Domperidone + Ranitidine

Dosage Forms Available

• Domperidone + Ranitidine can be taken orally (tablet).

Age and Dose Restrictions

• Domperidone and Ranitidine are generally prescribed for adults and adolescents aged 12 and older, with guidance from a doctor.

Contraindications

• Patients with hypersensitivity to either domperidone or ranitidine should not take this medicine. Individuals with a prolactin-releasing pituitary tumour (prolactinoma), moderate to severe liver impairment, or conditions where increased gastrointestinal motility could be harmful (such as gastrointestinal haemorrhage, mechanical obstruction or perforation) are advised against the use of Domperidone + Ranitidine. Those with QTc prolongation or a history of ventricular arrhythmia should also avoid this medicine.

Other Medications to Avoid

• Domperidone + Ranitidine may interact with antifungal medication (e.g., ketoconazole), which can increase the levels of domperidone and increase the risk of QT prolongation.

Overdose and Missed Dose

• An overdose of Domperidone and Ranitidine can cause symptoms like drowsiness, confusion, involuntary muscle movements (extrapyramidal reactions), and irregular heart rhythms (QT prolongation). Seek immediate medical attention if you experience any of these symptoms.

• If a dose is missed, take it as soon as you remember. However, if it is near the timing for the next dose, skip the missed dose and take the next one at the regular time.

Management of Side Effects

Most side effects of Domperidone + Ranitidine are temporary and generally harmless and resolve upon discontinuation of the medication. However, if you experience any severe side effects or worsening symptoms, immediately contact your doctor.

• To manage side effects like dry mouth, stay hydrated by drinking plenty of water throughout the day.

• If you experience dizziness after taking this medicine, avoid sudden movements and rest until the feeling subsides.

Use in Driving and Operating Machinery

• Domperidone + Ranitidine may cause drowsiness or dizziness in some individuals. If you experience these side effects, avoid driving or operating heavy machinery until the symptoms subside.

Use in Pregnancy and Lactation

• The use of Domperidone + Ranitidine during pregnancy or lactation should only be considered if the benefits outweigh the risks. Always consult your doctor if you are pregnant or breastfeeding before taking this medication.

Caution in Other Conditions

• Patients with QT prolongation or a history of ventricular arrhythmia should exercise caution when taking Domperidone + Ranitidine.

• Individuals with liver impairments should also use this medication cautiously due to the potential increased risk of side effects.

Special Dietary and Lifestyle Recommendations

• To manage gastrointestinal conditions like GERD, peptic ulcers, and dyspepsia, maintain a balanced diet that is low in fatty, spicy or acidic foods, which can irritate the stomach lining.

• Regular stress management techniques such as yoga, mindfulness or meditation can also be beneficial in managing these conditions.