Citicoline
Uses of Citicoline
The primary use of Citicoline is in the management of various neurological disorders. It belongs to the group of neuroprotective and nootropic medicines.
Citicoline has been found effective in managing cerebrovascular diseases such as acute ischemic stroke, chronic cerebral vascular disorders, cognitive impairment including age-related memory decline, vascular dementia, Alzheimer's disease, Parkinson's disease dementia, traumatic brain injuries, and eye disorders like amblyopia and glaucoma. It is also used to manage Attention deficit hyperactivity disorder (ADHD). Furthermore, research is being conducted to explore its potential benefits in addictive disorders, mood disorders, and other neuropsychiatric conditions.
Side effects of Citicoline
Stomach pain
Nausea
Diarrhoea
Changes in appetite
Headache
How Citicoline works
Citicoline is a neuroprotective agent.
After being taken, it breaks down into two components: choline and cytidine, which pass freely through the blood-brain barrier. Once in the brain, these two components help in the biosynthesis of phosphatidylcholine, a constituent of brain cell membranes. This aids in maintaining their integrity and function. It also boosts brain metabolism by improving glucose and oxygen utilisation, thereby providing energy for brain cells. Citicoline helps maintain levels of essential neurotransmitters which are crucial for sending signals between nerve cells. It also reduces damage caused by harmful chemicals produced during stroke or head injury. Consequently, Citicoline plays a key role in preserving brain health and enhancing cognitive functions.
Certified content
Written By
MD Ayurveda
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Citicoline can be taken orally (tablet or capsule), intravenously or intramuscularly (injection) and ophthalmic solution (eye drops).
Age and Dose Restrictions
Citicoline is meant for both adults and children.
Contraindications
Use of Citicoline is contraindicated in patients who have a known hypersensitivity to Citicoline or any of its ingredients. It should also be used with caution in patients with low blood pressure as it could potentially lower blood pressure further.
Other Medications to Avoid
Citicoline may interact with cholinergic medicines (such as donepezil and rivastigmine), medications that lower blood pressure (like atenolol, and lisinopril), and central nervous system depressants (including diazepam, and lorazepam).
Overdose and Missed Dose
Overdosing on Citicoline can lead to various symptoms such as headache, dizziness, and high blood pressure among others. If you suspect an overdose, it's crucial to contact your doctor immediately.
In case of a missed dose, you should take it as soon as you remember. If it's close to the timing of your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If you experience stomach pain or nausea, try taking Citicoline along with meals.
Staying hydrated can help manage changes in appetite and diarrhoea.
Rest and relaxation techniques may help manage headaches, insomnia, and agitation.
Use in Driving and Operating Machinery
Citicoline may cause dizziness or sleepiness in some individuals. It's best to avoid driving or operating heavy machinery until you know how the medicine affects you.
Use in Pregnancy and Lactation
Consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with renal or hepatic impairment should be cautious when taking Citicoline as dose adjustment may be required.
Patients suffering from low blood pressure should also be cautious as Citicoline can further lower the blood pressure.
Special Dietary and Lifestyle Recommendations
Engaging in cognitive activities such as reading, puzzles, or learning a new skill can support brain function.
Frequently asked questions
Can Citicoline help with memory loss?
Yes, Citicoline can assist with memory loss. It has been shown in several studies to improve memory performance and learning in older individuals with memory complaints, mild cognitive impairment or dementia. It helps slow cognitive decline.
How quickly can I expect Citicoline to start working?
The noticeable effects of Citicoline can be seen within 1-2 weeks for acute conditions like stroke or head injury. For chronic neurodegenerative disorders, benefits accrue over time with prolonged use of at least 3-6 months.
Is Citicoline safe for regular, long-term consumption?
Yes, long-term usage of Citicoline is generally safe. It has an excellent safety record in studies up to 12 months of continuous use. Long-term use should always be under medical supervision.
What is the duration of treatment with Citicoline?
The duration of treatment with Citicoline will depend on the specific condition being managed and the individual patient's response to therapy.
What is the best time to take Citicoline?
The best time to take Citicoline will depend on your specific medication schedule as recommended by your doctor.
Is it safe to take Citicoline daily?
Yes, it is generally safe to take Citicoline daily if prescribed by your doctor. Always adhere to the dosage and duration of treatment recommended by your doctor.
Is Citicoline available over the counter, or do I need a prescription?
Citicoline is usually available as a prescription medicine. Consult your doctor for more information.
Citicoline in other salts
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