Carvedilol + Ivabradine

Dosage Forms Available

• Carvedilol + Ivabradine is available as tablet for oral administration.

Age and Dose Restrictions

• This medicine is intended for use in adults over 18 years of age.

Contraindications

Patients with the following conditions should not take Carvedilol + Ivabradine:

• Severe liver failure
• Symptoms of heart failure
• Blood pressure less than 90/50 mmHg
• Complete heart block (unless a functioning pacemaker is present)
• Resting heart rate less than 60 beats per minute prior to treatment
• Severe Chronic Obstructive Pulmonary Disease (COPD)
• Cardiogenic shock where the heart is unable to pump enough blood to the rest of the body
• Or a history of serious hypersensitivity reaction to either component of the medication.

Other Medications to Avoid

• Carvedilol + Ivabradine may interact with other medications for high blood pressure or heart problems, with antibiotics (e.g., clarithromycin and telithromycin), antifungals (e.g., itraconazole and ketoconazole), antidepressants (e.g., nefazodone), anti-HIV medications (e.g., ritonavir), anti-seizure medications (e.g., phenobarbital and phenytoin), and herbal supplements (e.g., St. John's Wort).
• Before starting any prescription or over-the-counter medicines, it is crucial to consult your doctor as certain combinations can lead to potentially harmful interactions.

Overdose and Missed Dose

• Overdose of this medication may result in symptoms such as dizziness, slow heartbeat, breathing difficulties, and fainting. If you suspect an overdose, seek immediate medical attention.
• If you miss a dose of Carvedilol + Ivabradine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water may help manage some common side effects such as dry mouth and constipation.
• If you experience dizziness upon standing, try getting up slowly from a sitting or lying position.

Use in Driving and Operating Machinery

• Carvedilol + Ivabradine may cause side effects such as dizziness and fatigue which could affect your ability to drive or operate heavy machinery. Therefore, avoid these activities until you know how this medicine affects you.

Use in Pregnancy and Lactation

• Use of Carvedilol + Ivabradine during pregnancy or breastfeeding should be avoided unless recommended by your doctor. Consult your doctor before using this medicine if you are pregnant or nursing.

Caution in Other Conditions

• Patients with known allergies to either component medication, asthma or other breathing problems, very low blood pressure (hypotension), severe liver problems, kidney problems, diabetes, thyroid disorders, or certain eye problems like retinitis pigmentosa should exercise caution while taking Carvedilol + Ivabradine.

Special Dietary and Lifestyle Recommendations

• Maintain a low-sodium diet to better manage high blood pressure.
• Limit alcohol intake as it can further lower blood pressure and may increase certain side effects of Carvedilol + Ivabradine.
• Regular physical activity can help control high blood pressure.
• Try to manage stress through techniques such as relaxation exercises and meditation.