Cefotaxime + Sulbactam
Uses of Cefotaxime + Sulbactam
The primary use of Cefotaxime + Sulbactam is to manage serious bacterial infections in different body sites. It belongs to the class of antibiotic medications.
It is also used for managing lower respiratory tract infections such as pneumonia and bronchitis, urinary tract infections, skin and soft tissue infections, bone and joint infections, intra-abdominal infections like peritonitis, pelvic inflammatory disease, bacterial septicemia, meningitis, and also for surgical prophylaxis.
Side effects of Cefotaxime + Sulbactam
Injection site reactions
Nausea and vomiting
Diarrhoea
Rash or other skin reactions
Elevated liver enzymes
How Cefotaxime + Sulbactam works
Cefotaxime is a third-generation cephalosporin antibiotic. It works by preventing the creation of bacterial cell walls, necessary components for their survival. It attaches itself to proteins that are crucial for these cell walls' formation, causing disruption and leading to the death of the bacteria.
Sulbactam is a beta-lactamase inhibitor. Certain bacteria produce beta-lactamase enzymes that break down antibiotics like cefotaxime, making them ineffective. Sulbactam prevents this process by binding to these enzymes and stopping their function. This protection allows cefotaxime to stay active and combat bacteria that resist antibiotics due to their ability to produce beta-lactamase enzymes.
Certified content
Written By
MD Ayurveda
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Cefotaxime + Sulbactam can be administered intravenously or intramuscularly (injection).
Age and Dose Restrictions
Cefotaxime + Sulbactam is typically used in adults, although it can also be given to children if required under medical supervision.
Contraindications
This medicine is contraindicated in patients with known allergies to cefotaxime, sulbactam, or any other cephalosporin or penicillin-group antibiotics.
Other Medications to Avoid
This combination may interact with aminoglycoside antibiotics (such as gentamicin and amikacin), loop diuretics (like furosemide and bumetanide), and anticoagulants (such as warfarin and heparin).
Overdose and Missed Dose
Overdose of Cefotaxime + Sulbactam can cause neurological reactions like encephalopathy and convulsions, particularly in patients with renal impairment. If you suspect an overdose, inform your doctor immediately.
If you forget to take your dose, take it as soon as you remember. However, do not double up on doses to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
For gastrointestinal disturbances like nausea and diarrhoea, try taking this medicine with food or milk.
To manage injection site reactions like pain and thrombophlebitis, apply a cold pack to the injection site.
Use in Driving and Operating Machinery
This medicine may cause side effects like dizziness, which can affect your ability to drive or operate heavy machinery. Avoid these activities if you experience any such symptoms.
Use in Pregnancy and Lactation
This medicine should be used in pregnancy only if clearly needed. Low concentrations of cefotaxime are excreted in human milk. Caution should be exercised when administered to nursing women. Always consult your doctor before use.
Caution in Other Conditions
Patients with renal impairment or liver disease should exercise caution when taking this medicine as it may require dose adjustment.
Individuals on anticoagulant therapy should also be cautious as this medicine may increase the prothrombin time.
Special Dietary and Lifestyle Recommendations
Maintaining good hydration can help manage potential side effects like diarrhoea and vomiting.
Regularly cleaning the injection site can help prevent skin reactions.
For patients with urinary tract infections, drinking cranberry juice might help by preventing bacteria from sticking to the urinary tract walls.
Frequently asked questions
Is Cefotaxime + Sulbactam a steroid?
No, Cefotaxime + Sulbactam is not a steroid. It is an antibiotic medication which comprises two active ingredients: Cefotaxime, a third-generation cephalosporin antibiotic, and Sulbactam, a beta-lactamase inhibitor.
Does Cefotaxime + Sulbactam have any effect on sleep?
There is no specific information suggesting that Cefotaxime + Sulbactam affects sleep. However, as with any medication, different individuals may react differently. If you experience significant sleep disturbances after starting this medication, consult your doctor.
Will Cefotaxime + Sulbactam affect fertility?
There is no clear evidence to suggest that Cefotaxime + Sulbactam impacts fertility in men or women. However, if you are planning to conceive or have experienced fertility issues while using this medication, please consult with your doctor.
Is it safe to take Cefotaxime + Sulbactam daily?
Cefotaxime + Sulbactam should be taken as prescribed by your doctor. The frequency and duration of use will depend on the type and severity of the infection being managed.
How much time does Cefotaxime + Sulbactam take to work?
The time for Cefotaxime + Sulbactam to start working can vary depending on the type of infection and its severity. Always follow your doctor’s instructions and complete the full course of the medication.
What is the best time to take Cefotaxime + Sulbactam?
Cefotaxime + Sulbactam should be taken as directed by your doctor. It is usually administered every 8 to 12 hours, with the exact timing depending on the severity of the infection being managed.
Can I buy Cefotaxime + Sulbactam over the counter?
Cefotaxime + Sulbactam is not available for purchase over the counter. A valid prescription from a doctor is required to obtain this medicine.
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