Cefepime + Tazobactam is primarily used for managing certain types of bacterial infections. This combination belongs to antibiotic medicines.
It is also effective in managing complicated intra-abdominal infections, complicated urinary tract infections, hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia in adults as well as in paediatric patients aged 2 months and older.
Diarrhoea
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Cefepime belongs to the fourth-generation cephalosporin antibiotics that work by attaching to and deactivating proteins that bacteria need to build their cell walls, disrupting the cross-linking of peptidoglycan, a key component of the bacterial cell wall.
Tazobactam is a β-lactamase inhibitor. It works by attaching itself to and disabling β-lactamase enzymes produced by bacteria. These enzymes would otherwise break down antibiotics like cefepime, making these antibiotics ineffective.
Doctor of Medicine
BMS, FMC, MD Resident
Cefepime + Tazobactam is available for use via the intravenous route (powder which needs reconstitution into a solution).
This medicine is indicated for adult patients and also for paediatric patients aged 2 months and above.
Cefepime + Tazobactam is contraindicated in patients with known severe hypersensitivity to Cefepime, Tazobactam, other cephalosporins, penicillins, or β-lactamase inhibitors.
This combination may interact with diuretics (eg., furosemide and thiazides), live bacterial vaccines (eg., BCG, typhoid), anticoagulants (eg., warfarin), and neuromuscular blockers (eg., pancuronium).
Chances for overdose are less as it is administered to you by a healthcare professional. However, an overdose of this medication may cause severe nausea, vomiting, or diarrhoea. If you observe any such symptoms, inform your doctor immediately.
If you forget to administer a dose, consult your healthcare provider for the next dose.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects like constipation.
Resting and limiting physical activity can alleviate feelings of fatigue.
This medication may cause dizziness or confusion. If you feel affected, avoid driving or operating heavy machinery.
It is advised to consult your doctor before using this medicine combination during breastfeeding and pregnancy.
Patients with severe renal impairment, severe hepatic disease, or a history of seizures should exercise caution when administering this medicine.
As the preparation contains sodium, care should be administered in patients on a high-sodium diet or those with conditions such as congestive heart failure or hypertension.
Maintain adequate hydration throughout the course of treatment, especially in patients with compromised renal function.
Patients with conditions like hypertension, heart failure, or kidney disease should monitor and potentially reduce sodium intake from other sources to avoid complications such as fluid retention or worsening heart function.
Consider incorporating probiotic-rich foods (e.g., yoghurt, kefir, sauerkraut) or taking probiotic supplements to help restore gut flora during and after treatment.
If treating a severe infection, adequate rest is crucial to support the body's immune response. Avoid strenuous physical activity during the course of treatment, especially if you're feeling fatigued or unwell.
Frequently asked questions
Unopened vials of Cefepime + Tazobactam should be stored at a controlled room temperature between 20°C to 25°C. After reconstitution, the solutions are stable for 24 hours at room temperature or can be refrigerated for up to 7 days.
One of the common side effects of Cefepime + Tazobactam is insomnia. So yes, this medicine might affect sleep in some individuals.
Cefepime + Tazobactam is not directly associated with affecting fertility. However, if you are planning to conceive or have concerns about fertility, it is highly recommended to consult your doctor.
Yes, provided it is prescribed by your doctor. The dosage and duration of treatment would depend on the type and severity of the infection.
The time taken for this medicine to act might vary depending on the type and severity of infection. For best results, it is essential to take the medication as prescribed by your doctor.
Your doctor will advise you on the time to administer this medicine based on your medical condition and response to therapy.
Cefepime + Tazobactam is a prescription medication and should be used only under the guidance of a medical professional.
Cefepime + Tazobactam in other salts
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