Cefuroxime + Sulbactam

Dosage Forms Available

• Cefuroxime + Sulbactam can be taken orally (tablet) and administered parenterally, either by intravenous (IV) infusion or intramuscular (IM) injection.

Age and Dose Restrictions

• Cefuroxime + Sulbactam is indicated for use in adults and children, with pediatric dosages calculated based on body weight.

Contraindications

• Cefuroxime + Sulbactam is contraindicated in patients with known allergies to cephalosporins, penicillins, or beta-lactams. It should also be used with caution in patients with a history of gastrointestinal diseases, especially colitis.

Other Medications to Avoid

• Cefuroxime + Sulbactam may interact with aminoglycoside antibiotics (gentamicin, tobramycin), oral anticoagulants ( warfarin, apixaban), uricosurics (probenecid) and live bacterial vaccines.

Overdose and Missed Dose

• An overdose of Cefuroxime + Sulbactam may cause neurological excitation, dizziness, confusion, nausea, vomiting, and in severe cases, kidney dysfunction. In case of suspected overdose, seek immediate medical attention.

• If you miss a dose of this medication, take it as soon as you remember. However, if it is close to the time for your next dose, then skip the missed dose. Do not double up on doses to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

• Drinking plenty of water can help manage some gastrointestinal disturbances such as diarrhoea and nausea.

• Resting or lying down can help manage feelings of dizziness.

• Avoid spicy and fatty foods, which can aggravate gastrointestinal disturbances.

Use in Driving and Operating Machinery

• This medication may cause dizziness or fatigue. If you experience these symptoms, avoid driving or operating heavy machinery after taking this medicine.

Use in Pregnancy and Lactation

• Cefuroxime + Sulbactam is not recommended during pregnancy and lactation unless prescribed by your doctor as it falls under pregnancy category B i.e. should be used during pregnancy only if needed and is also excreted in human milk. Consult your doctor before taking this medicine during pregnancy and lactation.

Caution in Other Conditions

• Patients with renal impairment or liver disease should exercise caution when using Cefuroxime + Sulbactam. Dosage adjustment may be necessary.

Special Dietary and Lifestyle Recommendations

• Maintain adequate hydration to support kidney function, as high doses or prolonged use can affect renal function.

• Regularly monitor kidney function if using high doses or if you have pre-existing kidney conditions.