Danazol
Uses of Danazol
The primary use of Danazol is in the management of conditions such as endometriosis, fibrocystic breast disease, hereditary angioedema and menorrhagia. It belongs to the group of synthetic steroid medications.
It operates by suppressing ovarian estrogen production, preventing endometrial tissue proliferation in endometriosis, reducing breast nodularity and discomfort in fibrocystic breast disease, and increasing C1 esterase inhibitor levels in hereditary angioedema.
Side effects of Danazol
Weight gain
Acne
Decreased breast size
Deepening of the voice
Oily skin
How Danazol works
Danazol is a synthetic steroid medication.
It has multiple effects on hormones in the body. It hinders the release of follicle stimulating hormone (FSH) and luteinising hormone (LH) from the pituitary gland. These two hormones are essential for the normal menstrual cycle and ovulation. Danazol also directly impedes the production of steroids in the ovaries and endometrial tissue, reducing the production of oestrogen and progestin - female hormones that stimulate the growth of endometrial tissue. Additionally, it enhances the levels of free testosterone, a male hormone, and attaches itself to androgen, progesterone, and glucocorticoid receptors. All these actions together create an environment in the body that has low levels of female hormones (oestrogens) and slightly increased levels of male hormones (androgens). This helps control conditions like endometriosis, fibrocystic breast disease, menorrhagia, and hereditary angioedema.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Danazol can be taken orally (capsule).
Age and Dose Restrictions
Danazol is meant for use in adults and children above 12 years of age.
Contraindications
This medicine is contraindicated in patients with active liver disease, porphyria, undiagnosed vaginal bleeding, androgen-dependent tumour and hypersensitivity to Danazol.
Other Medications to Avoid
Danazol can interact with anticoagulants (such as warfarin), antidiabetic medicines (like insulin and metformin), immunosuppressants (such as cyclosporine and tacrolimus), and cholesterol-lowering agents (statins like atorvastatin, rosuvastatin).
Overdose and Missed Dose
An overdose of Danazol may cause symptoms like weight increase, acne or menstrual irregularities. If you have taken more than the prescribed dose, inform your doctor immediately.
If you forget to take a dose of Danazol, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed dose. Do not double the dose to compensate for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage some side effects, such as acne.
If you experience weight gain, try having smaller meals.
Taking the medication at night may help manage any feelings of nausea or upset stomach.
Use in Driving and Operating Machinery
Danazol may cause dizziness in some patients. If you experience this side effect, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
Danazol is not recommended for use during pregnancy or breastfeeding. It is advised to consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with heart disease, liver disorders, kidney disease, and diabetes should exercise caution when taking Danazol. Always consult your doctor before starting this medication.
Special Dietary and Lifestyle Recommendations
Regular self-examination of breasts can help detect any changes at an early stage if you are using Danazol for fibrocystic breast disorder.
Frequently asked questions
Is Danazol a steroid?
Yes, Danazol is a synthetic steroid that is derived from testosterone. It modulates the action of certain female hormones in the body.
Does taking Danazol have any effect on sleep?
There is no known impact of Danazol on sleep. However, different individuals may experience different side effects, hence it is advisable to consult your doctor if you notice any unusual changes in sleep patterns.
Will taking Danazol affect fertility?
Danazol is often used to manage endometriosis, a condition that can cause infertility. By managing this condition, Danazol could indirectly help improve fertility. However, it is not a fertility medicine and should not be used as one.
Is it safe to take Danazol daily?
Danazol should be taken exactly as prescribed by your doctor. The daily dosage varies based on the medical condition being managed.
How much time does Danazol take to work?
The onset of action of Danazol is variable and depends on the condition being managed and other individual factors. Always follow your doctor's instructions regarding dosage and duration.
What is the best time to take Danazol?
The best time to take Danazol would be as recommended by your doctor, based on your medical condition and overall health.
Can Danazol cause weight gain?
One of the common side effects of Danazol is weight gain. However, not everyone taking this medicine will experience this side effect. If you notice any unusual weight changes while taking this medicine, consult your doctor.
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