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Benzalkonium Chloride + Gancyclovir

Uses of Benzalkonium Chloride + Gancyclovir

  • The primary use of Benzalkonium Chloride + Gancyclovir is to manage ocular infections caused by cytomegalovirus (CMV). This medicine belongs to the group of antiviral and antimicrobial medicines.

Side effects of Benzalkonium Chloride + Gancyclovir

  • Ocular irritation

  • Allergic reactions

  • Neutropenia

  • Anemia

  • Fever

How Benzalkonium Chloride + Gancyclovir works

  • Benzalkonium Chloride + Ganciclovir is a combination used in certain ophthalmic preparations.

  • Benzalkonium Chloride is a biocide and preservative. It works by disrupting the cell membranes of microbes. The positively charged cations of the compound interact with negatively charged sites on the microbial cell walls, causing loss of structural integrity, leakage of cell contents, and death of the cells. It also alters proteins and disables enzymes that are essential for the metabolic activities of the cells.

  • Ganciclovir, on the other hand, is an antiviral medication that specifically targets cytomegalovirus (CMV) infections. It is a synthetic analog of guanine which, when inside CMV-infected cells, gets converted into an active form by viral and cellular kinases. This active form inhibits the incorporation of deoxyguanosine triphosphate into viral DNA by the CMV DNA polymerase, thereby terminating viral DNA elongation.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Benzalkonium Chloride + Gancyclovir is principally found in ophthalmic form, intended for use directly in the eyes.

  • These medications are commonly available as eye drops or gels.

  • The route of administration for these forms is topical, applied directly to the eye area.

Age and Dose Restrictions

  • This medicine is primarily meant for adult use.

  • It is typically prescribed for adults suffering from specific eye infections like CMV retinitis, especially in immunocompromised patients.

Contraindications

  • Benzalkonium Chloride + Gancyclovir is contraindicated in patients with known hypersensitivity to either benzalkonium chloride or ganciclovir.

  • It is also contraindicated in individuals with a history of severe allergic reactions to other antiviral or antimicrobial agents.

Other Medications to Avoid

  • This combination may interact with other topical beta-blockers (such as betaxolol), prostaglandin analogs (like latanoprost), and topical decongestants (such as naphazoline). These interactions may increase the risk of eye irritation, dryness, or excessive intraocular pressure reduction, leading to potential discomfort or ocular surface damage.

Overdose and Missed Dose

  • An overdose of Benzalkonium Chloride + Gancyclovir eye drops might result in increased eye irritation, redness, or discomfort. If these symptoms occur, flushing the eye with room temperature water and consulting a doctor are recommended.

  • If you miss a dose of this medicine, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule without doubling up.

  • In case you happen to put a few extra drops of this medicine in your eye, do not panic. Rinse your eyes with clean water at room temperature. If any symptoms persist or worsen, inform your doctor.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If experiencing mild irritation from the eye drops, try applying them at a different time when you can rest your eyes post-application.

  • Ensure sufficient hydration which may help alleviate mild irritation.

Use in Driving and Operating Machinery

  • The use of Benzalkonium Chloride + Gancyclovir may cause temporary blurring of vision due to its application in the eye. It is advisable to avoid driving or operating heavy machinery until your vision has cleared and you are sure that your ability is not compromised.

Use in Pregnancy and Lactation

  • The safety of Benzalkonium Chloride + Gancyclovir during pregnancy and lactation has not been fully established.

  • It is recommended to consult your doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Individuals with pre-existing eye conditions such as glaucoma or severe dry eye syndrome should use Benzalkonium Chloride + Gancyclovir with caution.

  • Caution is also advised for patients with severe renal impairment due to the potential systemic absorption of ganciclovir.

Special Dietary and Lifestyle Recommendations

  • Maintain optimal hydration to help manage medication side effects and support overall eye health.

  • Incorporate foods rich in vitamins A and C into your diet to support immune function and eye health. Consider orange-coloured fruits like carrots and oranges which are high in vitamin A.

  • Manage stress through relaxation techniques such as meditation or yoga, which can indirectly help maintain immune function, beneficial for those dealing with viral infections.

  • Avoid smoking or exposure to smoke; smoking can exacerbate eye conditions and interfere with the effectiveness of ophthalmic treatments.

Frequently asked questions

Benzalkonium Chloride + Gancyclovir is not a steroid.

Benzalkonium Chloride + Gancyclovir works by combining antiviral and antimicrobial properties. Benzalkonium chloride inhibits microbial growth, while ganciclovir disrupts viral DNA elongation, thus managing CMV infections.

Benzalkonium Chloride + Gancyclovir usually requires a prescription and is typically not available over the counter.

No specific information suggests that Benzalkonium Chloride + Gancyclovir causes sleep disturbances. However, any unusual symptoms should be reported to your doctor immediately.

It is usually advised to use Benzalkonium Chloride + Gancyclovir for the duration recommended by your doctor. Long-term use may have potential adverse effects and should be avoided unless specifically advised by your doctor.

Benzalkonium Chloride + Gancyclovir does not interact with male or female fertility.

The best time to use Benzalkonium Chloride + Gancyclovir will be mentioned by your doctor.

Terms & Conditions


Benzalkonium Chloride + Gancyclovir in other salts

GANCYCLOVIRBENZALKONIUM CHLORIDE + CHOLINE SALICYLATE + LIDOCAINE / LIGNOCAINEBENZALKONIUM CHLORIDE + ZINC OXIDEBENZALKONIUM CHLORIDE + BROMFENAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + OFLOXACINBENZALKONIUM CHLORIDE + CYCLOPENTOLATEBENZALKONIUM CHLORIDE + CIPROFLOXACINBENZALKONIUM CHLORIDE + CIPROFLOXACIN + DEXAMETHASONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONE + TOBRAMYCINBENZALKONIUM CHLORIDE + GATIFLOXACINBENZALKONIUM CHLORIDE + DEXAMETHASONE + OFLOXACINBENZALKONIUM CHLORIDE + NEPAFENACBENZALKONIUM CHLORIDE + MOXIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + TOBRAMYCINBENZALKONIUM CHLORIDE + CHOLINE SALICYLATEBENZALKONIUM CHLORIDE + DEXAMETHASONE + TOBRAMYCINBENZALKONIUM CHLORIDE + BRIMONIDINE + TIMOLOLALCAFTADINE + BENZALKONIUM CHLORIDEBENZALKONIUM CHLORIDE + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + FLUCONAZOLEBENZALKONIUM CHLORIDE + KETOROLAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + LATANOPROSTBENZALKONIUM CHLORIDE + OLOPATADINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + BRIMONIDINEBENZALKONIUM CHLORIDE + PHENYLEPHRINE + TROPICAMIDEBENZALKONIUM CHLORIDE + BEPOTASTINEBENZALKONIUM CHLORIDE + BRIMONIDINE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + BIMATOPROSTBENZALKONIUM CHLORIDE + BIMATOPROST + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + CYCLOSPORINBENZALKONIUM CHLORIDE + KETOROLAC + OLOPATADINEBENZALKONIUM CHLORIDE + DORZOLAMIDEBENZALKONIUM CHLORIDE + DORZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + GATIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + LATANOPROST + TIMOLOLBENZALKONIUM CHLORIDE + LOTEPREDNOLBENZALKONIUM CHLORIDE + LOTEPREDNOL + TOBRAMYCINBENZALKONIUM CHLORIDE + DEXAMETHASONE + MOXIFLOXACINBENZALKONIUM CHLORIDE + LOTEPREDNOL + MOXIFLOXACINBENZALKONIUM CHLORIDE + BROMFENACBENZALKONIUM CHLORIDE + MOXIFLOXACINBENZALKONIUM CHLORIDE + OLOPATADINEBENZALKONIUM CHLORIDE + PREDNISOLONEBENZALKONIUM CHLORIDE + TIMOLOL + TRAVOPROSTBENZALKONIUM CHLORIDE + TRAVOPROSTBENZALKONIUM CHLORIDE + NATAMYCINBENZALKONIUM CHLORIDE + CAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + NETARSUDIL
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