Valacyclovir Hydrochloride
Uses of Valacyclovir Hydrochloride
Valacyclovir Hydrochloride is primarily used to manage infections caused by certain types of viruses and belongs to the class of antiviral medicines.
It is also used off-label to prevent cytomegalovirus (CMV) disease in kidney, heart, or pancreas transplant recipients at high risk.
Side effects of Valacyclovir Hydrochloride
Headache
Nausea
Abdominal Pain
Depression
Joint Pain
How Valacyclovir Hydrochloride works
Valacyclovir Hydrochloride is an antiviral medication.
It is inactive until it gets into the body. Once inside, it is rapidly converted into acyclovir and an amino acid called L-valine through first-pass intestinal and hepatic metabolism.
Acyclovir is a synthetic compound that is similar to a natural constituent of DNA. It works by interfering with the viral DNA synthesis, which essentially stops the replication of the viruses.
In cells infected with HSV or VZV, acyclovir is converted into acyclovir triphosphate, an active form of the medicine. This active form inhibits an enzyme called DNA polymerase, which is necessary for the virus to multiply. It also incorporates itself into the growing viral DNA chain, thereby preventing further viral replication.
Put simply, Valacyclovir Hydrochloride hinders the ability of viruses to grow and multiply in your body.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Valacyclovir Hydrochloride is available for oral administration in the form of tablets and powder to liquid suspensions.
Age and Dose Restrictions
Valacyclovir Hydrochloride is intended for use in adults and children who are at least 12 years of age.
Contraindications
Valacyclovir Hydrochloride is contraindicated in individuals with a known hypersensitivity to the active compound or any of its ingredients.
It should not be used by anyone who has a previous allergic reaction to acyclovir.
Other Medications to Avoid
Valacyclovir Hydrochloride can interact with medications that affect kidney function (such as cimetidine and ranitidine) and gout medication (like probenacid and allopurinol).
It may also interact with medicine used in organ transplantation (like mycophenolate mofetil), aminoglycoside antibiotics (e.g., neomycin, streptomycin), organoplatinum compounds (e.g., cisplatin, carboplatin), iodinated contrast media (used in imaging procedures), chemotherapy medicine (e.g., methotrexate, gemcitabine), medicines used to treat pneumonia (e.g., pentamidine, suramin) HIV medicatons (e.g., zidovudine, lamivudine).
Overdose and Missed Dose
An overdose of Valacyclovir Hydrochloride could lead to complications such as confusion, hallucinations, seizures, or renal problems. Immediate medical attention is recommended if an overdose is suspected.
If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped to avoid doubling up.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage nausea, taking the medicine with food might help.
Staying well-hydrated can help alleviate symptoms like headache and dizziness.
Use in Driving and Operating Machinery
Valacyclovir Hydrochloride may cause dizziness or other symptoms that could impair the ability to drive or operate machinery safely. It is advisable to avoid such activities if these symptoms are experienced.
Use in Pregnancy and Lactation
During pregnancy and lactation, Valacyclovir Hydrochloride should be used only when clearly needed and under direct medical supervision.
Caution in Other Conditions
Individuals with reduced kidney function may require adjusted doses of Valacyclovir Hydrochloride.
The medicine should be used with caution by elderly patients due to the increased risk of renal impairment.
Special Dietary and Lifestyle Recommendations
Maintaining adequate hydration is crucial while taking Valacyclovir Hydrochloride to support kidney health and aid in the prevention of potential side effects.
A nutritious, balanced diet can help strengthen the immune system, which is beneficial especially when managing viral infections like herpes.
Regular sleep patterns can also support overall health resilience, assisting in faster recovery during antiviral therapy.
Frequently asked questions
Is Valacyclovir Hydrochloride a type of steroid?
No, Valacyclovir Hydrochloride is not a steroid. It is an antiviral medicine used to manage infections caused by certain types of viruses.
Does taking Valacyclovir Hydrochloride affect sleep?
There is no substantial evidence to suggest that Valacyclovir Hydrochloride directly affects sleep. However, if you experience unusual sleep patterns after starting the medicine, consider consulting your doctor.
Can the use of Valacyclovir Hydrochloride impact fertility?
There is currently no significant evidence to suggest that the use of Valacyclovir Hydrochloride directly impacts fertility in men or women. If you have concerns regarding fertility, it is advisable to discuss them with your doctor.
Are there any dietary restrictions when taking Valacyclovir Hydrochloride?
There are no specific dietary restrictions when taking Valacyclovir Hydrochloride. However, it is critical to maintain adequate hydration during the treatment.
Is it safe to take Valacyclovir Hydrochloride daily?
The safety and efficacy of daily usage of Valacyclovir Hydrochloride depend on the specific medical condition and the overall health of the patient. Always follow your doctor's advice regarding the dosage and frequency of this medication.
How long does it take for Valacyclovir Hydrochloride to work?
Valacyclovir Hydrochloride starts working as soon as it is absorbed by the body. However, symptom relief may take a few days depending on the severity and type of infection.
What is the ideal time to take Valacyclovir Hydrochloride?
Valacyclovir Hydrochloride can be taken at any time as long as you follow your doctor's prescription. The medicine can be taken with or without food, and adequate hydration should be maintained during treatment.
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