Cilnidipine + Metoprolol

Dosage Forms Available

• Cilnidipine + Metoprolol is available for oral administration in the form of tablets and capsules.

Age and Dose Restrictions

• This combination medicine is primarily meant for adults. It may be prescribed to adolescents above 18 years under careful medical supervision.

Contraindications

• Cilnidipine + Metoprolol is contraindicated in patients with known hypersensitivity to either component.

• It is also contraindicated in patients with severe bradycardia, sick sinus syndrome, 2nd or 3rd-degree AV block, cardiogenic shock, decompensated heart failure, and severe hepatic impairment.

Other Medications to Avoid

• This combination can interact with CYP3A4 inhibitors and inducers (such as ketoconazole, erythromycin), CYP2D6 inhibitors (such as fluoxetine, paroxetine), other antihypertensives (like losartan, amlodipine), digitalis glycosides (like digoxin), and antiarrhythmics (e.g. amiodarone, disopyramide).

Overdose and Missed Dose

• An overdose can lead to severe hypotension, bradycardia, heart block, shock and cardiac arrest. If you suspect an overdose, seek immediate medical attention.

• If you miss a dose of this medicine, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosage schedule. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of the symptoms, please consult your doctor.

• Drinking plenty of water may help manage some of the side effects like dizziness or fatigue.

• Resting or lying down can help manage dizziness, especially when rising from a sitting or lying position.

Use in Driving and Operating Machinery

• Cilnidipine + Metoprolol may cause dizziness or fatigue, which may affect your ability to drive or operate heavy machinery. Avoid these activities if you experience these side effects after taking this medication.

Use in Pregnancy and Lactation

• This combination should only be used in pregnancy and while breastfeeding if the potential benefits outweigh the possible risks. It is advisable to consult your doctor before taking this medication during these periods.

Caution in Other Conditions

• Caution should be exercised when taking Cilnidipine + Metoprolol in conditions like renal impairment, peripheral vascular disease, metabolic acidosis and myasthenia gravis.

Special Dietary and Lifestyle Recommendations

• Follow a low-salt diet to further manage your blood pressure levels.

• Engage in regular physical activity such as walking or cycling to maintain a healthy weight and control blood pressure.