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Amitriptyline + Pregabalin

Uses of Amitriptyline + Pregabalin

  • Amitriptyline + Pregabalin is used in managing various types of chronic pain conditions, particularly neuropathic pain. This combination belongs to the group of antidepressant and anticonvulsant medicines.

  • Additionally, it may be used as an adjunctive treatment for controlling certain types of seizures.

Side effects of Amitriptyline + Pregabalin

  • Drowsiness

  • Dizziness

  • Dry mouth

  • Weight gain

  • Blurred vision

How Amitriptyline + Pregabalin works

  • Amitriptyline + Pregabalin is a combination medicine consisting of an antidepressant and an anticonvulsant.

  • Amitriptyline belongs to the group of medicines known as tricyclic antidepressants. It works by increasing the levels of chemical messengers, serotonin and norepinephrine, in the brain. These messengers help to regulate mood and reduce the sensation of pain.

  • Pregabalin is an anticonvulsant. It decreases the release of several neurotransmitters by binding to calcium channels in the central nervous system. Neurotransmitters are chemicals that nerves use to communicate with each other. By reducing their release, Pregabalin minimises abnormal electrical activity in the brain, thus helping to manage neuropathic pain.

  • When used together, these two components work synergistically to manage chronic pain conditions effectively, especially those related to nerve damage or neuropathic pain.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Dr. Michelle Frank
Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Expert Advice

Dosage Forms Available

  • Amitriptyline + Pregabalin is available as oral tablets and capsules. These are meant to be taken by mouth with water, as directed by the doctor.

  • It is important to follow the instructions provided by the doctor for proper administration of this medication.

Age and Dose Restrictions

  • This medicine is meant for adults and adolescents who are older than 16 years of age.

Contraindications

  • Amitriptyline + Pregabalin is contraindicated in patients with known hypersensitivity to either of the active ingredients.

  • It is also not recommended for individuals who have recently suffered a heart attack.

Other Medications to Avoid

  • Amitriptyline + Pregabalin may interact with other antidepressants (such as fluoxetine and selegiline), anticonvulsants (like gabapentin and levetiracetam), and sedatives (including diazepam or lorazepam).

Overdose and Missed Dose

  • If you accidentally take more than your prescribed dose of Amitriptyline + Pregabalin, you may experience symptoms such as severe drowsiness or confusion. In such cases, contact your doctor immediately or seek urgent medical attention.

  • If you miss a dose of this medication, take it as soon as you remember. If it is already time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not double up your dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and usually subside without intervention when this medication is discontinued. However, if you experience any severe side effects, please consult your doctor.

  • Drinking plenty of water can help manage some of the common side effects, like dry mouth and constipation.

  • If you experience confusion, taking your medication in the evening or before bedtime may be beneficial.

Use in Driving and Operating Machinery

  • Amitriptyline + Pregabalin may cause drowsiness or dizziness. These side effects may affect your ability to drive or operate heavy machinery. It is advisable to avoid such activities until you know how this combination affects you.

Use in Pregnancy and Lactation

  • Amitriptyline + Pregabalin should be used during pregnancy or breastfeeding only if the potential benefits outweigh the risks. Always consult your doctor before using this medication if you are pregnant or nursing.

Caution in Other Conditions

  • Caution should be exercised when using Amitriptyline + Pregabalin in individuals with liver or kidney problems, diabetes, and certain psychiatric conditions.

  • Individuals with a history of seizures or angle-closure glaucoma should also use this combination with caution.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet to help manage weight gain, a possible side effect of this medication.

  • Regular but moderate physical activity can also aid in managing weight and improving overall well-being.

  • For those experiencing constipation, a diet high in fibre combined with regular exercise can be beneficial.

Frequently asked questions

No, Amitriptyline + Pregabalin is not a steroid. It is a combination of two different types of medication: Amitriptyline, which is a tricyclic antidepressant, and Pregabalin, which is an anticonvulsant and pain-relieving medicine.

Yes, one of the common side effects of Amitriptyline + Pregabalin can be could potentially affect your sleep patterns. If you are experiencing sleep disturbances after taking this medicine, it is advisable to consult your doctor.

Amitriptyline + Pregabalin is not directly associated with affecting fertility. However, if you are planning to conceive or if you have fertility concerns, kindly discuss this with your doctor.

Yes, it is safe to take Amitriptyline + Pregabalin daily if it has been prescribed by your doctor for your condition.

The time it takes for Amitriptyline + Pregabalin to show its effects can vary depending on the individual and the condition being managed. This is something you should discuss with your doctor.

The best time to take Amitriptyline + Pregabalin would be as directed by your doctor. This can depend on various factors including your daily schedule, the specific condition being managed, and your overall health.

Yes, weight gain can occur as a side effect of Amitriptyline + Pregabalin. This can be due to increased appetite or fluid retention caused by the medication.

Terms & Conditions


Available medicines for AMITRIPTYLINE + PREGABALIN
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Neugatrip 75/10 MG Tablet 10
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Gabrica At Capsule 10
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