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Dabigatran Etexilate

Uses of Dabigatran Etexilate

  • Dabigatran Etexilate is primarily used to decrease the risk of stroke and blood clots in patients with a serious heart rhythm problem called non-valvular atrial fibrillation. It is an anticoagulant medication that helps prevent stroke and systemic embolism in adult patients. 
  • Additionally, it is indicated for managing deep vein thrombosis (DVT) and pulmonary embolism (PE), reducing the risk of recurrence of DVT and PE, and serving as a preventive measure against DVT and PE in adult patients who have undergone hip replacement surgery.

Side effects of Dabigatran Etexilate

  • Bleeding

  • Gastrointestinal problems such as stomach pain and nausea

  • Anemia

  • Allergic reactions

  • Gastritis-like symptoms

How Dabigatran Etexilate works

  • Dabigatran Etexilate is an anticoagulant.

  • It is a prodrug, which means it is inactive when taken but converts into its active form, called dabigatran, inside the body. Dabigatran directly inhibits an enzyme called thrombin. Thrombin plays a crucial role in the formation of blood clots. So, by blocking its action, Dabigatran Etexilate helps to prevent the formation and growth of dangerous blood clots. In addition to stopping clots forming in the blood vessels, it also inhibits free thrombin, fibrin-bound thrombin and thrombin-induced platelet aggregation. This further helps to reduce the risk of problematic clotting events such as strokes or embolisms.

Certified content

Written By

docImg
Dr Vatsalya D GhanekarMedical Content Writer| 5 years

MD Ayurveda

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Dabigatran Etexilate can be taken orally (capsule).

Age and Dose Restrictions

  • Dabigatran Etexilate is meant for adults who are 18 years old and older.

Contraindications

  • Dabigatran Etexilate is contraindicated in patients with a history of serious hypersensitivity reaction to Dabigatran Etexilate. It is not to be used in patients with active pathological bleeding or in those with mechanical prosthetic heart valves.

Other Medications to Avoid

  • Dabigatran Etexilate may interact with P-glycoprotein (P-gp) inducers (such as rifampin), and P-gp inhibitors (like dronedarone or systemic ketoconazole).

Overdose and Missed Dose

  • An overdose of Dabigatran Etexilate may result in symptoms such as unusual bleeding or bruising. If an overdose is suspected, seek immediate medical attention.

  • If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and return to your normal schedule. Avoid doubling the dose.

Management of Side Effects

Most side effects of Dabigatran Etexilate are temporary and resolve once you stop taking the medicine. However, if you experience any severe side effects or worsening symptoms, consult your doctor.

  • To manage upset stomach, take this medication with food.

  • Drinking plenty of water may help reduce the risk of blood clots and aid in mitigating potential adverse effects.

Use in Driving and Operating Machinery

  • Dabigatran Etexilate may sometimes cause dizziness. If you feel dizzy after taking this medication, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Dabigatran Etexilate should only be used during pregnancy if the potential benefit justifies the potential risk to the foetus. Breastfeeding mothers should consult a doctor before using this medicine as it's not recommended during lactation.

Caution in Other Conditions

  • Dabigatran Etexilate should be used with caution in patients with renal impairment as it may impact its effectiveness. The dosage should be adjusted in accordance with the patient's kidney function.

Special Dietary and Lifestyle Recommendations

  • To manage conditions such as atrial fibrillation and deep vein thrombosis for which Dabigatran Etexilate is prescribed, it's crucial to follow a heart-healthy diet low in saturated fat, cholesterol, and sodium.

Frequently asked questions

Dabigatran Etexilate stays in the body for approximately 12 to 17 hours. However, this can vary depending on several factors such as your age, health, and kidney function.

No, you should not stop taking Dabigatran Etexilate abruptly without consulting your doctor as this may increase your risk of developing a blood clot or having a stroke.

Weight gain is not a common side effect of Dabigatran Etexilate. If you notice any unusual changes in your weight while taking this medication, consult your doctor.

Dabigatran Etexilate is generally considered safe for long-term use under the supervision of a doctor. However, continuous monitoring of renal function and regular check-ups are required when using this medication for a prolonged period.

No, Dabigatran Etexilate is not a steroid. It belongs to the class of medicine known as direct thrombin inhibitors.

Dabigatran Etexilate is not associated with affecting sleep. However, if you experience any change in your sleeping pattern after starting this medicine, you should consult your doctor.

Dabigatran Etexilate is not associated with affecting human fertility. Consult your doctor for any concerns.

Terms & Conditions

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