The primary use of Diloxanide is in managing intestinal amoebiasis, a condition caused by parasitic infections and belongs to antiprotozoal agents.
It is also used to manage other parasitic infections in the gastrointestinal tract like giardiasis.
Gastrointestinal disturbances: Nausea, vomiting, and diarrhoea
Abdominal pain
Loss of appetite
Headache and dizziness
Allergic reactions: rash, itching, or hives
Diloxanide is an antiprotozoal agent.
It works by hindering the synthesis of proteins in the parasites that cause the infection. This disrupts their growth and survival, preventing them from multiplying. Specifically, Diloxanide acts within the intestinal lumen, which means it targets the parasites located in the intestines without significantly entering the bloodstream. This localised action helps to reduce systemic side effects.
Doctor of Medicine
BMS, FMC, MD Resident
Diloxanide is available in tablet form for oral administration.
Diloxanide is suitable for both adults and children. The specific age range for children's use is guided by body weight.
This medicine is contraindicated in patients with known hypersensitivity to Diloxanide or any of its components.
It is also contraindicated in individuals with a history of severe liver disease.
This medicine may interact with other antiprotozoals (eg., metronidazole), immunosuppressants (eg., cyclosporine), and certain antibiotics (eg., tetracycline and erythromycin).
An overdose of Diloxanide may lead to increased side effects such as nausea, abdominal discomfort, or severe allergic reactions. If you suspect an overdose, it is important to seek immediate medical attention.
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Avoid repeating the doses.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage nausea, try taking Diloxanide with food or after a light meal.
If experiencing mild abdominal discomfort, ensure adequate hydration by drinking plenty of water.
Diloxanide may cause dizziness or headaches in some individuals. It is advisable to avoid driving or operating heavy machinery if you experience these side effects.
This medicine is not recommended during pregnancy and breastfeeding unless specifically advised by a healthcare professional due to the lack of specific data. Consult a doctor before taking this medicine during these periods.
Patients with pre-existing liver conditions should use Diloxanide with caution. Regular monitoring of liver function may be necessary during treatment.
Individuals with severe allergic reactions to similar medications should also exercise caution when using Diloxanide.
Maintain good personal hygiene practices such as washing hands thoroughly before eating and after using the restroom to prevent the spread of parasitic infections.
Ensure safe drinking water by boiling or using certified clean water sources; this helps prevent amoebiasis and other water-borne illnesses.
Consider using purified or bottled water when travelling to areas where water contamination is common.
Avoid raw or undercooked meat and vegetables that have not been properly cleaned, especially when travelling.
Engage in regular physical activity to boost overall health and immune function, which can help the body resist infections more effectively.
Frequently asked questions