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Desloratadine

Uses of Desloratadine

  • The primary use of Desloratadine is for managing allergic conditions such as allergic rhinitis (also known as hay fever) and urticaria (hives). It belongs to the class of second-generation non-sedating antihistamines.

  • This medication is also used for perennial allergic rhinitis, which is a year-round allergy caused by indoor allergens like dust mites, mould, and pet dander. It is also indicated for chronic idiopathic urticaria, which refers to itching and hives with an unknown cause that lasts over six weeks.

Side effects of Desloratadine

  • Sore throat

  • Dry mouth

  • Fatigue

  • Sleepiness

  • Headache

How Desloratadine works

  • Desloratadine is a second-generation, non-sedating antihistamine.

  • It works by selectively binding to histamine H1 receptors, which are proteins on the surface of cells. This blocks histamine, a chemical produced by the body during an allergic reaction, from attaching to these receptors and causing allergy symptoms.

  • Additionally, this medicine inhibits the release of pro-inflammatory cytokines like interleukins and tumour necrosis factor. These substances are produced by the immune system, causing inflammation and worsening allergy symptoms. By inhibiting these substances, Desloratadine reduces inflammation, and thus, the symptoms of allergy.

Certified content

Written By

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Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Desloratadine is available for oral administration in various forms such as tablets, orally disintegrating tablets, and an oral solution.

Age and Dose Restrictions

  • Desloratadine is meant for adults and children above 6 months of age.

  • As always, you should consult your doctor for the correct dosage and follow their prescribed dose.

Contraindications

  • Desloratadine is contraindicated in patients with known hypersensitivity to Desloratadine or Loratadine.

Other Medications to Avoid

  • Desloratadine can interact with CYP3A4 inhibitors (erythromycin, ketoconazole), CYP2D6 inhibitors (fluoxetine, bupropion), and H2 blockers (cimetidine).

Overdose and Missed Dose

  • If you accidentally take more than the prescribed dose of Desloratadine, seek immediate medical attention. Overdose may result in increased drowsiness.

  • If you forget to take a dose of this medication, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one. Do not double the dose to make up for a missed one.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage the side effects of dry mouth, stay hydrated by drinking plenty of water regularly.

  • If sleepiness occurs, taking the dose in the evening may help.

Use in Driving and Operating Machinery

  • Desloratadine does not generally affect your ability to drive or to operate heavy machinery. However, some people experience drowsiness, which may affect their ability to drive or use machines. In such cases avoid driving or operating heavy maghinery.

Use in Pregnancy and Lactation

  • Desloratadine should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. This will be advised by your doctor.

  • This medicine is passed through breast milk, so it should not be used during breastfeeding. Always consult your doctor before using this medicine in pregnancy and breastfeeding.

Caution in Other Conditions

  • Patients with kidney disease should exercise caution when taking this medicine, as dose adjustment may be needed.

  • Patients with liver disease should also exercise caution when taking this medicine, as a reduced dose is recommended.

Special Dietary and Lifestyle Recommendations

  • Try to avoid allergens that trigger your allergic rhinitis or hives. These can include pollen, dust mites, mould, and pet dander for allergic rhinitis and certain foods like nuts, shellfish, or eggs for hives.

  • Maintain a clean environment at home to reduce exposure to allergens.

  • For individuals with allergies, wearing sunglasses and a hat outdoors can help reduce symptoms.

  • Showering before bed can remove allergens from hair and skin and help ensure a good night's sleep.

  • If you have indoor allergies, consider investing in an air purifier to reduce allergens at home.

Frequently asked questions

No, Desloratadine is not a steroid. It is a second-generation antihistamine which is used to manage allergic conditions.

Unlike some other antihistamines, Desloratadine does not cause drowsiness as it does not significantly enter the brain from the blood. Therefore, it should not affect sleep.

There is no reported evidence or data that suggests Desloratadine affects fertility. However, you should always consult your doctor for any concerns about your health.

There are no specific diet restrictions while taking Desloratadine, but it is recommended to maintain a healthy lifestyle and balanced diet during any medication course.

Yes, it is safe to take Desloratadine daily as per the prescribed dosage by your doctor. It is considered safe for long-term use due to its favourable safety profile.

Desloratadine typically begins to work within 1-3 hours after taking the medicine, with maximum symptom relief occurring after a few days of regular use.

Desloratadine can generally be taken at any time of the day. It is best to check with your doctor for the optimum time to obtain the maximum benefit of the medication.

Terms & Conditions


Available medicines for DESLORATADINE
Dazit 10 Tablet 15
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D Lorinol Tablet 15
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Dezlorid Tablet 10
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Dezlorid 10 Tablet 10
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Alides Tablet 10
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D Lorinol Tablet 10
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