Dutasteride
Uses of Dutasteride
Dutasteride is primarily used for managing moderate to severe symptomatic Benign Prostatic Hyperplasia (BPH) in men with an enlarged prostate gland. It belongs to the class of medications known as 5-alpha reductase inhibitors.
In combination with other medications like tamsulosin or doxazosin, Dutasteride can also provide better symptom control for BPH.
Side effects of Dutasteride
Decreased sexual drive
Impotency
Sexual disorders
Breast tenderness and swelling
Testicular pain or swelling
How Dutasteride works
Dutasteride belongs to the category of medicines known as 5-alpha reductase inhibitors.
It works by inhibiting the activity of an enzyme, 5-alpha reductase, which is responsible for the conversion of testosterone into dihydrotestosterone (DHT).
Normally, DHT is a key hormone that causes growth in prostate tissue. When Dutasteride stops this conversion, it leads to reduced levels of DHT.
As a result, the size of the enlarged prostate gland decreases, which alleviates symptoms such as difficulty in urination and frequent need to urinate.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage forms available
Dutasteride is available for use in the form of soft gelatin capsules intended to be taken orally.
Age and dose restrictions
This medicine is meant specifically for adult men and is not recommended for use in children or women.
Contraindications
Dutasteride is contraindicated in patients with known hypersensitivity to it or any of the ingredients in it. Patients with severe liver disease should not take this medicine.
Avoid using Dutasteride if you are allergic to it or similar category medications known as 5-alpha reductase inhibitors.
Other medications to avoid
Dutasteride can interact with antiviral medicines (e.g., ritonavir), antifungal medicines (e.g., itraconazole, fluconazole, and ketoconazole), antibacterial medicines (e.g., ciprofloxacin), calcium channel blockers (e.g., verapamil and diltiazem), and acid suppressants (e.g., cimetidine).
Overdose and missed dose
An overdose of Dutasteride is unlikely to pose a significant threat, but if there are symptoms like facial swelling or skin rash, contact your doctor immediately.
If you miss a dose, take it as soon as you remember, provided it's not too close to the time for your next dose. In that case, skip the missed dose and continue with your regular schedule.
Management of side effects
Most side effects are temporary and generally harmless, resolving soon after discontinuing this medicine. However, if you experience any severe side effects or worsening of symptoms, please consult your doctor.
If you feel dizzy or faint, lie down and raise your legs.
Drinking plenty of water can help manage side effects like feeling nauseous.
Check with your doctor if there's a better time of day to take this medicine to reduce side effects.
Use in driving and operating machinery
Dutasteride does not generally affect your ability to drive or operate heavy machinery. However, if you feel drowsy after taking this medicine, it is advisable not to drive or operate machinery.
Use in pregnancy and lactation
This medication is intended for use in adult men, and is therefore not applicable for pregnant or lactating women.
Caution in other conditions
If you have liver disease, use Dutasteride with caution as it could increase your risk of side effects.
Special dietary and lifestyle recommendations
Regular check-ups with your doctor can help monitor the size of your prostate and assess the progress of treatment.
Limiting alcoholic drinks and caffeine, especially at night, can reduce the frequency of urination.
Training your bladder by timing your toilet visits can also help manage symptoms of an enlarged prostate.
Frequently asked questions
How does Dutasteride work?
Dutasteride belongs to the class of medicines known as 5-alpha reductase inhibitors. It blocks the conversion of testosterone to dihydrotestosterone (DHT), a hormone that contributes to prostate growth.
How long does Dutasteride take to work?
Dutasteride doesn't work immediately. It can take up to 3 to 6 months to notice any improvement in your symptoms.
Is Dutasteride effective in reducing prostate size?
Yes, by blocking the conversion of testosterone to DHT, Dutasteride can help shrink the enlarged prostate and alleviate associated urinary symptoms.
Can one stop taking Dutasteride if symptoms improve?
It is important to continue taking Dutasteride as prescribed by your doctor, even if you feel better. Discontinuing the medicine abruptly might lead to a relapse of symptoms.
Can Dutasteride cause depression?
Depression is not a common side effect of Dutasteride. However, if you feel depressed while taking this medicine, speak to your doctor.
Is Dutasteride safe for long-term use?
Dutasteride is usually safe for long-term use under the supervision of a doctor. However, it's important to have regular check-ups to monitor its effects.
Can I donate blood while taking Dutasteride?
No, you should avoid donating blood while taking Dutasteride and for at least 6 months after you stop taking it.
Dutasteride in other salts
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