Atorvastatin + Metformin

Dosage Forms Available

• Atorvastatin + Metformin is available for oral administration in the form of tablets.

Age and Dose Restrictions

• This combination is meant for adults and children above the age of 10 years.

Contraindications

• Atorvastatin + Metformin is contraindicated in patients with known hypersensitivity to atorvastatin, metformin, or any component of the formulation.

• It should not be used in patients with active liver disease or unexplained persistent elevations in liver enzymes.

• The combination is also contraindicated in patients with severe renal impairment.

Other Medications to Avoid

• This combination may interact with antibiotics (such as erythromycin and clarithromycin), antifungal medications (like itraconazole and ketoconazole), human immunodeficiency virus (HIV) protease inhibitors (such as ritonavir), medications used to suppress the immune system (like cyclosporine), and calcium channel blockers (such as diltiazem and verapamil).

• It may also interact with antipsychotic medications (like topiramate and zonisamide), carbonic anhydrase inhibitors (like acetazolamide), medicines used to treat chest pain or angina (like ranolazine), antiretroviral medicines (like dolutegravir and vandetanib), and heartburn medication (like cimetidine).

Overdose and Missed Dose

• An overdose of Atorvastatin + Metformin can lead to serious symptoms such as muscle weakness, abdominal pain, rapid breathing, and a slow or irregular heartbeat. If you suspect an overdose, seek immediate medical attention.

• If you miss a dose of Atorvastatin + Metformin, take it as soon as you remember. However, if it is close to your next dose, skip the missed dose and continue with your regular schedule. Do not double your dose to make up for the missed one.

Management of Side Effects

• Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of fluids may help manage side effects like diarrhoea and nausea.

• Taking the medication with or after meals can help reduce gastrointestinal side effects.

Use in Driving and Operating Machinery

• Atorvastatin + Metformin may cause dizziness or lightheadedness. If you experience these symptoms, avoid driving or operating machinery until you feel well again.

Use in Pregnancy and Lactation

• Atorvastatin + Metformin is not recommended during pregnancy unless prescribed by a doctor.

• The medicine can pass into breast milk, so its use is discouraged during breastfeeding.

Caution in Other Conditions

• People with a history of liver or kidney disease should take Atorvastatin + Metformin with caution. Diabetic patients who frequently consume alcohol should also be cautious while taking this medicine.

Special Dietary and Lifestyle Recommendations

• Regular monitoring of blood glucose levels will help track the effectiveness of the medication and manage diabetes better.

• A diet rich in fruits, vegetables, whole grains, lean meats, and low-fat dairy products can help manage diabetes and cholesterol levels.

• Regular physical activity can help control blood glucose levels and maintain a healthy weight.