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Diazepam + Imipramine

Uses of Diazepam + Imipramine

  • The primary use of Diazepam + Imipramine is in managing depression and severe anxiety disorders. It belongs to the group of benzodiazepines and tricyclic antidepressants.

Side effects of Diazepam + Imipramine

  • Drowsiness

  • Dizziness

  • Dry mouth

  • Constipation

  • Difficulty urinating

How Diazepam + Imipramine works

  • Imipramine, the antidepressant part of the combination, belongs to the class of tricyclic antidepressants. It increases the levels of serotonin and norepinephrine in your brain. These neurotransmitters are chemicals that help control feelings and moods. By preventing these neurotransmitters from being reabsorbed back into the nerve cells, Imipramine helps prolong their mood-lightening effect.

  • Diazepam, the anxiolytic part, belongs to the class of benzodiazepines that enhance the action of GABA, a soothing neurotransmitter in your brain. This causes sedation, lowers anxiety, relaxes muscles and has an anticonvulsant effect.

  • Together, these two components help manage symptoms of depression and associated anxiety. However, it may take a few weeks for the full effects to be noticeable.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Diazepam + Imipramine can be taken orally (tablet).

Age and Dose Restrictions

  • This combination is generally prescribed for adults.

Contraindications

  • Diazepam + Imipramine is contraindicated in patients with known hypersensitivity to either Diazepam or Imipramine. It is also contraindicated in patients with acute narrow-angle glaucoma, severe liver disease, a certain muscle disease (myasthenia gravis), lung/breathing problems (such as COPD and sleep apnoea syndrome), and certain blood disorders (porphyria).

Other Medications to Avoid

  • Diazepam + Imipramine can interact with other antidepressants (such as phenelzine and citalopram), antihistamines (such as diphenhydramine and cetirizine), antiseizure medicines (like phenytoin), acid-reducing agents (like cimetidine and omeprazole), antifungal medications (like ketoconazole), and blood thinners (like warfarin and aspirin).

Overdose and Missed Dose

  • An overdose of Diazepam + Imipramine may cause extreme drowsiness, confusion, muscle weakness, fainting, or coma. In case of suspected overdose, seek immediate medical assistance.

  • In case of a missed dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Never double up to make up for a missed dose.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water may help to reduce the side effect of dry mouth associated with this medication.

  • If you experience constipation, increase your intake of fibre and stay well hydrated.

  • Try resting and avoiding sudden movements if you experience dizziness.

  • A regular sleep pattern may help if you are experiencing insomnia.

Use in Driving and Operating Machinery

  • Diazepam + Imipramine may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid such activities until you know how the medicine affects you.

Use in Pregnancy and Lactation

  • Diazepam + Imipramine should be used during pregnancy and breastfeeding only if the potential benefit justifies the potential risk to the foetus or infant. Always consult your doctor before using this medicine while pregnant or breastfeeding.

Caution in Other Conditions

  • Caution should be exercised when administering Diazepam + Imipramine in patients with kidney disease, liver disease, heart conditions, glaucoma, urinary retention, or a history of medicine abuse.

  • It should also be used with caution in people with a history of seizures, bipolar disorder, or suicidal tendencies.

Special Dietary and Lifestyle Recommendations

  • Limit caffeine and sugar intake as they can worsen anxiety symptoms.

Frequently asked questions

Long-term use of Diazepam + Imipramine may lead to dependency and withdrawal symptoms upon discontinuation. Therefore, it should only be used under the supervision of your doctor.

Diazepam, a component of Diazepam + Imipramine, can lead to physical and psychological dependency, especially with long-term use or high doses.

Abrupt discontinuation of Diazepam + Imipramine can lead to withdrawal symptoms such as restlessness, irritability, and sleep disturbances.

Yes, Diazepam + Imipramine can cause side effects like drowsiness and confusion, which may impair your ability to focus or concentrate.

Yes, Diazepam + Imipramine helps in improving mood by increasing the levels of neurotransmitters serotonin and norepinephrine in the brain, which regulate emotions.

There are no known significant effects of Diazepam + Imipramine on menstruation. However, if you notice any unusual changes, it is recommended to consult your doctor.

Yes, Diazepam + Imipramine can potentially affect your sleep. One of its active ingredients, diazepam, can cause drowsiness and fatigue, which may influence your sleep patterns. If you find that this medicine is significantly affecting your sleep, you should consult your doctor.

Terms & Conditions


Available medicines for DIAZEPAM + IMIPRAMINE
Depsin Plus 25/2 MG Tablet 10
Depsin Plus 25/2 MG Tablet 10
Synokem Pharmaceuticals Ltd
Pack of 10 Units
₹10.25
MRP ₹12.50
18.00% OFF
Depsol Forte 25/5 MG Tablet 10
Depsol Forte 25/5 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹13.12
MRP ₹16.00
18.00% OFF
Depsonil Dz 25/2 MG Tablet 10
Depsonil Dz 25/2 MG Tablet 10
Abbott Healthcare Pvt. Ltd
Pack of 10 Units
₹14.76
MRP ₹18.00
18.00% OFF
Depranil Plus 25/5 MG Tablet 10
Depranil Plus 25/5 MG Tablet 10
La Pharmaceuticals
Pack of 10 Units
₹12.38
MRP ₹15.10
18.00% OFF
Depik Forte 25/5 MG Tablet 10
Depik Forte 25/5 MG Tablet 10
Aarpik Remedies Pvt.ltd.
Pack of 10 Units
₹9.84
MRP ₹12.00
18.00% OFF
Anxidep 25/2.5 MG Tablet 10
Anxidep 25/2.5 MG Tablet 10
Mayflower India
Pack of 10 Units
₹59.04
MRP ₹72.00
18.00% OFF
Depsol Plus 25/2 MG Tablet 10
Depsol Plus 25/2 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹11.48
MRP ₹14.00
18.00% OFF
Depik Plus 25/2 MG Tablet 10
Depik Plus 25/2 MG Tablet 10
Aarpik Remedies Pvt.ltd.
Pack of 10 Units
₹10.62
MRP ₹12.95
18.00% OFF

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