Enzalutamide
Uses of Enzalutamide
The primary use of Enzalutamide is for managing metastatic castration-resistant prostate cancer (mCRPC), a type of prostate cancer that continues to grow despite low levels of testosterone in the body. It belongs to the class of androgen receptor inhibitors.
Enzalutamide is also used in the management of metastatic castration-sensitive prostate cancer (mCSPC), a type of prostate cancer that responds to testosterone-lowering treatments.
Side effects of Enzalutamide
Weakness or fatigue
Back pain
Hot flashes
Constipation
Joint pain
How Enzalutamide works
Enzalutamide is an androgen receptor inhibitor. It works by specifically targeting proteins called androgen receptors in prostate cancer cells. These receptors are sites that androgens (male hormones like testosterone) bind to, which stimulates the growth of cancer cells.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Enzalutamide can be taken orally (capsules).
Age and Dose Restrictions
This medicine is meant for adult men only.
Contraindications
Enzalutamide is contraindicated in patients who have known hypersensitivity to Enzalutamide or any of the ingredients in the capsules.
Other Medications to Avoid
Enzalutamide may interact with antibiotics (such as rifampin and clarithromycin), seizure medicines (like carbamazepine and phenytoin), and antifungal medicines (including itraconazole and ketoconazole).
Overdose and Missed Dose
An overdose of Enzalutamide may cause severe side effects, such as seizures and a brain disorder known as posterior reversible encephalopathy syndrome (PRES). Obtain immediate medical help if you suspect an overdose.
If you miss a dose of Enzalutamide, take it as soon as you remember. But if it is nearly time for your next dose, skip the missed one. Do not take a double dose to compensate for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids may help manage constipation.
Resting or doing light physical activity can help manage fatigue.
If the medicine causes dizziness, avoid fast movements and stand up slowly from a sitting or lying position.
Use in Driving and Operating Machinery
Enzalutamide may affect your ability to drive or operate heavy machinery, as this medication can cause fatigue, dizziness, and seizures.
Use in Pregnancy and Lactation
Enzalutamide is not indicated for females; it may cause harm during pregnancy and has been found to pass into animal milk.
Caution in Other Conditions
Patients with a history of seizures, brain injury, stroke, or brain tumours should exercise caution when taking this medicine.
Patients with heart disease, diabetes, high blood pressure, high cholesterol, or osteoporosis should also consult their doctor before starting this medicine.
Special Dietary and Lifestyle Recommendations
Drinking plenty of fluids can help minimise the risk of constipation associated with Enzalutamide.
Limiting salt intake can help control high blood pressure caused by this medicine.
Regular monitoring of blood glucose levels is advised for those with diabetes.
Regular heart check-ups are advised for those with heart conditions.
Frequently asked questions
Is Enzalutamide a chemotherapy medication?
Enzalutamide is not a chemotherapy medication. It is a targeted therapy that specifically blocks androgen receptors on cancer cells, thus preventing them from stimulating the growth of prostate cancer cells.
Can Enzalutamide impact sleep?
Individual responses to medication can vary. If you notice any significant changes in your sleep pattern after starting this medicine, you should consult with your doctor.
How long does it take for Enzalutamide to work?
The time it takes for Enzalutamide to work will vary depending on various factors, including the stage of the disease and the individual's overall health condition.
What is the best time to take Enzalutamide?
Enzalutamide can be taken at any time of the day, with or without food. The most important aspect is consistency in taking the medicine around the same time every day.
What precautions should I take before starting Enzalutamide treatment?
Before starting Enzalutamide treatment, inform your doctor about all your medical conditions, especially if you have had seizures, brain injury, stroke, or brain tumours; or if you have heart disease, diabetes, high blood pressure, high cholesterol, or osteoporosis.
Can Enzalutamide affect fertility in men?
Yes, Enzalutamide may lower fertility in men. It is recommended to discuss family planning with your doctor before starting this medicine.
Will I require a prescription to get Enzalutamide?
Yes, Enzalutamide is a prescription medicine and it should be taken only under the guidance and supervision of a registered medical practitioner.
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