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Amlodipine + Perindopril

Uses of Amlodipine + Perindopril

  • The primary use of Amlodipine + Perindopril is for the management of primary hypertension. This combination belongs to antihypertensive medications.

  • It is also used for preventing heart attacks and reducing the risk of cardiovascular mortality in patients with stable coronary artery disease. Furthermore, it is effective in managing chronic stable angina and vasospastic (Prinzmetal's) angina.

Side effects of Amlodipine + Perindopril

  • Swelling, mainly in the ankles and feet

  • Headache

  • Dizziness

  • Nausea

  • Fatigue

How Amlodipine + Perindopril works

  • Amlodipine belongs to the calcium channel blocker class of medicines. It works by stopping the entry of calcium into blood vessel walls and heart cells. This relaxes and widens the blood vessels, allowing blood to flow more easily, thereby lowering blood pressure.

  • Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking an enzyme in the body that leads to a substance which narrows blood vessels. With less of this substance, blood vessels can widen, and the blood pressure decreases. Working together, these medicines help lower high blood pressure and reduce the risk of heart-related problems.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Dr. Michelle Frank
Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Expert Advice

Dosage Forms Available

  • Amlodipine + Perindopril is available in tablet form for oral administration.

Age and Dose Restrictions

  • Amlodipine + Perindopril is generally recommended for adults and children above 18 years of age.

Contraindications

  • This medicine is contraindicated in patients with known hypersensitivity to perindopril, amlodipine, or any of the excipients.

  • It is also contraindicated for patients with a history of angioedema related to previous ACE inhibitor therapy and patients with hereditary or idiopathic angioedema.

Other Medications to Avoid

  • Amlodipine + Perindopril may interact with potassium supplements and potassium-sparing diuretics (eg., potassium chloride and spironolactone), non-steroidal anti-inflammatory medicines (eg., ibuprofen), and antidiabetic agents (eg., metformin).

Overdose and Missed Dose

  • An overdose of Amlodipine + Perindopril may cause excessive peripheral vasodilation, marked and probably prolonged hypotension, shock, stupor, electrolyte disturbances, renal failure, hyperventilation, tachycardia, bradycardia, dizziness, anxiety, and cough. If you suspect an overdose, it is important to seek immediate medical attention.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage dizziness.

  • Taking the medication with meals can help manage nausea or abdominal pain.

Use in Driving and Operating Machinery

  • This medicine may affect your ability to drive or operate heavy machines. Avoid these activities if you experience dizziness or fatigue after taking this medicine.

Use in Pregnancy and Lactation

  • This medicine is not recommended during pregnancy and breastfeeding unless specifically advised by a healthcare professional due to the lack of specific data. Consult a doctor before taking this medicine during these periods.

Caution in Other Conditions

  • Patients with renal impairment, aortic stenosis, hepatic impairment, hypovolemia, hyperkalemia, or collagen vascular diseases should exercise caution while taking Amlodipine + Perindopril.

Special Dietary and Lifestyle Recommendations

  • Maintain a low-sodium diet to help control your blood pressure.

  • Try to reduce stress through activities like meditation or yoga.

Frequently asked questions

No, Amlodipine + Perindopril is not a steroid. Instead, the combination includes an angiotensin-converting enzyme (ACE) inhibitor and a calcium channel blocker, which work together to manage high blood pressure.

Amlodipine + Perindopril is not directly associated with affecting sleep. However, side effects such as dizziness and fatigue are reported, which could potentially influence sleep patterns.

Amlodipine + Perindopril is not associated with affecting fertility. It is best to discuss this with your doctor if you are concerned.

Amlodipine + Perindopril is typically prescribed to be taken as recommended by your doctor.

The exact time for the medicine to show its effect can vary between individuals. Your doctor can provide a more specific timeline based on your health status and reaction to the medication.

The medicine can be taken at any time of the day as prescribed by your doctor, preferably take it at the same time each day, with or without food.

No, weight gain is not a common side effect of Amlodipine + Perindopril. However, if you notice any unusual changes in your weight, it is advisable to consult your doctor.

Terms & Conditions


Available medicines for AMLODIPINE + PERINDOPRIL
Coversyl Am 8/5 Tablet 10
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Coversyl Am 4/5 Tablet 10
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Cardiomart Ap 5/4 MG Tablet 10
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Coversyl Am 4/10 Tablet 10
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Amtas Prp Tablet 10
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Coversyl Am 8/10 Tablet 10
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Pendicard 4 Am Tablet 10
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