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Benzalkonium Chloride + Natamycin

Uses of Benzalkonium Chloride + Natamycin

  • Benzalkonium Chloride + Natamycin is primarily used as a potent antifungal agent for treating fungal eye infections.

  • Secondary applications of this combination include the use of Benzalkonium chloride as an antimicrobial preservative in various products like antibacterial soaps, sanitisers, and cleaning agents.

Side effects of Benzalkonium Chloride + Natamycin

  • Eye irritation

  • Discomfort or stinging sensation in the eyes

  • Temporary blurred vision

  • Possible allergic reactions such as rash, itching, and swelling

  • Severe dizziness

How Benzalkonium Chloride + Natamycin works

  • Benzalkonium Chloride + Natamycin is a combination of an antimicrobial and an antifungal.

  • Benzalkonium chloride is a quaternary ammonium compound. It works by disrupting the cellular membrane of bacteria. This alters the cell's permeability, causing leakage of essential cellular contents and deactivating enzymes responsible for regulating respiratory and metabolic activities in cells.

  • Natamycin is a naturally occurring antifungal agent. It works by binding to ergosterol, a crucial component of fungal cell membranes. This disrupts the membrane integrity, leading to leakage of cellular contents, inhibiting fungal growth, and eventually causing cell death.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Benzalkonium Chloride + Natamycin is available as an eye drop solution.

  • This formulation is intended for topical application to the eyes.

Age and Dose Restrictions

  • This medicine is meant for use in adults and children aged two years and older.

Contraindications

  • This medicine is contraindicated in patients with known hypersensitivity to benzalkonium chloride or natamycin.

  • It is also contraindicated in patients with viral, bacterial, or parasitic eye infections other than fungal.

Other Medications to Avoid

  • This combination may interact with other topical beta-blockers (such as betaxolol), prostaglandin analogs (like latanoprost), and topical decongestants (such as naphazoline). These interactions may increase the risk of eye irritation, dryness, or excessive intraocular pressure reduction, leading to potential discomfort or ocular surface damage.

Overdose and Missed Dose

  • An overdose of Benzalkonium Chloride + Natamycin may lead to excessive eye irritation and discomfort. If an overdose occurs, it is recommended to flush the eyes with clean water. If irritation persists, contact your doctor.

  • If you forget to apply a dose of this medicine, apply it as soon as you remember. If it is nearly time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not apply double doses to make up for a missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If eye irritation or discomfort occurs, ensure to rinse the eyes gently with water.

  • Taking breaks between long uses can help reduce discomfort.

Use in Driving and Operating Machinery

  • This medication may temporarily blur vision after application. You should wait until your vision clears before driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • The safety of Benzalkonium Chloride + Natamycin during pregnancy and lactation has not been fully established. It should be used only when clearly needed under the advice of a doctor.

  • Consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Caution is advised when using this medication in individuals with severe allergies or asthma, as benzalkonium chloride can cause bronchial constriction.

Special Dietary and Lifestyle Recommendations

  • It is important to maintain good hygiene by washing hands thoroughly before applying eye drops to prevent additional contamination or infection.

  • Avoid wearing contact lenses during treatment with Benzalkonium Chloride + Natamycin unless specifically advised by a doctor. Contact lenses can absorb preservatives in the drops which might lead to eye irritation.

  • Ensure that you do not touch the tip of the dropper bottle to any surface, including the eyes or hands, to prevent contamination of the solution.

Frequently asked questions

No, Benzalkonium Chloride + Natamycin is not effective against bacterial infections. Benzalkonium chloride is an antimicrobial preservative while natamycin is an antifungal agent used specifically for treating fungal eye infections.

Rare but serious side effects of natamycin eye drops may include allergic reactions, such as rash, itching, swelling, severe dizziness, or trouble breathing. If you notice any signs of an allergic reaction after applying this medicine, discontinue use and consult your doctor immediately.

Benzalkonium Chloride + Natamycin is usually found in the form of eye drops and ointments for topical application. Always follow your doctor's instructions on how to properly administer this medication.

Benzalkonium Chloride + Natamycin is not a steroid.

Patients are usually advised not to wear contact lenses during treatment with natamycin eye drops to prevent further irritation and ensure effective treatment.

Ingestion of benzalkonium chloride may be fatal in humans. If accidental ingestion occurs, seek immediate medical help.

There are no known significant medicinal interactions between benzalkonium chloride and natamycin. However, if you're using multiple eye medications, it's advised to wait at least 5 minutes between applying different products to allow proper absorption.

Terms & Conditions


Benzalkonium Chloride + Natamycin in other salts

BENZALKONIUM CHLORIDE + CHOLINE SALICYLATE + LIDOCAINE / LIGNOCAINEBENZALKONIUM CHLORIDE + ZINC OXIDEBENZALKONIUM CHLORIDE + BROMFENAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + OFLOXACINBENZALKONIUM CHLORIDE + CYCLOPENTOLATEBENZALKONIUM CHLORIDE + CIPROFLOXACINBENZALKONIUM CHLORIDE + CIPROFLOXACIN + DEXAMETHASONENATAMYCINBENZALKONIUM CHLORIDE + FLUOROMETHOLONEBENZALKONIUM CHLORIDE + FLUOROMETHOLONE + TOBRAMYCINBENZALKONIUM CHLORIDE + GATIFLOXACINBENZALKONIUM CHLORIDE + DEXAMETHASONE + OFLOXACINBENZALKONIUM CHLORIDE + NEPAFENACBENZALKONIUM CHLORIDE + MOXIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + TOBRAMYCINBENZALKONIUM CHLORIDE + CHOLINE SALICYLATEBENZALKONIUM CHLORIDE + DEXAMETHASONE + TOBRAMYCINBENZALKONIUM CHLORIDE + BRIMONIDINE + TIMOLOLALCAFTADINE + BENZALKONIUM CHLORIDEBENZALKONIUM CHLORIDE + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + FLUCONAZOLEBENZALKONIUM CHLORIDE + KETOROLAC + MOXIFLOXACINBENZALKONIUM CHLORIDE + LATANOPROSTBENZALKONIUM CHLORIDE + OLOPATADINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + BRIMONIDINEBENZALKONIUM CHLORIDE + PHENYLEPHRINE + TROPICAMIDEBENZALKONIUM CHLORIDE + BEPOTASTINEBENZALKONIUM CHLORIDE + BRIMONIDINE + BRINZOLAMIDEBENZALKONIUM CHLORIDE + BIMATOPROSTBENZALKONIUM CHLORIDE + BIMATOPROST + TIMOLOLBENZALKONIUM CHLORIDE + BRINZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + CYCLOSPORINBENZALKONIUM CHLORIDE + KETOROLAC + OLOPATADINEBENZALKONIUM CHLORIDE + DORZOLAMIDEBENZALKONIUM CHLORIDE + DORZOLAMIDE + TIMOLOLBENZALKONIUM CHLORIDE + GATIFLOXACIN + PREDNISOLONEBENZALKONIUM CHLORIDE + LATANOPROST + TIMOLOLBENZALKONIUM CHLORIDE + LOTEPREDNOLBENZALKONIUM CHLORIDE + LOTEPREDNOL + TOBRAMYCINBENZALKONIUM CHLORIDE + DEXAMETHASONE + MOXIFLOXACINBENZALKONIUM CHLORIDE + LOTEPREDNOL + MOXIFLOXACINBENZALKONIUM CHLORIDE + BROMFENACBENZALKONIUM CHLORIDE + MOXIFLOXACINBENZALKONIUM CHLORIDE + OLOPATADINEBENZALKONIUM CHLORIDE + PREDNISOLONEBENZALKONIUM CHLORIDE + TIMOLOL + TRAVOPROSTBENZALKONIUM CHLORIDE + TRAVOPROSTBENZALKONIUM CHLORIDE + CAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + NETARSUDILBENZALKONIUM CHLORIDE + GANCYCLOVIR
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