Domperidone + Paracetamol/acetaminophen

Dosage Forms Available

• Domperidone + Paracetamol/Acetaminophen is available for use via oral route in the form of tablets.

Age and Dose Restrictions

• This medicine is intended for adults and children above 12 years of age.

Contraindications

• This combination is contraindicated in patients with known hypersensitivity to either ingredient.

• It is not to be used by patients suffering from gastrointestinal haemorrhage, obstruction or perforation, hepatic impairment, breast cancer or other prolactin-releasing tumours, as well as those with QT prolongation or ventricular arrhythmia.

Other Medications to Avoid

• Domperidone + Paracetamol/Acetaminophen may interact with CYP3A4 inhibitors (such as azole antifungals, macrolide antibiotics, HIV protease inhibitors and nefazodone) and anticoagulants (like warfarin).

Overdose and Missed Dose

• In case of overdose of Domperidone + Paracetamol/Acetaminophen, symptoms may include drowsiness, disorientation and extrapyramidal reactions. Seek immediate medical attention.

• If a dose is missed, take it as soon as possible. However, if it is almost time for the next dose, skip the missed one. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless, and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water can help manage dry mouth.

• Dietary modifications can help manage diarrhoea.

Use in Driving and Operating Machinery

• This combination of medicines can cause drowsiness. It is advisable to avoid driving or operating heavy machinery if you feel drowsy or dizzy after taking this medicine.

Use in Pregnancy and Lactation

• While Paracetamol is considered safe during pregnancy when used as directed, Domperidone is classified as pregnancy category C.

• Lactating women should also exercise caution, as Domperidone can increase milk production.

Caution in Other Conditions

• Patients with hepatic or renal impairment should exercise caution when taking Domperidone + Paracetamol/Acetaminophen.

Special Dietary and Lifestyle Recommendations

• Practice stress reduction techniques such as meditation or yoga.

• Regular gentle exercises like walking or cycling can help maintain overall health and well-being.