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Alprazolam + Sertraline

Uses of Alprazolam + Sertraline

  • Alprazolam + Sertraline is primarily used for the management of major depressive disorder in patients who also experience significant symptoms of anxiety. It belongs to the benzodiazepine and selective serotonin reuptake inhibitor (SSRI) group of medicines.

  • This combination can also be beneficial for managing conditions such as panic disorder, generalized anxiety disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and premenstrual dysphoric disorder (PMDD).

Side effects of Alprazolam + Sertraline

  • Drowsiness

  • Dizziness

  • Headache

How Alprazolam + Sertraline works

  • Alprazolam is a member of the benzodiazepine family. It works by binding to specific sites on GABA-A receptors in the brain, which helps to reduce the excessive neuronal activity that causes anxiety.

  • Sertraline is categorised as a Selective Serotonin Reuptake Inhibitor (SSRI). It works by blocking the reuptake of serotonin, a neurotransmitter, in the brain. This increase in serotonin levels in synapses leads to an improved mood and a reduction in depressive symptoms.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Divya Chauhan
Dr. Divya Chauhan Medical Writer & Reviewer| 6 years

BAMS, APG, PG

Expert Advice

Dosage Forms Available

  • Alprazolam + Sertraline is available for oral administration (tablet).

Age and Dose Restrictions

  • This medicine is meant for adults and children above 12 years of age.

Contraindications

  • Alprazolam + Sertraline is contraindicated in patients with a known allergy to alprazolam, sertraline, or any component of this medication.

  • It is also contraindicated in patients with acute narrow-angle glaucoma and those currently using monoamine oxidase inhibitors (MAOIs).

Other Medications to Avoid

  • This combination can interact with CNS depressants (e.g., opioids, barbiturates) and CYP3A4 inhibitors (e.g., azole antifungals and protease inhibitors), CYP2D6 substrates (e.g., tricyclic antidepressants, antipsychotics) due to its inhibitory effects on CYP2D6.

Overdose and Missed Dose

  • An overdose of Alprazolam + Sertraline can cause serious side effects such as extreme drowsiness, confusion, impaired coordination, diminished reflexes, coma, or death. In case of suspected overdose, seek immediate medical attention.

  • If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double your dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If you experience drowsiness or dizziness after taking this medication, try to take your dose before going to bed.

  • To manage gastrointestinal disturbances like nausea, diarrhoea, and constipation, ensure you maintain adequate hydration by drinking plenty of water.

Use in Driving and Operating Machinery

  • Alprazolam + Sertraline may affect your ability to drive or operate heavy machinery. If you feel dizzy or sleepy after taking this medication, avoid such activities until you know how this medication affects you.

Use in Pregnancy and Lactation

  • Pregnant and breastfeeding women should consult their doctor before using Alprazolam + Sertraline as it may pose potential risks to the fetus or infant.

Caution in Other Conditions

  • Patients with a history of seizures, hepatic or renal impairment, mania or hypomania, bleeding disorders or those using medicines that increase bleeding risk should exercise caution when using Alprazolam + Sertraline.

Special Dietary and Lifestyle Recommendations

  • Managing stress through relaxation exercises like yoga or meditation can be beneficial in managing anxiety disorders and depression.

  • Ensure you have a regular sleep pattern to avoid triggering anxiety or depressive symptoms.

Frequently asked questions

Alprazolam + Sertraline combination is not known to affect fertility. However, if you have concerns about fertility, it is advisable to consult your doctor.

While there are some natural remedies suggested for managing symptoms of depression and anxiety, such as St John's Wort or chamomile, they should never be used as a substitute for prescribed medication without consulting a doctor. These natural alternatives may not be as effective or may interact with other medicines.

Alprazolam + Sertraline is not associated with affecting the menstrual cycle. However, each individual may react differently to the medicine, and it is advisable to consult your doctor if you have any concerns.

It is generally safe to take vitamins with Alprazolam + Sertraline, but it is always best to consult your doctor before starting any new medication or supplement.

While changes in appetite or weight can be a side effect of Alprazolam + Sertraline, it is not specifically used to manage appetite loss. Always consult your doctor for appropriate treatments for appetite loss.

The effects of Alprazolam + Sertraline can vary depending on the individual and the condition being managed. Some people might notice improvements within a few weeks, while for others it might take longer. Always follow your doctor's instructions regarding the duration of treatment.

No, Alprazolam + Sertraline is not a steroid. It is a combination medication that includes Alprazolam, a benzodiazepine and Sertraline, a selective serotonin reuptake inhibitor (SSRI) antidepressant.

Terms & Conditions


Available medicines for ALPRAZOLAM + SERTRALINE
Alprax Forte 0.5/50 MG Tablet 10
Alprax Forte 0.5/50 MG Tablet 10
Torrent Pharmaceuticals Ltd.
Pack of 10 Units
₹67.57
MRP ₹82.40
18.00% OFF
Trika Plus 0.5/25 MG Tablet 10
Trika Plus 0.5/25 MG Tablet 10
Torrent Pharmaceuticals Ltd.
Pack of 10 Units
₹51.82
MRP ₹63.20
18.00% OFF
Alarm Forte 0.5/50 MG Tablet 10
Alarm Forte 0.5/50 MG Tablet 10
Organic Laboratories
Pack of 10 Units
₹59.78
MRP ₹72.90
18.00% OFF
Alprax Plus 0.5/25 MG Tablet 10
Alprax Plus 0.5/25 MG Tablet 10
Torrent Pharmaceuticals Ltd.
Pack of 10 Units
₹47.48
MRP ₹57.90
18.00% OFF
Alarm Plus 0.5/25 MG Tablet 10
Alarm Plus 0.5/25 MG Tablet 10
Organic Laboratories
Pack of 10 Units
₹46.74
MRP ₹57.00
18.00% OFF
Alzex Forte 0.5/50 MG Tablet 10
Alzex Forte 0.5/50 MG Tablet 10
Psychotropics India Ltd
Pack of 10 Units
₹33.19
MRP ₹40.47
18.00% OFF
Alzolam Forte 0.5/50 MG Tablet 10
Alzolam Forte 0.5/50 MG Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹38.54
MRP ₹47.00
18.00% OFF
Alzex Plus 0.25/25 MG Tablet 10
Alzex Plus 0.25/25 MG Tablet 10
Psychotropics India Ltd
Pack of 10 Units
₹28.70
MRP ₹35.00
18.00% OFF

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