Brevipil 50 Mg Tablet 10

Brevipil 50 Tablet 10

Sun Pharma Laboratories Ltd.

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Composition

Brivaracetam (50 Mg)

Strength:

75 MG 25 MG 50 MG 100 MG

Brevipil 50 Tablet is an anti-epileptic medication used to treat seizures in patients with epilepsy, especially when combined with other anti-seizure medications. It contains Brivaracetam, which stabilizes abnormal electrical activity in the brain, reducing the frequency and severity of seizures. Brevipil is effective in managing seizures that are not fully controlled by other medications, offering additional support for those with epilepsy.

As with any medication, it is crucial to consider potential side effects such as drowsiness, dizziness, nausea, and headache. However, it is worth noting that Brevipil generally exhibits good tolerability and can be well-managed with appropriate monitoring.

Close collaboration between patients, caregivers, and healthcare providers is crucial to ensure optimal dosing, monitor treatment response, and address any concerns or questions that may arise during therapy.

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Brevipil 50 Tablet is used as an adjunctive treatment of seizures in patients with epilepsy, aged four and older. It helps control seizures that occur in one part of the brain, lasting a few seconds to less than two minutes, without loss of consciousness.

Directions for Use of Brevipil 50 Tablet 10

Brevipil 50 mg tablets should be taken as your doctor recommends.
Swallow it as a whole with water after your meal to avoid stomach discomfort.
Do not cut, break or chew the medicine.
It would be best to take it at a fixed time for optimal results.
It would be best if you consumed what your doctor prescribes.

Brevipil 50 mg tablet is administered orally

Common side effects of Brevipil 50 mg tablets are:

Dizziness: Brevipil 50 mg tablet may cause dizziness, affecting balance and coordination. It is essential to be cautious when performing activities that need alertness, such as driving or operating machinery.
Fatigue: Some individuals may experience feelings of tiredness or fatigue while taking a Brevipil 50 mg tablet.
Nausea: Brevipil 50 mg tablet can occasionally cause nausea, resulting in an uneasy sensation in the stomach. Taking medicine with food may help minimise the side effects.
Vomiting: In some cases, Brevipil 50 mg tablets may lead to vomiting, which involves the forceful expulsion of stomach contents. If persistent or severe, medical advice should be sought.
Irritability: Brevipil 50 mg tablets may cause irritability, increasing frustration or agitation. If these symptoms become severe or disruptive, it is essential to consult a healthcare professional.
Abnormal Behavior: Rarely, Brevipil 50 mg tablet has been associated with changes in behaviour or mood, including aggression, hostility, and suicidal thoughts. It is crucial to promptly report any unusual or concerning behaviours to a healthcare provider.
Headache: Some individuals may experience headaches while taking a Brevipil 50 mg tablet. These headaches are generally mild to moderate in intensity.
Infection of nose and throat: This refers to inflammation of the nasal passages and throat, leading to symptoms such as a runny or stuffy nose, sore throat, or cough.
Decreased appetite: Some patients may experience decreased appetite while taking Brivaracetam. This can result in a reduced desire to eat and may lead to weight loss in some individuals.
Insomnia: Insomnia, or difficulty in sleeping, has been reported as a side effect of Brivaracetam. Patients may have trouble falling asleep or staying asleep throughout the night.
Vertigo: Vertigo, a sensation of spinning or dizziness, can occur as a side effect of Brivaracetam.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing Brevipil 50 mg tablets. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Brevipil 50 mg tablet treats partial-onset seizures in epilepsy. It binds to a protein called SV2A, which regulates neurotransmitter release in the brain. By modulating neurotransmission, particularly enhancing inhibitory signals mediated by GABA and potentially reducing excitatory signals, Brevipil helps to restore balance and suppress seizures. Its high affinity for SV2A and favourable pharmacokinetics contribute to its effectiveness. Overall, Brevipil 50 mg tablet is a valuable medication for managing partial-onset seizures.

Pregnancy

Is it safe to use the Brevipil 50 Tablet during pregnancy?

Only limited data regarding using Brevipil 50 mg tablets in pregnant women is available. As a precaution, brivaracetam should not be used during pregnancy unless clinically necessary. If you are pregnant or considering pregnancy, it is crucial to have a detailed discussion with your healthcare provider regarding the potential risks and benefits of using the Brevipil 50 mg tablet.

Breastfeeding

Is it safe to consume Brevipil 50 Tablet during breastfeeding?

There is limited information on the safety of Brevipil 50 mg tablets during breastfeeding. It may be excreted into breast milk. When considering the Brevipil 50 mg tablet for the mother, it is advisable to consult with a healthcare provider who will make the decision and thoroughly assess its importance.

Alcohol

Is it safe to drink alcohol while taking Brevipil 50 Tablet?

Consumption of alcohol should be stopped while taking a Brevipil 50 mg tablet. Combining alcohol with a Brevipil 50 mg tablet can increase drowsiness, dizziness, and coordination difficulties.

Liver

Is it advisable to take Brevipil 50 Tablet when experiencing liver problems?

Patients with severe liver impairment should be closely monitored while taking Brevipil 50 mg tablets.

Kidney

Is it advisable to consume Brevipil 50 Tablet when experiencing kidney problems?

Brevipil 50 mg tablets should be used cautiously in patients with kidney problems. Dosage adjustments may be required in individuals with significant kidney dysfunction.

Using Machines & Driving

Is it safe to operate heavy machinery or drive when using the Brevipil 50 Tablet?

It is essential to assess individual responses to Brevipil 50 mg tablets and avoid driving or operating machinery if these side effects are experienced. Patients should be cautious when performing tasks requiring mental alertness until they are familiar with their response to the medication.

Allergy

Are there any specific conditions that should be considered before taking the Brevipil 50 Tablet?

Brevipil 50 mg tablets should not be used in individuals with known hypersensitivity to Brivaracetam or any other of its components.

Children

Is Brevipil 50 Tablet suitable for infants or children?

The safety and effectiveness of Brevipil 50 mg tablets in children below the age of 4 years have not been established. Dosage adjustments may be necessary based on age and weight. Brevipil 50 mg tablets may be used in children under the supervision of a healthcare provider.

Older Patients

Is Brevipil 50 Tablet suitable for older patients?

Elderly patients aged 65 years and above may be more sensitive to the effects of Brivaracetam. Dose adjustments may be required based on individual response and kidney function.

Drug-Drug Interactions

Brevipil 50 mg tablet can interact with medications, including

Carbamazepine and Phenytoin: Carbamazepine and phenytoin are enzyme-inducing antiepileptic drugs (AEDs) that may increase the metabolism of Brevipil 50 mg tablets, leading to reduced blood levels and potential loss of efficacy.
Rifampicin: Rifampicin, an antibiotic used to treat tuberculosis, is a potent enzyme inducer that may increase the metabolism of Brevipil 50 mg tablet, leading to reduced blood levels and potential loss of efficacy.
Buprenorphine and Propoxyphene: Buprenorphine and propoxyphene are opioids that may enhance the sedative effects of Brevipil 50 mg tablets, leading to increased drowsiness and respiratory depression.
Ketamine: Ketamine are anaesthetics that may enhance the CNS depressant effects of Brevipil 50 mg tablet, leading to increased sedation and impaired cognitive function.
Sodium Oxybate: Sodium oxybate, a central nervous system depressant that treats narcolepsy, may enhance the sedative effects of Brevipil 50 mg tablet, leading to increased drowsiness and impaired cognitive function.

Drug-Food Interactions

Brevipil 50 mg tablet can interact with foods including

Alcohol: Both Brevipil 50 mg tablets and alcohol can cause central nervous system (CNS) depression, which may lead to increased sedation and impairment of cognitive function.

Drug-Disease Interactions

Brevipil 50 mg tablet can interact with diseases, including-

Allergy: Individuals with hypersensitivity or allergy to Brivaracetam or any of its components should not use the Brevipil 50 mg tablet.
Notifying your doctor about any known allergies before starting a Brevipil 50 mg tablet is essential. If you suffer from any symptoms of an allergic reaction, like rash, itching, swelling, or difficulty breathing, seek immediate medical attention.
Liver Impairment: Brevipil 50 mg tablet is primarily metabolised in the liver. Patients with liver impairment may experience reduced medication clearance, leading to higher blood levels and an increased risk of adverse effects.
Kidney Impairment: Brevipil 50 mg tablet is eliminated from the body primarily through the kidneys. Patients with kidney impairment may have reduced elimination of the medication, resulting in higher blood levels and an increased risk of adverse effects.
Suicidal Tendency: There have been reports of an increased likelihood of suicidal thoughts in patients using antiepileptic drugs, including Brevipil 50 mg tablet.

Daily Dose

The recommended dose of Brevipil 50 mg tablet is once daily, with food, as directed by your doctor. The dosage may change based on individual factors such as the severity of the condition and response to treatment. It is essential to follow the suggested dosage and not exceed it without consulting your doctor.

Over Dose

If you or someone else takes an excessive amount of Brevipil 50 mg tablet by accident, it is essential to take immediate medical attention from your doctor or nearby hospital. Symptoms of an overdose may include dizziness, drowsiness, nausea, vertigo, difficulties with balance, anxiety, fatigue, irritability, and aggression.

Missed Dose

If you forgot to take the Brevipil 50 mg tablet, take it as soon as you recall or as your health care provider instructed. If the time for the next dosage is close, skipping the missed one is recommended now and resume your regular dosage pattern. Never increase your dosage without consulting your doctor.

Store Brevipil 50 mg tablet at room temperature (15-25ºC).
Please protect it from light and moisture.
Keep Brevipil 50 mg tablets away from children.
Do not use the Brevipil 50 mg tablet after the expiry date has passed.

Diet: Consider adopting a ketogenic diet low in carbohydrates and fats for children with epilepsy. This diet encourages the utilisation of fat instead of glucose for energy production. Adolescents and adults may benefit from an Atkins diet, which is high in fat and controls carbohydrates.
Regular Exercise: Regular physical activity helps maintain a healthy weight and improves overall well-being.
Sufficient Rest: Ensure you get adequate sleep to support your overall health.
Avoid Smoking and Alcohol: It is crucial to refrain from smoking and alcohol consumption while taking a Brevipil 50 mg tablet.
Stress Reduction: Incorporate stress management techniques such as meditation and yoga to lower stress levels, decrease pain sensitivity, and improve coping skills.
Seizure Response Plan: Develop a plan that outlines the steps to take during a seizure, and inform those around you about it.
Safe Living Environment: Make necessary adjustments to your living area to minimise the risk of physical injury during a seizure.
Identify Triggers: Understand the factors that can trigger seizures and try to reduce or avoid them.
Overall Health: Pay attention to your general health, as it can contribute to a reduction in seizure activity.
Emergency Assistance: Install an alarm or emergency device to assist in a seizure episode.

Adhere to the same brand of your medicine and always have enough of it with you.
Pay attention to any sudden changes in your mood, behaviour, thoughts, or feelings, and let your doctor know immediately if anything unusual happens.
Take your follow-up appointments with your doctor.
Do not stop taking a Brevipil 50 Tablet without talking to your doctor, even if you feel improvement in your condition.
Follow your prescribed dosage schedule and take the medication at the specified times.

Fact Box

Drug Category	Levetiracetam Derivative
Therapeutic Category	Antiepileptics
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Epilepsy

How do I stop the Brevipil 50 mg tablet?

Always consult your doctor before stopping Brevipil 50 mg tablets or any medication. Abruptly discontinuing Brevipil 50 mg tablets can have adverse effects and increase the risk of complications. If needed, your doctor will guide you to taper off the medication, gradually reducing the dosage. Follow your doctor's instructions and change your medication with their guidance.

Can I drink alcohol with a Brevipil 50 mg tablet?

It is generally recommended to avoid or limit alcohol consumption while taking a Brevipil 50 mg tablet or any other medication. Alcohol can interact with Brevipil 50 mg tablets and may raise the risk of side effects such as drowsiness, dizziness, and impaired coordination.

Does Brevipil 50 mg tablet cause sleepiness?

Brevipil 50 mg tablets can cause drowsiness as a side effect, so it is vital to be careful in activities requiring alertness. If excessive drowsiness occurs, consult your doctor for possible dosage adjustments or strategies to manage it effectively.

Is Brevipil 50 mg tablet considered safe?

Brevipil 50 mg tablets are safe when used as the doctor directs but can have potential side effects and interactions. Follow your doctor's instructions, discuss concerns, and promptly report adverse reactions. Your doctor will assess the risks and benefits to determine if Brevipil 50 mg tablet suits you.

How effective is Brevipil 50 mg tablet?

Brevipil 50 mg tablet effectively manages and reduces seizures in patients with epilepsy. However, individual responses may vary, so close monitoring and collaboration with your healthcare provider are essential for optimising treatment effectiveness.

Can Brevipil 50 mg tablet be taken once a day?

Brevipil 50 mg tablet's dosing regimen is individualised and may differ among patients. It can be prescribed once daily or multiple times daily, depending on the patient's specific needs. It is crucial to adhere to the instructions given by your healthcare provider regarding the timing and frequency of the Brevipil 50 mg tablet to achieve the best outcomes and ensure safety. Consult your healthcare provider if you have any concerns or questions about the dosing schedule.

What is the duration of action of the Brevipil 50 mg tablet?

The duration of action of Brevipil 50 mg tablets varies among individuals and depends on factors like metabolism and individual response. To ensure continuous seizure control and maintain therapeutic levels, it is typically necessary to follow the recommended dosage of the doctor. Follow your doctor's prescribed dosing schedule for optimal effectiveness, and consult your healthcare provider for any questions or concerns.

Does Brevipil 50 mg tablet cause weight loss?

Weight loss is not a commonly reported side effect of Brevipil 50 mg tablets, but individual responses may vary. If you experience significant weight loss or any other concerning symptoms while taking a Brevipil 50 mg tablet, it is essential to consult your healthcare provider for evaluation and guidance.

Does Brevipil 50 mg tablet affect the liver?

Rare instances of liver injury have been reported with Brevipil 50 mg tablets, warranting liver function monitoring, especially in patients with pre-existing liver conditions or using liver-affecting medications. Seek immediate medical attention if symptoms of liver problems arise and discuss any concerns with your healthcare provider.

What should I avoid while taking the Brevipil 50 mg tablet?

Until you understand how a Brevipil 50 mg tablet affects you, you must refrain from engaging in activities that demand mental alertness and coordination, such as driving or operating machinery. Additionally, it is recommended to avoid consuming alcohol as it may increase the risk of side effects. Talk to your healthcare provider about specific precautions or restrictions based on your situation.

Last Updated On 22 Nov. 2024 | 5:09AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

Patient Information. (n.d.). Retrieved February 12, 2024, from https://www.briviact.com/briviact-patient-brochure.pdf
PIL. (n.d.). Retrieved February 12, 2024, from https://s3.pgkb.org/attachment/brivaracetam_HCSC_Aug2016.pdf
Patient Information. (n.d.). Retrieved February 12, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/205836s005,205837s004,205838s003lbl.pdf

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