Cilnidipine + Nebivolol is primarily used to manage essential hypertension in adults. It belongs to the class of medicines called dihydropyridine calcium channel blockers and third-generation beta-blockers.
Dizziness
Headache
Fatigue
Slow heart rate
Swelling in the limbs
Cilnidipine + Nebivolol is an antihypertensive combination.
Cilnidipine, a dihydropyridine calcium channel blocker, works by selectively blocking L-type and N-type calcium channels, which helps relax and widen your blood vessels. This reduces the resistance to blood flow in your peripheral blood vessels and decreases the workload on your heart.
Nebivolol is a third-generation beta-blocker. It works by blocking the action of certain natural chemicals like adrenaline on your heart and blood vessels. This slows down your heart rate and reduces its workload. Moreover, it also helps to widen your blood vessels by stimulating the release of nitric oxide from the endothelium, a layer of cells that line the interior surface of blood vessels.
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Cilnidipine + Nebivolol is available in the form of oral tablets.
Cilnidipine + Nebivolol is intended for use in adults only.
This combination is contraindicated in patients with severe bradycardia (very slow heart rate).
It should not be used by those with heart block greater than first-degree, cardiogenic shock, or decompensated cardiac failure.
Patients with sick sinus syndrome (unless a permanent pacemaker is in place) should avoid this combination.
Severe hepatic impairment (Child-Pugh class C) also serves as a contraindication.
This combination may interact with CYP2D6 inhibitors (such as quinidine, fluoxetine, and paroxetine), CYP3A4 inhibitors (like itraconazole and ritonavir), digitalis glycosides (like digoxin), and other calcium channel blockers (such as verapamil and diltiazem).
An overdose may lead to severe low blood pressure, slow heart rate, or even shock. If you suspect an overdose, it is essential to seek immediate medical attention.
If a dose is missed, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If experiencing dizziness, try lying down until the sensation passes.
For dry mouth, sipping water regularly can help alleviate discomfort.
This combination may cause dizziness or fatigue. If you experience these symptoms, avoid driving or operating heavy machinery until you feel that you can perform these activities safely.
The safety of Cilnidipine + Nebivolol during pregnancy and lactation has not been established. Therefore, it is generally recommended to avoid using this combination during these periods unless deemed necessary by a doctor.
Special caution should be used when administering this combination to patients with bronchospastic diseases, peripheral vascular disease, diabetes, thyroid disorders, and those under anaesthesia.
Those with existing conditions affecting liver function should also use this combination carefully.
Reduce salt intake; high sodium levels can contribute to increased blood pressure.
Regular physical activity such as walking, cycling, or swimming can help lower blood pressure naturally.
Monitor your blood pressure regularly.
Avoid smoking and limit alcohol intake as these can adversely affect blood pressure levels.
Frequently asked questions
No, it is not a steroid. It is a combination that contains two active ingredients: Cilnidipine, a calcium channel blocker, and Nebivolol, a beta-blocker.
It may cause insomnia in some individuals. If you experience difficulty sleeping while taking this combination, consult your doctor for advice.
There is no evidence that it affects fertility. If you have concerns about fertility while taking this combination, it would be best to discuss them with your doctor.
There are no specific dietary restrictions required for patients taking this combination. However, maintaining a balanced diet would assist the overall management of hypertension.
Yes, it is safe to take it daily as prescribed by your doctor. This combination is typically used as a long-term treatment for hypertension.
The active ingredients in Cilnidipine + Nebivolol are synthetically produced in a lab. However, the other ingredients or the capsule shell may contain animal-derived products. Please check the package insert or consult your pharmacist for more information.
This combination can cause dizziness, headache, and fatigue, which might affect your mood or behaviour to some extent. If these persist or worsen, you should consult your doctor.
Cilnidipine + Nebivolol in other salts
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