Diazepam + Propranolol

Dosage Forms Available

• Diazepam + Propranolol can be taken orally (tablet).

Age and Dose Restrictions

• This combination is intended for use by adults and is not recommended for children.

Contraindications

• Contraindicated in patients with hypersensitivity to either component of the medicine.

• Contraindicated in myasthenia gravis, severe respiratory insufficiency, sleep apnoea syndrome, severe hepatic impairment, acute narrow-angle glaucoma, cardiogenic shock, sinus bradycardia and heart block, bronchial asthma and chronic obstructive pulmonary disease, pheochromocytoma, and porphyrias.

Other Medications to Avoid

• This combination may interact with alcohol, opioids (such as morphine and codeine), barbiturates (including phenobarbital and butalbital), other sedatives (like zolpidem and eszopiclone), oral antidiabetic medications (including metformin and glibenclamide), NSAIDs (such as ibuprofen and aspirin), antiarrhythmics (like amiodarone), calcium channel blockers (including amlodipine), and medicines metabolised by CYP2D6 and CYP1A2 enzymes (such as fluoxetine).

Overdose and Missed Dose

• An overdose may result in profound drowsiness, respiratory depression, confusion, slow reflexes, hypotension, bradycardia, or coma. Immediate medical intervention is crucial.

• If you miss a dose of this combination, it is advisable to take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If experiencing dry mouth or constipation, increasing water intake may help alleviate these discomforts.

• In case of dizziness or lightheadedness from low blood pressure, lying down until the feeling passes can be beneficial.

Use in Driving and Operating Machinery

• Diazepam + Propranolol may impair your ability to drive or operate heavy machinery due to its potential sedative effects. It is advisable to avoid engaging in activities requiring mental alertness until you know how this medicine affects you.

Use in Pregnancy and Lactation

• The use of Diazepam + Propranolol during pregnancy and lactation is advised only under the direct supervision of a doctor.

Caution in Other Conditions

• Caution is advised when using this combination in patients with renal or hepatic conditions due to potential alterations in medicinal metabolism and excretion that could enhance adverse effects or reduce medicine-clearance.

Special Dietary and Lifestyle Recommendations

• To manage anxiety effectively while using this combination, incorporating relaxation techniques such as deep breathing exercises, meditation, or yoga can be beneficial.

• Avoiding caffeine and stimulants, which can exacerbate anxiety symptoms, is recommended.

• Keeping a diary to track episodes of anxiety could help identify triggers and improve coping mechanisms.