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Aceclofenac + Diacerein

Uses of Aceclofenac + Diacerein

  • Aceclofenac + Diacerein is primarily used to relieve pain and inflammation (swelling) in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. 
  • This combination belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) and anti-rheumatic medicines, which help reduce pain and swelling caused by these conditions.

Side effects of Aceclofenac + Diacerein

  • Abdominal pain

  • Diarrhoea

  • Nausea

  • Vomiting

  • Flatulence

How Aceclofenac + Diacerein works

  • Aceclofenac, an integral part of this combination, is classified as a non-steroidal anti-inflammatory drug (NSAID). It acts by blocking the working of cyclooxygenase (COX) enzymes, which produce prostaglandins that cause pain, inflammation, and fever. By restraining prostaglandin production, Aceclofenac reduces pain and inflammation.

  • Diacerein, the second component, is an anti-rheumatic medication. It functions by inhibiting a pro-inflammatory substance called interleukin-1 beta (IL-1β), which contributes to cartilage breakdown and development of painful symptoms in osteoarthritis (OA). By reducing the sensitivity of chondrocytes (cartilage cells) to IL-1β and decreasing its production, Diacerein slows down the degradation of cartilage.

  • Combined, Aceclofenac and Diacerein work together to suppress inflammation, alleviate pain, improve joint function, and provide chondroprotective effects that can slow disease progression.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Aceclofenac + Diacerein is available for oral use in the form of tablets.

Age and Dose Restrictions

  • This medicine is typically prescribed for adults.

Contraindications

  • It is contraindicated in patients who have hypersensitivity towards aceclofenac, diacerein, or any other excipients in the medicine.

  • Patients with active peptic ulcers, recent history of gastrointestinal bleeding or perforation, severe liver or kidney failure, or severe heart failure are advised not to take Aceclofenac + Diacerein.

Other Medications to Avoid

  • Aceclofenac + Diacerein may interact with other nonsteroidal anti-inflammatory drugs (e.g., aspirin and ibuprofen), anticoagulants (e.g., dabigatran and warfarin), antiplatelet drugs (e.g., ticagrelor and clopidogrel), corticosteroids (e.g., cortisone and prednisone), selective serotonin reuptake inhibitors (e.g., citalopram and fluoxetine), diuretics (e.g., torsemide and furosemide), ACE inhibitors and angiotensin receptor blockers (e.g., lisinopril and benazepril), mood stabilizers (lithium), cancer medications (methotrexate), and immunosuppressants (cyclosporine).

Overdose and Missed Dose

  • Overdosing on Aceclofenac + Diacerein can cause serious health problems, such as severe gastrointestinal issues or liver damage. If you suspect an overdose, seek immediate medical help.

  • In case of a missed dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed one. Do not double the dose to make up for a missed one.

Management of Side Effects

Most side effects of Aceclofenac + Diacerein are temporary and resolve once you discontinue the medicine. If any side effects persist, consult your doctor.

  • To manage gastrointestinal disturbances, taking the medicine with meals and staying properly hydrated can help.

Use in Driving and Operating Machinery

  • Aceclofenac + Diacerein may cause dizziness or sleepiness in some patients. If you experience these effects, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • It is advisable to consult your doctor before using Aceclofenac + Diacerein if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with a history of peptic ulcer or gastrointestinal bleeding, kidney or liver impairment, blood disorders, or cardiovascular disease should exercise caution while taking Aceclofenac + Diacerein.

  • Elderly patients should also be cautious as they might be more sensitive to the side effects of this combination.

Special Dietary and Lifestyle Recommendations

  • Regular physical activity can help manage symptoms of conditions like osteoarthritis and rheumatoid arthritis.

  • Maintain a balanced diet that includes plenty of fruits, vegetables, and whole grains to ensure overall health.

  • Limit the consumption of alcohol, as it can interact with the medication and lead to adverse effects.

  • Smoking can exacerbate conditions like osteoarthritis and rheumatoid arthritis. It is advised to quit smoking for better health outcomes.

Frequently asked questions

No, Aceclofenac + Diacerein is not a steroid. It is a combination of two active ingredients, aceclofenac and diacerein, which are non-steroidal anti-inflammatory drugs and anti-rheumatic medicines, respectively.

There are no common side effects reported with Aceclofenac + Diacerein that would interfere with sleep. However, individual responses may vary, and if you notice any changes in your sleep patterns while taking this medication, it is advised to consult your doctor.

The use of Aceclofenac + Diacerein should be as per your doctor's recommendation, typically for a duration of 2-3 months. Long-term continuous use isn't recommended due to the risk of side effects.

Pain relief usually starts within a few hours after taking the first dose of Aceclofenac + Diacerein, while the maximum benefits are seen in 2-4 weeks.

The recommended dosage of Aceclofenac + Diacerein should be taken as directed by doctor. It is always best to adhere to your doctor's advice regarding the timing and dosage of your medication.

There is no scientific evidence to suggest that Aceclofenac + Diacerein directly affect mood. However, as it helps manage pain and inflammation, it could indirectly improve mood by reducing discomfort.

There is no scientific evidence to suggest that Aceclofenac + Diacerein directly affects menstruation.

Terms & Conditions


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