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Ciclosporin

Uses of Ciclosporin

  • Ciclosporin is used to prevent organ rejection in patients who have undergone kidney, liver, or heart transplants. It falls under the category of immunosuppressive medicines.

  • Other uses of Ciclosporin include the management of severe cases of autoimmune disorders such as rheumatoid arthritis, psoriasis, and uveitis. It is also used to manage conditions like nephrotic syndrome and atopic dermatitis and to prevent graft-versus-host disease in bone marrow transplant patients.

Side effects of Ciclosporin

  • High blood pressure

  • Headache

  • Kidney dysfunction

  • Increased blood glucose levels

  • Gastrointestinal disturbances like diarrhoea

How Ciclosporin works

  • Ciclosporin is a potent immunosuppressant.

  • It functions as a calcineurin inhibitor. This means it works by suppressing the body's immune response to keep it from attacking foreign substances, such as transplanted organs.

  • More specifically, Ciclosporin inhibits the activity of T lymphocytes, a type of white blood cell that plays a crucial role in your body's immune response. By decreasing their activity, it helps reduce the risk of organ rejection in transplant patients and manage inflammation in various autoimmune disorders.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Ciclosporin is available for use via the oral route in the form of capsules and solutions.

  • It is also available as a liquid to drink.

Age and Dose Restrictions

  • Ciclosporin is meant for use in adults and children of all ages, with dose adjustments based on the specific condition being treated.

Contraindications

  • Ciclosporin is contraindicated in patients with known hypersensitivity to Ciclosporin or any of its components.

  • It should not be used in patients with uncontrolled hypertension or active infections.

  • Patients with renal or hepatic impairment should not take this medication.

Other Medications to Avoid

  • Ciclosporin can interact with antibiotics (e.g., erythromycin and clarithromycin), antifungals (e.g., ketoconazole and fluconazole), and calcium channel blockers (e.g., diltiazem and verapamil). Other interactions may occur with anticonvulsants (e.g., carbamazepine and phenytoin), statins (e.g., simvastatin, atorvastatin), and nonsteroidal anti-inflammatory medicines (e.g., ibuprofen and naproxen).

Overdose and Missed Dose

  • An overdose of Ciclosporin may lead to symptoms such as kidney problems, high blood pressure, tremors, headaches, nausea, vomiting, and seizures. In case of suspected overdose, consult a doctor immediately.

  • If you forget to take a dose of Ciclosporin, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the doses.

Management of Side Effects

Most side effects of Ciclosporin are temporary and generally harmless. They resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water may help alleviate some side effects like dry mouth and thirst.

  • Taking Ciclosporin with meals can help manage gastrointestinal side effects such as nausea and stomach upset.

Use in Driving and Operating Machinery

  • Ciclosporin may cause dizziness, blurred vision, or other side effects that could affect your ability to drive or operate machinery. Avoid these activities until you know how this medicine affects you.

Use in Pregnancy and Lactation

  • It is advised to consult your doctor before using Ciclosporin during pregnancy or breastfeeding. The potential benefits must be weighed against the potential risks.

Caution in Other Conditions

  • Patients with kidney or liver disease should use Ciclosporin with caution, as it can worsen these conditions.

  • Caution should also be exercised in patients with high blood pressure or infections, as Ciclosporin can affect blood pressure control and immune response.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet to prevent weight gain and to manage side effects such as high blood fat levels.

  • Regular physical activity can help manage high blood pressure, a potential side effect of Ciclosporin.

  • Regular monitoring of blood pressure is recommended.

  • Avoid consumption of grapefruit or grapefruit juice while on Ciclosporin medication.

  • Practice good oral hygiene to avoid gum problems that may be caused by Ciclosporin.

Frequently asked questions

No, Ciclosporin is not a steroid medication. It belongs to a class of medicines known as immunosuppressants.

Certain individuals may experience sleep disturbances while taking Ciclosporin, but this is not a common side effect. If you notice any changes in your sleep pattern, consult your doctor.

Yes, regular monitoring is important while taking Ciclosporin to ensure its effectiveness and to detect any potential side effects or complications. This may include regular blood tests, blood pressure monitoring, and frequent check-ups with your doctor.

The suitability of Ciclosporin for vegetarians or vegans depends on the specific formulation of the medicine. Some types of Ciclosporin may contain ingredients derived from animals. Please check with your pharmacist for more information.

Ciclosporin is usually taken daily as prescribed by the doctor to manage certain conditions. The duration and dosage of the medication depend on the condition being managed.

The onset of action of Ciclosporin can vary depending on the condition it is being used to manage. The full benefits of the medicine may not be evident until several weeks after starting therapy.

The best time to take Ciclosporin is as advised by your doctor. It may be taken with or without food.

Terms & Conditions

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