Clobetasol Propionate + Gentamicin
Uses of Clobetasol Propionate + Gentamicin
The primary use of Clobetasol Propionate + Gentamicin is to manage inflammatory skin conditions that are also infected with bacteria or at high risk of bacterial infection. This medicine belongs to the group of potent corticosteroids and aminoglycoside antibiotics.
It is also applied to manage specific conditions such as infected eczema, infected contact dermatitis, infected psoriasis, infected seborrheic dermatitis, infected intertrigo, and secondarily infected burns or insect bites.
Side effects of Clobetasol Propionate + Gentamicin
Skin irritation
Burning sensation
Itching at the application site
Dryness of skin
Skin colour changes
How Clobetasol Propionate + Gentamicin works
Clobetasol Propionate + Gentamicin is a combination medicine consisting of a corticosteroid and an antibiotic.
Clobetasol Propionate falls under the category of super-high potency corticosteroids. It works by suppressing the immune response and reducing inflammation in the skin. It achieves this by inhibiting phospholipase A2, which is involved in the release of inflammatory substances like prostaglandins and leukotrienes.
Gentamicin, on the other hand, is an aminoglycoside antibiotic. It combats bacterial infections by binding to the 30S ribosomal subunit in harmful bacteria. This disrupts the bacteria's ability to produce essential proteins, leading to its death.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Clobetasol Propionate + Gentamicin is available for use via the topical route in the form of cream, ointment, or lotion.
Age and Dose Restrictions
This combination of medicines is meant for adults and children above 12 years of age.
Contraindications
Clobetasol Propionate + Gentamicin is contraindicated in patients with known hypersensitivity to either of the components.
It is also contraindicated in patients with viral skin infections, fungal or mycobacterial skin infections, acne rosacea or vulgaris, perioral dermatitis, and perianal or genital pruritus.
Other Medications to Avoid
This combination may interact with oral corticosteroids (such as prednisone), other aminoglycosides (like tobramycin) and other ototoxic or nephrotoxic medications (such as cisplatin or vancomycin).
Overdose and Missed Dose
An overdose of Clobetasol Propionate + Gentamicin is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects.
If you forget to apply this medicine, apply it as soon as you remember. But avoid repeating the dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If a burning sensation persists at the application site, try applying the cream at a different time of day.
Use in Driving and Operating Machinery
Clobetasol Propionate + Gentamicin does not affect your ability to drive or operate heavy machinery.
Use in Pregnancy and Lactation
Consult your doctor before using Clobetasol Propionate + Gentamicin during pregnancy and breastfeeding.
Caution in Other Conditions
Patients with renal impairment should exercise caution when using Clobetasol Propionate + Gentamicin, as gentamicin may accumulate.
Special Dietary and Lifestyle Recommendations
Avoid scratching the affected area to prevent further inflammation or possible bacterial infection.
Wear loose and breathable clothing to allow the skin to heal.
Protect the affected area from excessive heat and cold, as these can worsen the skin condition.
Frequently asked questions
Does Clobetasol Propionate + Gentamicin cause any changes in skin colour?
Yes, one of the rarer side effects of Clobetasol Propionate + Gentamicin can be a change in skin colour, specifically, hypopigmentation. This can result in patches of skin becoming lighter than the surrounding skin.
Is Clobetasol Propionate + Gentamicin a steroid?
Yes, Clobetasol Propionate is a potent corticosteroid. It is combined with Gentamicin, an antibiotic, in medicine to manage certain inflammatory skin conditions.
Can Clobetasol Propionate + Gentamicin affect my mood?
Clobetasol Propionate + Gentamicin is not directly associated with affecting moods. However, underlying skin conditions and their symptoms can potentially impact a person's mood or mental well-being.
Is Clobetasol Propionate + Gentamicin safe for long-term use?
Clobetasol Propionate + Gentamicin is typically not recommended for prolonged use due to the risk of side effects such as skin thinning and adrenal gland problems. It should be used exactly as advised by your doctor.
Does Clobetasol Propionate + Gentamicin cause weight gain?
Weight gain is not a typical side effect of Clobetasol Propionate + Gentamicin. If you notice unusual weight changes while using this medicine, it is advisable to consult your doctor.
Is there any natural alternative to Clobetasol Propionate + Gentamicin?
There are no natural alternatives that can substitute the therapeutic effects of Clobetasol Propionate + Gentamicin. It is crucial to consult your doctor before attempting to replace this medicine with any other substance or remedy.
Can I develop an addiction to Clobetasol Propionate + Gentamicin?
No, Clobetasol Propionate + Gentamicin does not have addictive properties. However, it is important to use this medicine strictly as advised by your doctor to avoid any potential side effects.
Clobetasol Propionate + Gentamicin in other salts
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