Dalteparin

Dosage forms available

• Dalteparin is available as a sterile solution for subcutaneous injection. It comes in pre-filled syringes and multiple-dose vials, with strengths ranging from 2500 IU/0.2mL to 18,000 IU/0.72mL. This medicine is administered via the subcutaneous route and should not be administered intramuscularly.

Age and dose restrictions

• Dalteparin is intended for use by adults and children above 12 years.

Contraindications

• Dalteparin is contraindicated in patients with known hypersensitivity to dalteparin, heparin, pork products, or any component of the formulation. It should not be used in patients with active major bleeding or in patients with thrombocytopenia associated with a positive in vitro test for antiplatelet antibodies after exposure to dalteparin.

Other medications to avoid with this medicine

• Dalteparin can interact with oral anticoagulants (such as warfarin), platelet inhibitors (like aspirin, NSAIDs, dipyridamole) and thrombolytics (including alteplase, and streptokinase). It may also have significant interactions with other medications affecting hemostasis such as valproic acid, dextran, and hydroxychloroquine. Always consult your doctor before starting any new medications while on Dalteparin therapy.

Overdose and missed dose

• Overdose of Dalteparin can lead to an increased risk of bleeding and possible haemorrhage. If you suspect an overdose, please contact your doctor immediately.
• If you miss a dose of Dalteparin, administer it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on the dose to make up for the missed one.

Management of side effects

Most side effects of Dalteparin are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage hematomas at the injection site, apply a cold compress to reduce swelling.
• For nausea, try taking Dalteparin with food or milk.

Use in driving and operating machinery

• Dalteparin does not usually affect your ability to drive or operate heavy machinery. However, if you feel dizzy or unwell after administration, avoid these activities until you feel better.

Use in pregnancy and lactation

• Dalteparin falls into Pregnancy Category B, so it should be used during pregnancy only if clearly needed. It is not known to be secreted in breast milk in significant amounts. Always consult your doctor before using this medicine during pregnancy or breastfeeding.

Caution in other conditions

• Dalteparin should be used with caution in patients with severe renal or hepatic impairment. Those with an increased risk of haemorrhage, severe uncontrolled hypertension or a history of gastrointestinal ulceration should also exercise caution when using this medicine.

Special dietary and lifestyle recommendation

• Maintain a diet low in Vitamin K, as it can interfere with the effectiveness of anticoagulants like Dalteparin.
• Avoid activities with a high risk of injury to prevent possible bleeding episodes due to anticoagulant therapy.
• Regular monitoring of your blood health will ensure that the medication is working effectively and safely.