The primary use of Berberine is to manage diabetes by lowering blood sugar levels. It belongs to the class of plant-based alkaloids.
Secondary uses of Berberine include managing high cholesterol and triglycerides, high blood pressure, heart health, polycystic ovary syndrome (PCOS), canker sores, Helicobacter pylori infection, and digestive issues like diarrhoea.
Digestive symptoms like diarrhoea, constipation, gas, nausea, and abdominal pain
Headache
Skin rash
Burning sensation when applied topically
Berberine is a type of plant alkaloid. It works by activating an enzyme known as AMPK which plays a crucial role in regulating your body's metabolism. Berberine also aids in improving insulin sensitivity enabling cells to utilise glucose more efficiently. It helps to reduce insulin resistance in muscles, contributing to better glucose management.
Doctor of Medicine
BMS, FMC, MD Resident
Berberine is available for oral administration in the form of capsules, tablets, powders, and liquid extracts.
For topical application, particularly for canker sores, Berberine is available as a gel.
Berberine is typically used by adults of age above 18 years. It should not be given to newborns due to the potential risk of worsening jaundice. Children should only take Berberine under strict doctor supervision.
Individuals with severe liver or kidney disease should avoid taking Berberine.
This medicine is also contraindicated in patients with bowel obstruction and acute gallbladder or digestive inflammation.
Berberine may interact with diabetes medications (like insulin or metformin), high blood pressure medications (like ACE inhibitors or beta-blockers), antibiotics (such as azithromycin), antifungals (like fluconazole), sedatives (like benzodiazepines), blood thinners (such as warfarin), and immunosuppressant medication such as cyclosporine.
Overdosing on Berberine can cause symptoms such as lethargy, difficulty breathing, skin flushing or low blood pressure. If you suspect an overdose, seek medical attention immediately.
If you miss a dose of Berberine, take it as soon as you remember. Do not double up on doses to compensate for a missed dose.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage digestive symptoms such as constipation or abdominal pain.
Resting in a quiet, dimly lit room may help relieve headaches.
If you experience skin rash, avoid scratching or rubbing the affected area.
Berberine may cause dizziness or fatigue in some people. If you experience these effects, do not drive or operate heavy machinery until you feel capable.
Berberine should be avoided during pregnancy and breastfeeding due to potential risks to the baby. Always consult your doctor before taking this medicine if you are pregnant or nursing.
Individuals with low blood pressure should exercise caution when taking Berberine as it may further lower blood pressure.
If you have a scheduled surgery, discontinue the use of Berberine two weeks before the procedure.
Maintain a balanced diet rich in fruits, vegetables, lean proteins and whole grains to support overall health.
Regular physical activity can help manage conditions like diabetes, high cholesterol and high blood pressure, which are often managed with Berberine.
Make sure you get adequate sleep each night, as lack of sleep can exacerbate many health conditions.
Frequently asked questions
Yes, Berberine is a natural compound. It is a plant-based alkaloid found in various plants like European barberry, goldenseal, goldthread, Oregon grape, tree turmeric, and Phellodendron.
There is evidence suggesting that Berberine can aid in weight loss by improving metabolism and reducing inflammation. However, it should not be considered a substitute for a healthy diet and regular exercise. Always consult your doctor before taking any supplement for weight loss.
While Berberine is not a stimulant or energy booster, it can help improve your body's metabolic functions by activating the AMPK enzyme, which regulates energy production in cells.
Most studies have tested the use of Berberine for up to 6 months. The safety of its use beyond this period is not confirmed. It is recommended to consult your doctor before using any supplements long-term.
Berberine is not directly associated with affecting mood. However, as it can help manage blood sugar levels, it might indirectly improve mood by preventing blood sugar crashes that can cause irritability and mood swings.
Berberine is found in several plants, including European barberry, goldenseal, goldthread, Oregon grape, tree turmeric and phellodendron.
Berberine is typically available as a supplement over the counter. However, it is vital to consult your doctor before starting to take it, due to its potential interactions with other medications and health conditions.
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