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Trifluoperazine + Trihexyphenidyl

Uses of Trifluoperazine + Trihexyphenidyl

  • Trifluoperazine + Trihexyphenidyl is primarily used for the management of schizophrenia. It belongs to the group of antipsychotic and anticholinergic medications.

  • This combination medicine may also be used short-term for treating generalised anxiety disorder.

Side effects of Trifluoperazine + Trihexyphenidyl

  • Drowsiness, dizziness, lightheadedness

  • Dry mouth

  • Nausea, vomiting, stomach upset

  • Weight gain

  • Difficulty urinating

How Trifluoperazine + Trihexyphenidyl works

  • Trifluoperazine is an antipsychotic medicine. It works by reducing the activity of dopamine, a chemical messenger in the brain which is increased in schizophrenia.

  • Trihexyphenidyl is an anticholinergic medicine. It works on the nervous system and corrects some of the chemical imbalances that cause Parkinson's disease and certain side effects occurring during antipsychotic treatment.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Trifluoperazine + Trihexyphenidyl can be taken orally (tablet).

Age and Dose Restrictions

  • This combination medicine is meant for adults and children above the age of 18 years.

Contraindications

  • Trifluoperazine + Trihexyphenidyl is contraindicated in patients with known allergies to any of its components. It should not be taken by patients with narrow-angle glaucoma, peptic ulcer disease, bowel obstruction, severe liver or kidney disease, severe heart disease, bone marrow depression, coma, or CNS depression.

Other Medications to Avoid

  • This combination may interact with other central nervous system depressants (such as opioids, and benzodiazepines), and anticholinergic medications (like atropine, and scopolamine).

Overdose and Missed Dose

  • An overdose of Trifluoperazine + Trihexyphenidyl may result in symptoms such as drowsiness, confusion, or agitation. If you observe these symptoms after taking more than the prescribed dose, inform your doctor immediately.

  • If you forget to take a dose of this medicine, take it as soon as you remember. However, if it's almost time for your next dose, skip the forgotten dose and continue with your regular dosage schedule.

Management of Side Effects

Most side effects are temporary and generally harmless, and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For dry mouth, frequent sips of water or chewing sugar-free gum may help.

  • If dizziness occurs, it is advisable to sit or lie down until the feeling passes.

  • Constipation can often be relieved by drinking plenty of fluids and increasing dietary fibre.

Use in Driving and Operating Machinery

  • Trifluoperazine + Trihexyphenidyl may cause drowsiness or dizziness. If you experience these side effects, avoid driving or operating heavy machinery until you feel well enough.

Use in Pregnancy and Lactation

  • Consult your doctor before using this medicine if you are pregnant, planning a pregnancy or breastfeeding.

Caution in Other Conditions

  • Caution should be exercised when using Trifluoperazine + Trihexyphenidyl in patients with conditions such as glaucoma, urinary retention, and gastrointestinal obstruction.

Special Dietary and Lifestyle Recommendations

  • Staying hydrated by drinking plenty of fluids can help manage dry mouth associated with this medication.

Frequently asked questions

The duration of treatment with Trifluoperazine + Trihexyphenidyl varies depending on your condition and response to therapy. Your doctor will determine the appropriate duration of treatment for you.

Yes, weight gain is one of the common side effects associated with the use of Trifluoperazine + Trihexyphenidyl. If you notice any significant changes in your weight while taking this medicine, consult your doctor.

No, Trifluoperazine + Trihexyphenidyl is not classified as a controlled substance. However, it should not be used without a valid prescription from a doctor.

No, Trifluoperazine + Trihexyphenidyl is not a mood stabiliser. It is a combination medication used primarily to manage symptoms of schizophrenia and reduce extrapyramidal side effects caused by antipsychotic medicines.

Trifluoperazine + Trihexyphenidyl does not cause hormonal changes. However, any concerns should be discussed with your doctor.

Changes in the menstrual cycle are not a common side effect of Trifluoperazine + Trihexyphenidyl. However, if you notice any abnormal changes, consult your doctor immediately.

Yes, one of the common side effects of Trifluoperazine + Trihexyphenidyl is changes in appetite, which may lead to weight gain. If you notice any apppetite changes, consult your doctor immediately.

Terms & Conditions


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