Aspartame

Dosage Forms Available

Aspartame is available for use in the oral route in the form of powder, tablets and granules.

Age and Dose Restrictions

• Aspartame is safe for consumption by both adults and children.

• However, it is always advised to maintain moderation and not exceed the Acceptable Daily Intake (ADI) limit set by the FDA.

Contraindications

• Aspartame is contraindicated in individuals with a rare genetic disorder known as Phenylketonuria (PKU) due to their inability to metabolise phenylalanine, one of the components of Aspartame.

Other Medications to Avoid

• Aspartame can interact with medications affecting phenylalanine levels, such as those used to treat phenylketonuria (e.g., sapropterin) and other medicines that alter amino acid metabolism. It may also interact with medicines affecting methanol metabolism (e.g., fomepizole) and medications impacting central nervous system function (e.g., antiepileptics like phenytoin).

Overdose and Missed Dose

• Overdosing on Aspartame is unlikely due to its low toxicity, but if you believe you have consumed an excessive amount, consult your doctor.

• If you forget to take Aspartame in its tablet form, take it as soon as you remember. But avoid doubling the dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For headaches, try taking your medicine after meals.

• For gastrointestinal symptoms, consider drinking plenty of water and avoid taking this medicine on an empty stomach.

Use in Driving and Operating Machinery

• Aspartame does not impair one's ability to drive or operate heavy machinery.

Use in Pregnancy and Lactation

• Prescribed Aspartame is generally considered safe for use during pregnancy and lactation. However, excessive levels of Aspartame are unsafe in pregnancy. Excessive amounts of Aspartame can also increase the phenylalanine in breast milk in the case of nursing mothers. If you are pregnant or breastfeeding, it is recommended that you consult your doctor before consuming Aspartame.

Caution in Other Conditions

• Those with mood disorders or migraine conditions may need to exercise caution when consuming Aspartame, as it may worsen their symptoms.

Special Dietary and Lifestyle Recommendations

• Maintaining a balanced diet with a variety of fruits, vegetables, whole grains, lean proteins and healthy fats is always recommended.

• Since Aspartame is a low-calorie sweetener, it should not be used as an excuse to increase intake of unhealthy foods that are high in fat, sodium or cholesterol.

• Regular physical activity is also important for overall health.

• If you have diabetes, continue to monitor your blood sugar levels regularly, even if you are using Aspartame as a sugar substitute.