Clindamycin + Clotrimazole + Metronidazole

Dosage Forms Available

• Clindamycin + Clotrimazole + Metronidazole is available as vaginal creams, vaginal suppositories/ovules, vaginal tablets, and vaginal soft gelatin capsules intended to be inserted in the vagina.

Age and Dose Restrictions

• This medication is primarily meant for adults.

Contraindications

• This combination is contraindicated in patients with known hypersensitivity to any of the three components, clindamycin, clotrimazole, and metronidazole. It is also not recommended for patients with conditions like porphyria (group of disorders affecting the skin and nervous system), blood dyscrasias (blood related diseases), active neurological disorders and those having a history of hypersensitivity reactions to these medicines.

Other Medications to Avoid

• The combination medicine may interact with anticoagulants (e.g., warfarin), disulfiram (e.g., antabuse), lithium-based medications (e.g., lithobid), and medicines metabolised by CYP450 enzymes (e.g. theophylline, phenytoin), and particularly those metabolised by CYP3A4 (e.g., codeine, diazepam) and metabolised by CYP2C9 (e.g., acetyl salicylic acid and ibuprofen).

Overdose and Missed Dose

• Overdose of this medication can possibly lead to an increase in side effects such as vaginal irritation or dryness, headache, nausea, metallic taste in mouth. If an overdose is suspected, contact your doctor immediately.

• In case you miss a dose, apply or insert it as soon as you remember. However, if it is close to your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water could help reduce the occurrence of headaches and nausea.

• Using a lubricant during intercourse can help alleviate vaginal dryness or burning sensations.

Use in Driving and Operating Machinery

• As this medicine is used for vaginal administration, it is unlikely to affect your ability to drive or operate machinery.

Use in Pregnancy and Lactation

• Clindamycin + Clotrimazole + Metronidazole should be used during pregnancy only if clearly needed and under a doctor's supervision. Breastfeeding is not recommended during the use of this medication as it may cause adverse effects in the infant.

Caution in Other Conditions

• Patients with a history of Clostridium difficile-associated diarrhoea should exercise caution while using this medication.

Special Dietary and Lifestyle Recommendations

• Maintain proper personal hygiene to prevent reinfection or spread of infection.

• Wear breathable, cotton underwear to reduce moisture and prevent fungal infections.

• Avoid sexual intercourse until the infection is completely cured to prevent spread of infection.