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Difluprednate

Uses of Difluprednate

  • Difluprednate is primarily used for the management of postoperative inflammation and pain following ocular surgery and it belongs to the class of topical corticosteroids.

  • It is also indicated for managing ocular inflammatory conditions such as anterior uveitis, panuveitis, and endogenous uveitis. Additionally, it is used off-label for managing ocular surface and anterior segment inflammatory disorders like allergic conjunctivitis, episcleritis, scleritis, and keratitis.

Side effects of Difluprednate

  • Swelling of the cornea

  • Eye pain

  • Sensitivity to light

  • Redness of the eye's surface

  • Cloudiness or haze in the front part of the eye

How Difluprednate works

  • Difluprednate is a corticosteroid.

  • It works by binding to specific glucocorticoid receptors inside cells. This binding forms a complex that moves into the cell's nucleus, where it influences the activity of certain genes, resulting in less inflammation. Specifically, Difluprednate prevents an enzyme called phospholipase A2 from working effectively, leading to reduced production of chemicals that cause inflammation, such as prostaglandins and leukotrienes. Additionally, it stabilises cell membranes, lessens the leakiness of tiny blood vessels (capillaries), and suppresses immune responses. All these actions further help to reduce inflammation and manage conditions related to eye inflammation.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Divya Chauhan
Dr. Divya Chauhan Medical Writer & Reviewer| 6 years

BAMS, APG, PG

Expert Advice

Dosage Forms Available

  • Difluprednate can be applied topically (ophthalmic emulsion).

Age and Dose Restrictions

  • This medicine is primarily prescribed for adults.

Contraindications

  • Difluprednate is contraindicated in individuals with most active viral diseases of the cornea and conjunctiva, such as epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and mycobacterial or fungal infections of the eye. Patients with known hypersensitivity to Difluprednate or any other components of the formulation should avoid using this medication.

Other Medications to Avoid

  • Difluprednate may interact with other corticosteroids (e.g., prednisolone, hydrocortisone), antiglaucoma medications (e.g., timolol, brimonidine) and nonsteroidal anti-inflammatory medicines (NSAIDs) (e.g., ibuprofen, naproxen).

Overdose and Missed Dose

  • In case you happen to put a few extra drops of this medicine in your eye, do not panic. Rinse your eyes with clean water at room temperature. If any symptoms persist or worsen, inform your doctor.

  • If you miss a dose, administer it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage dryness or irritation in the eyes, apply a warm compress and stay away from smoke, dust, and other potential irritants.

  • Taking rest and avoiding activities that strain the eyes may help manage eye pain or discomfort.

Use in Driving and Operating Machinery

  • Difluprednate can cause blurred vision temporarily. If you experience this side effect, avoid driving or operating heavy machinery until your vision clears.

Use in Pregnancy and Lactation

  • Difluprednate should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Consult your doctor before using this medicine while breastfeeding.

Caution in Other Conditions

  • Regular monitoring of intraocular pressure is necessary, if Difluprednate is used for 10 days or longer, due to the risk of glaucoma from prolonged use.

  • Patients with a history of ocular herpes simplex should exercise caution when using Difluprednate as it may prolong and exacerbate the severity of many viral eye infections.

Special Dietary and Lifestyle Recommendations

  • Wearing protective sunglasses can aid in reducing discomfort caused by light sensitivity.

  • Follow the 20-20-20 rule by taking a break every 20 minutes to look at something 20 feet away for 20 seconds, especially if you use screens frequently.

  • Do not wear contact lenses while using Difluprednate unless your doctor advises otherwise.

Frequently asked questions

Yes, Difluprednate is a steroid. It is classified as a topical corticosteroid medication which is primarily used in ophthalmology.

There is no indication that Difluprednate affects sleep. However, if you experience sleep disturbances after starting this medication, consult your doctor.

Difluprednate is not known to affect fertility. As always, it is important to discuss any concerns about fertility with your doctor.

The use of Difluprednate should be strictly as directed by your doctor. The frequency and duration of its use will depend on your condition and its severity.

The time for Difluprednate to take effect can vary depending on the condition it is being used to manage. Always consult your doctor for more detailed information.

The best time to apply Difluprednate should be as advised by your doctor based on your specific condition and treatment response.

Difluprednate is a prescription medicine and is not usually available over the counter.

Terms & Conditions


Available medicines for DIFLUPREDNATE
Diflusenz 0.05 % Eye Drops 5 ML
Diflusenz 0.05 % Eye Drops 5 ML
Senses Pharmaceuticals Ltd
Pack of 5 ML
₹70.28
MRP ₹85.71
18.00% OFF
Flupred 0.05 % Eye Drops 5 ML
Flupred 0.05 % Eye Drops 5 ML
Sun Pharma Laboratories Ltd.
Pack of 5 ML
₹116.85
MRP ₹142.50
18.00% OFF
Diflusol Eye Drops 5 ML
Diflusol Eye Drops 5 ML
Phoenix Lifesciences
Pack of 5 ML
₹96.76
MRP ₹118.00
18.00% OFF
Optipred 0.05 % Eye Drops 5 ML
Optipred 0.05 % Eye Drops 5 ML
Calix Life Sciences Pvt Ltd
Pack of 5 ML
₹81.18
MRP ₹99.00
18.00% OFF
Baklot Eye Drops 5 ML
Baklot Eye Drops 5 ML
Akumentis Healthcare Ltd
Pack of 5 ML
₹89.38
MRP ₹109.00
18.00% OFF
Diflup Eye Drops 5 ML
Diflup Eye Drops 5 ML
Ordain Healthcare Pvt. Ltd
Pack of 5 ML
₹73.80
MRP ₹90.00
18.00% OFF
Diflutos Eye Drops 5 ML
Diflutos Eye Drops 5 ML
Chemo Health Care Pvt Ltd
Pack of 5 ML
₹84.33
MRP ₹169.00
50.10% OFF
Dfrot 0.05 % Eye Drops 5 ML
Dfrot 0.05 % Eye Drops 5 ML
Pharmtak
Pack of 5 ML
₹82.00
MRP ₹100.00
18.00% OFF

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