Grafmet 500mg Injection 1

Grafmet 500mg Injection 1 is used for the following:

• Primary or secondary adrenocortical insufficiency

• Severe allergic conditions such as bronchial asthma and contact dermatitis.

• Congenital adrenal hyperplasia

• Non-suppurative thyroiditis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Systemic lupus erythematosus

• Systemic dermatomyositis

• Pemphigus

• Severe erythema multiforme

• Sympathetic ophthalmia

• Uveitis

• Ulcerative colitis

• Crohn's disease

• Aspiration pneumonitis

• Disseminated pulmonary tuberculosis

• Idiopathic thrombocytopenic purpura

• Secondary thrombocytopenia.

• Palliative management of leukemias and lymphomas

Administer Grafmet 500mg Injection 1 as follows:

• This medicine should be administered by a doctor, usually into a muscle or vein.

• The injection site should be clean and dry before administration.

• Remember to consult your doctor about the frequency of administration based on your medical condition.

• Do not self-administer this medicine at home unless properly trained.

Grafmet 500mg Injection 1 is administered intravenously or via an intramuscular route.

Grafmet 500mg Injection 1 contains Methylprednisolone (500 mg). Here is how it works on your body:

• Rapid hydrolysis: Once administered, methylprednisolone sodium succinate is rapidly processed in the liver into its active form methylprednisolone.

• Inhibition of proinflammatory mediators: Methylprednisolone inhibits substances such as prostaglandins and leukotrienes that contribute to inflammation.

• Suppression of cellmediated immunity: The medicine prompts lymphocytes (a type of white blood cell) to self-destruct (apoptosis), which helps suppress the immune response.

• Alteration of cytokine production: Methylprednisolone alters the production of cytokines – these are proteins that regulate immunity and inflammation.

• Mineralocorticoid activity: At certain doses, methylprednisolone affects the balance of water and electrolytes in your body.

• Keep Grafmet 500mg Injection 1 stored at a consistent temperature of 20 °C to 25 °C.

• The product should be protected from light.

• Ensure it's kept out of reach and sight of children.

• Always make sure to use it before the expiry date on the package.

• If you are managing conditions like rheumatoid arthritis or systemic lupus erythematosus, try to eat a balanced diet rich in fruits, vegetables, lean proteins, and whole grains. This can help your body recover and manage inflammation better.

• If you're using Grafmet 500mg Injection 1 for asthma or other respiratory conditions, quitting smoking or avoiding secondhand smoke can significantly improve your lung function and overall health.