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Capecitabine

Uses of Capecitabine

  • The main use of Capecitabine is for the management of various types of cancer, including colorectal cancer, breast cancer, and stomach cancer. This medication belongs to the class of antimetabolites.

  • Besides this, it is also used to manage other malignancies when first-line treatments are not effective.

Side effects of Capecitabine

  • Diarrhoea

  • Nausea

  • Mouth sores

  • Vomiting

  • Fatigue

How Capecitabine works

  • Capecitabine is an antimetabolite medication.

  • It starts as a prodrug, which means the body transforms it into an active form called 5-fluorouracil (5-FU). This transformation primarily happens in tumour tissues. Once active, 5-FU interferes with a crucial enzyme for cancer cell growth called thymidylate synthase. This enzyme helps synthesise DNA and RNA. By disrupting its function, Capecitabine inhibits the cancer cells from growing and multiplying, leading to their eventual death.

Certified content

Written By

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Dr Vatsalya D GhanekarMedical Content Writer| 5 years

MD Ayurveda

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Capecitabine can be taken orally (tablet).

Age and Dose Restrictions

  • This medicine is primarily meant for adults. It can be used in children, but only when specifically advised by a doctor.

Contraindications

  • Capecitabine is contraindicated in patients with severe kidney impairment. It is also contraindicated in patients who are known to have dihydropyrimidine dehydrogenase (DPD) deficiency.

Other Medications to Avoid

  • Capecitabine may interact with anticoagulants (warfarin), anti-seizure medications (phenytoin), and certain gout medications (allopurinol).

Overdose and Missed Dose

  • Overdosing on Capecitabine can lead to severe side effects such as diarrhea, nausea, vomiting, stomach pain, and fever. If you suspect an overdose, contact your doctor immediately.

  • If you miss a dose of Capecitabine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of fluids can help manage diarrhea and prevent dehydration.

  • For nausea or vomiting, try taking the medicine after meals.

  • For hand-foot syndrome (redness and swelling of the palms and soles), use a good moisturiser and avoid activities that cause friction or pressure on the hands and feet.

Use in Driving and Operating Machinery

  • Capecitabine may cause dizziness or fatigue in some people. If you experience these side effects, avoid driving or operating machinery until you feel better.

Use in Pregnancy and Lactation

  • Capecitabine may harm a developing fetus and should not be used during pregnancy unless specifically recommended by a doctor. It is recommended to avoid breastfeeding while taking this medicine.

Caution in Other Conditions

  • Caution should be exercised when using Capecitabine in patients with liver disease or a history of heart disease.

Special Dietary and Lifestyle Recommendations

  • Drink plenty of fluids to prevent dehydration, especially if you are experiencing diarrhea or vomiting.

  • Try to stay active with light physical activities such as walking, which can help combat fatigue caused by chemotherapy.

  • Keep your hands and feet moisturised to help manage hand-foot syndrome.

Frequently asked questions

No, Capecitabine is not a steroid. It is an oral chemotherapy medicine that belongs to the class of medications known as antimetabolites.

There is no specific information indicating that Capecitabine directly influences sleep patterns. However, side effects like fatigue might indirectly affect your sleep. If you experience significant sleep disturbances, it is advisable to consult your doctor.

Some chemotherapy medicines can have an impact on fertility, and this could potentially be a concern with Capecitabine as well. If you have fertility concerns, it would be best to discuss these with your doctor before starting Capecitabine.

The frequency and duration of taking Capecitabine should always be determined by your doctor.

The time taken for Capecitabine to work can vary based on individual patient factors and the type of cancer being managed. Evaluating the response to treatment usually involves regular monitoring by your doctor and may include various diagnostic tests.

No, you cannot buy Capecitabine over the counter. It is a prescription medication and should only be taken under the supervision of a doctor.

Capecitabine should be taken in the dose and duration as advised by the doctor.

Terms & Conditions

Available medicines for CAPECITABINE
Capegard 500 MG Tablet 10
Capegard 500 MG Tablet 10
Cipla Ltd.
Pack of 10 Units
₹734.19
MRP ₹895.35
18.00% OFF
Capetero 500 Tablet 10
Capetero 500 Tablet 10
Hetero Healthcare Ltd
Pack of 10 Units
₹1287.40
MRP ₹1570.00
18.00% OFF
Capcel 500 MG Tablet 10
Capcel 500 MG Tablet 10
Celon Labs
Pack of 10 Units
₹1082.40
MRP ₹1320.00
18.00% OFF
Capsy 500 Tablet 10
Capsy 500 Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹1035.18
MRP ₹1262.42
18.00% OFF
Capecitime 500 Tablet 10
Capecitime 500 Tablet 10
Steris Healthcare
Pack of 10 Units
₹647.70
MRP ₹1298.00
50.10% OFF
Capiibine Tablet 30
Capiibine Tablet 30
Dr. Reddys Laboratories Ltd
Pack of 30 Units
₹2836.61
MRP ₹3459.28
18.00% OFF
Capad Tablet 10
Capad Tablet 10
Oncocare Scientifics Pvt Ltd
Pack of 10 Units
₹72.98
MRP ₹89.00
18.00% OFF
Xeloda 500mg Tablet 10
Xeloda 500mg Tablet 10
Roche
Pack of 10 Units
₹1312.65
MRP ₹1353.25
3.00% OFF

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