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Esomeprazole + Naproxen

Uses of Esomeprazole + Naproxen

  • Esomeprazole + Naproxen is primarily used in the management of inflammatory conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. This medication belongs to the class of proton pump inhibitors and NSAIDs.

  • Additionally, it is also used to decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.

Side effects of Esomeprazole + Naproxen

  • Gastritis

  • Nausea

  • Diarrhoea

  • Constipation

  • Abdominal pain

How Esomeprazole + Naproxen works

  • Esomeprazole + Naproxen is an anti-inflammatory and gastroprotective combination medicine.

  • Esomeprazole is a proton pump inhibitor. It works by suppressing gastric acid secretion in the stomach. This is achieved by inhibiting the H+/K+-ATPase enzyme system, often referred to as the "acid pump", found in the stomach's parietal cells, which helps prevent gastric ulcers caused by Naproxen.

  • Naproxen is a nonsteroidal anti-inflammatory medicine (NSAID) with analgesic, anti-inflammatory and antipyretic properties. It functions by inhibiting the cyclooxygenase (COX) enzymes, reducing the synthesis of prostaglandins which are key players in causing inflammation, pain and fever.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Esomeprazole + Naproxen can be taken orally (tablet).

Age and Dose Restrictions

  • This medicine is meant for adults only.

Contraindications

  • Esomeprazole + Naproxen is contraindicated in patients with known hypersensitivity to any component of the formulation, aspirin, or other NSAIDs.

  • It is also contraindicated in patients with a history of ulcer disease or gastrointestinal bleeding.

Other Medications to Avoid

  • This combination may interact with several medications, including other nonsteroidal anti-inflammatory agents (NSAIDs) (such as ibuprofen), anticoagulants (like warfarin), and medications that affect stomach acidity (such as antacids or H2 blockers like ranitidine).

Overdose and Missed Dose

  • An overdose of Esomeprazole + Naproxen may result in symptoms like dizziness, rapid heart rate, nausea, vomiting, and sleepiness. If these symptoms occur, it is important to seek immediate medical assistance.

  • If you miss a dose of Esomeprazole + Naproxen, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Adjusting the timing of the medication may help reduce side effects like stomach upset.

  • Drinking plenty of water can help alleviate some gastrointestinal side effects such as constipation or dry mouth.

Use in Driving and Operating Machinery

  • Esomeprazole + Naproxen may cause dizziness or drowsiness. You are advised to avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

  • Esomeprazole + Naproxen should not be used during pregnancy and lactation unless specifically advised by your doctor due to potential risks to the developing fetus or nursing infant.

Caution in Other Conditions

  • Patients with severe renal or hepatic impairment should exercise caution when taking Esomeprazole + Naproxen.

  • Patients with moderate or severe renal insufficiency should not use the medicine.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, and whole grains which can help manage inflammation associated with conditions like rheumatoid arthritis.

  • Limit consumption of sugary and high-fat foods to help manage weight and reduce potential strain on joints affected by osteoarthritis.

  • Engage in regular physical activity adapted to your condition to enhance joint flexibility and reduce stiffness.

  • Avoid smoking and limit alcohol consumption as these can aggravate inflammation and interfere with the effectiveness of your medication.

Frequently asked questions

No, Esomeprazole + Naproxen is not a steroid. It is a combination of two different medicines: Esomeprazole, which is a proton pump inhibitor, and Naproxen, which is a nonsteroidal anti-inflammatory medicine. It helps in managing pain and inflammation while protecting the stomach from ulcers.

Esomeprazole + Naproxen does not directly affect the menstrual cycle. However, if you experience any changes in your menstrual cycle while taking this medicine, it is advised to consult your doctor.

The suitability of Esomeprazole + Naproxen for vegans or vegetarians depends on the ingredients used in the specific brand of the medicine. It is recommended to check the packaging or consult your pharmacist for this information.

This medication should be used with caution in people with asthma as it may cause bronchospasm (tightening of muscles that line the airways). If you have asthma, discuss this with your doctor before starting this medication.

Alcohol can increase the risk of stomach ulcers and bleeding, a potential side effect of Naproxen. Therefore, it is advisable to avoid or limit alcohol consumption while taking this medication.

One of the possible side effects of Esomeprazole + Naproxen is drowsiness. If you feel excessively drowsy after taking this medication, consult your doctor.

Esomeprazole + Naproxen can cause side effects like dizziness and drowsiness which may impair your ability to drive or operate machinery. It is advised not to drive or operate machinery until you know how this medication affects you.

Terms & Conditions


Available medicines for ESOMEPRAZOLE + NAPROXEN
Espra Xn 375/20 MG Tablet 10
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Espra Xn 500/20 MG Tablet 10
Espra Xn 500/20 MG Tablet 10
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₹108.16
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Naprosyn Es 500/20 MG Tablet 10
Naprosyn Es 500/20 MG Tablet 10
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Pack of 10 Units
₹98.40
MRP ₹120.00
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