insomnia, anxiety disorders, chronic pain conditions like fibromyalgia and neuropathy, alcohol dependence, and Alzheimer's-related agitation and behavioural disturbances.
Side effects of Trazodone
Drowsiness and fatigue
Dizziness or lightheadedness
Dry mouth
Blurred vision
Constipation
How Trazodone works
Trazodone belongs to the category of medicines known as serotonin modulators.
It primarily functions by altering the levels of serotonin, a chemical messenger in the brain that plays significant roles in regulating mood, emotions, sleep, and pain perception. Trazodone works by blocking the reuptake of serotonin, thus elevating its activity at the serotonin receptors, specifically the 5-HT2A and 5-HT2C types. This overall increase in serotonergic activity is considered responsible for Trazodone's antidepressant, anxiety-reducing, and sleep-enhancing effects.
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Expert Advice
Dosage Forms Available
Trazodone can be taken orally (tablet).
Age and Dose Restrictions
This medicine is intended for use in adults aged 18 and above.
Contraindications
Trazodone is contraindicated in patients with known allergies to trazodone. The medicine should not be used by patients with liver or kidney disease, a history of heart attack or stroke, or those with a history of medicine or alcohol misuse.
Other Medications to Avoid
Trazodone may interact with monoamine oxidase inhibitors (such as phenelzine and tranylcypromine), antidepressants (like fluoxetine, duloxetine), antipsychotics (such as haloperidol, risperidone), benzodiazepines (like diazepam, lorazepam) and certain antibiotics (like erythromycin, clarithromycin).
Overdose and Missed Dose
An overdose of Trazodone may cause drowsiness, vomiting, irregular heartbeat or seizures. If you suspect an overdose, immediate medical attention should be sought.
If you miss a dose of Trazodone, take it as soon as you remember unless it is close to the time for your next dose. In this case, skip the missed dose and continue with your regular dosing schedule. Never double your dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless, resolving on discontinuation of the medicine. However, if you experience any severe side effects or worsening symptoms, consult your doctor.
Drinking plenty of water may help manage dry mouth associated with this medicine.
Taking Trazodone at bedtime may lessen the side effects of drowsiness and fatigue.
Use in Driving and Operating Machinery
Trazodone may cause drowsiness, dizziness or blurred vision. It is advised to avoid driving a vehicle or operating heavy machinery until you know how the medicine affects you.
Use in Pregnancy and Lactation
It is advised to consult your doctor before using this medicine during these periods.
Caution in Other Conditions
Caution is advised when using Trazodone in patients with heart disease, as it can cause changes in heart rhythm. Patients with a history of bipolar disorder should also take caution, as this medicine may trigger a manic episode.
Special Dietary and Lifestyle Recommendations
Practicing stress management techniques such as mindfulness, meditation, or yoga can be beneficial for managing depression and anxiety.
Frequently asked questions
Can Trazodone help with sleep?
Yes, Trazodone is sometimes prescribed to help manage insomnia, especially in patients who also have depression or anxiety.
Will Trazodone impact my fertility?
There's no evidence to suggest that Trazodone has any effect on fertility. However, if you're planning a pregnancy or are currently pregnant, you should consult your doctor before taking Trazodone.
Is it safe to take Trazodone every day?
Yes, it's generally safe to take Trazodone every day as long as your doctor has prescribed it. However, it's important to follow your doctor's instructions regarding dosing and duration of treatment.
How long does it take for Trazodone to work?
You may notice some improvement within 1-2 weeks of starting Trazodone, but it can take 6-8 weeks to feel the full antidepressant effects.
Do I need a prescription for Trazodone?
Yes, Trazodone is a prescription medication and is not typically available over the counter.
What is the best time to take Trazodone?
The best time to take Trazodone is usually at bedtime because it can cause drowsiness. Always follow your doctor's instructions on when and how to take this medication.
What is the duration of treatment with Trazodone?
The duration of treatment with Trazodone varies depending on the individual's response and the condition being managed. Always adhere to your doctor's prescribed treatment duration.
List of Medicines for Trazodone
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