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Alendronate / Alendronic Acid

Uses of Alendronate / Alendronic Acid

  • Alendronate / Alendronic Acid is primarily used to manage osteoporosis in both postmenopausal women and men, and it belongs to the bisphosphonate class of medicines.
  • In addition, it is also used for managing Paget's disease of the bone, a disorder characterised by excessive and abnormal bone remodelling.

Side effects of Alendronate / Alendronic Acid

  • Abdominal pain
  • Acid regurgitation
  • Constipation
  • Diarrhoea
  • Musculoskeletal pain

How Alendronate / Alendronic Acid works

  • Alendronate, or Alendronic Acid, is a bisphosphonate.
  • It operates by limiting bone resorption, which is the process wherein osteoclasts, a type of cell, break down bone tissue. By doing so, Alendronate/Alendronic Acid hinders osteoclast activity, which enhances bone mineral density (BMD) and fortifies bones, making them less prone to fractures.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Alendronate/Alendronic Acid is available to be taken orally (tablets, effervescent tablets, and a solution).

Age and Dose Restrictions

  • This medicine is primarily intended for adults.

Contraindications

  • Alendronate / Alendronic Acid is contraindicated in individuals with known hypersensitivity to any components of the formulation.
  • It should not be taken by those with certain oesophageal abnormalities such as strictures or achalasia.
  • Patients who are unable to remain upright (sitting or standing) for at least 30 minutes should also avoid this medicine.
  • It is contraindicated in individuals diagnosed with hypocalcaemia.

Other Medications to Avoid

  • This medicine can interact with products containing calcium, magnesium, aluminium, or other minerals such as calcium supplements and antacids and non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., naproxen, ibuprofen, aspirin).

Overdose and Missed Dose

  • An overdose of Alendronate/Alendronic Acid may result in conditions like hypocalcaemia, hypophosphatemia, and upper gastrointestinal adverse events. If an overdose is suspected, immediate medical attention should be sought.
  • If a dose is missed, it should be taken as soon as it is remembered. However, if it's nearly time for the next dose, the missed dose should be skipped. Double dosing should be avoided.

Management of Side Effects

  • Most side effects are temporary, generally harmless, and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
  • Drinking plenty of water may help manage side effects like constipation and dry mouth.
  • Mild exercise, such as walking, may assist in managing musculoskeletal pain.

Use in Driving and Operating Machinery

  • Alendronate/Alendronic Acid does not typically affect one's ability to drive or operate machinery. However, some people may experience dizziness as a side effect. If this occurs, avoid driving or operating machinery until the dizziness subsides.

Use in Pregnancy and Lactation

  • The safety of Alendronate/Alendronic Acid during pregnancy and lactation has not been established. It is advisable to consult a doctor before using this medicine during these periods.

Caution in Other Conditions

  • Individuals with kidney disease and low calcium levels may need to use Alendronate/Alendronic Acid with caution.

Special Dietary and Lifestyle Recommendations

  • Engage in weight-bearing exercises like walking, jogging or lifting weights to help strengthen your bones.
  • Ensure adequate intake of calcium and vitamin D through diet or supplements, as both are crucial for bone health.
  • Avoid smoking and limit alcohol consumption as both can cause bone loss.
  • Maintain a healthy weight to reduce strain on your bones and joints.

Frequently asked questions

No, Alendronate/Alendronic Acid does not contain calcium. It is a bisphosphonate used to manage osteoporosis and Paget's disease of the bone.

There is no specific mention in the research data about Alendronate/Alendronic Acid significantly affecting appetite. However, if you notice any unusual changes in your appetite while taking this medicine, it would be wise to consult your doctor.

You should ideally wait at least 30 minutes after taking Alendronate/Alendronic Acid before consuming any other medicines, including vitamins and supplements. This is because some minerals can interfere with the absorption of Alendronate/Alendronic Acid.

Alendronate / Alendronic Acid does not cause physical dependence, so there should not be withdrawal symptoms when discontinuing the medicine. However, always consult your doctor before stopping any medication.

It is generally advised that you limit your alcohol intake while on any medication, as alcohol can interfere with the effectiveness of medicines and may increase the risk of side effects.

Antacids containing minerals like calcium, magnesium, or aluminium can interfere with the absorption of Alendronate/Alendronic Acid. Thus, it is advised to wait at least 30 minutes after taking this medicine before consuming antacids.

There is no specific mention of mood changes as a side effect of Alendronate/Alendronic Acid in the research dossier. However, everyone reacts differently to medicines, and if you notice any significant mood changes while taking this medication, consult your doctor.

Terms & Conditions


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