Cefoperazone + Tazobactam
Uses of Cefoperazone + Tazobactam
Cefoperazone + Tazobactam is mainly used to manage various bacterial infections (such as intra-abdominal infections, respiratory tract infections, skin infections, urinary tract infections, septicaemia, and bacterial meningitis). It belongs to the group of cephalosporin antibiotics.
Side effects of Cefoperazone + Tazobactam
Diarrhoea
Nausea
Vomiting
Abdominal pain
Local injection site reactions
How Cefoperazone + Tazobactam works
Cefoperazone + Tazobactam is a combination antibiotic.
Cefoperazone, a third-generation cephalosporin, works by inhibiting bacterial cell wall synthesis. It attaches to and inactivates penicillin-binding proteins (PBPs), which are enzymes involved in the synthesis of bacterial cell walls. It, thus, weakens the cell wall, causing the cell to break apart and die.
Tazobactam is a beta-lactamase inhibitor. Some bacteria produce beta-lactamase enzymes that can deactivate antibiotics like cefoperazone. Tazobactam prevents these enzymes from working, thus protecting cefoperazone and allowing it to kill bacteria that produce beta-lactamase.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Cefoperazone + Tazobactam is administered through the intravenous route, meaning it is injected directly into a vein.
Age and Dose Restrictions
It is intended for use in adults. The dosage varies based on the type and severity of the infection to be managed.
Contraindications
This combination is contraindicated in patients with known hypersensitivity to either cefoperazone or tazobactam.
It is also contraindicated in those with a known allergy to other beta-lactam antibiotics, such as penicillins or cephalosporins.
Other Medications to Avoid
This combination can interact with aminoglycoside antibiotics (such as gentamicin and amikacin), anticoagulants (like warfarin and heparin), and gout medications (such as probenecid).
It's also essential to avoid concurrent use of this combination with live bacterial vaccines (for example, typhoid vaccine).
Overdose and Missed Dose
An overdose of Cefoperazone + Tazobactam can lead to nausea, vomiting, diarrhoea, and abdominal pain. If you suspect an overdose, please consult your doctor immediately.
If you miss a dose of this medicine, consult your doctor for the next dose. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage diarrhoea and nausea associated with this medication.
Use in Driving and Operating Machinery
It may cause drowsiness and dizziness. Avoid driving or operating heavy machinery while on this medication.
Use in Pregnancy and Lactation
The safety of Cefoperazone + Tazobactam during pregnancy and breastfeeding is not well established. Therefore, it is advised to consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with renal impairment should exercise caution when using this combination, as dosage adjustments may be necessary based on the creatinine clearance.
Those with a history of gastrointestinal diseases, particularly colitis, should use this medicine with caution.
Special Dietary and Lifestyle Recommendations
To prevent bacterial infections, maintain good hygiene practices such as regular hand washing.
Consuming a balanced diet rich in fruits, vegetables, lean proteins, and whole grains can support overall health and immune function.
Frequently asked questions
Is Cefoperazone + Tazobactam an over-the-counter medicine, or do I need a prescription?
Cefoperazone + Tazobactam is not an over-the-counter medicine. It requires a prescription from a registered doctor to be purchased.
Does Cefoperazone + Tazobactam cause sleep disturbances?
There is no direct link between using Cefoperazone + Tazobactam and experiencing sleep disturbances. However, if you feel excessively sleepy or restless after the medication, kindly consult your doctor.
Is Cefoperazone + Tazobactam safe for long-term use?
Long-term use of any antibiotic, including Cefoperazone + Tazobactam, should be done under medical supervision as it can lead to resistance and reduce the effectiveness of the medication.
Will using Cefoperazone + Tazobactam affect my menstrual cycle?
There are no known direct effects of Cefoperazone + Tazobactam on the menstrual cycle. However, if you observe any irregularities in your period, please consult your doctor.
Is it safe to consume alcohol while using Cefoperazone + Tazobactam?
Avoid consuming alcohol while on this medication as a disulfiram-like reaction characterised by flushing, sweating, and headache has been reported in some individuals.
Can I take home remedies or herbal supplements with Cefoperazone + Tazobactam?
Before starting any new supplement or remedy while on this medication, it is best to consult your doctor to avoid potential interactions.
Will using Cefoperazone + Tazobactam affect my mood or energy levels?
The medication does not have any known effects on mood or energy levels. If you experience any mood changes or fatigue after starting this medication, please consult your doctor.
Cefoperazone + Tazobactam in other salts
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