Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Dosage Forms Available

• Ethambutol + Isoniazid + Pyrazinamide + Rifampicin is available in tablet and capsule forms for oral administration.

Age and Dose Restrictions

• This medication is suitable for adults and children above the age of 6 years.

Contraindications

• Ethambutol + Isoniazid + Pyrazinamide + Rifampicin is contraindicated in patients with severe liver disease, acute gout, or a previous hypersensitivity reaction to any of the component medicines.

Other Medications to Avoid

• Ethambutol + Isoniazid + Pyrazinamide + Rifampicin may interact with anticonvulsants (such as phenytoin), antifungals (like ketoconazole), corticosteroids (such as prednisone), HIV medicines (like zidovudine) and anticoagulants (like warfarin).

Overdose and Missed Dose

• Overdose of this combination medicine can result in serious side effects such as vomiting, liver damage, visual disturbances, and severe skin reactions. If an overdose occurs, seek immediate medical attention.

• If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearing the time for your next dose, skip the missed dose. Do not double dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water may help minimise gastrointestinal side effects like nausea and vomiting.

• Taking this medication with food may help reduce stomach upset.

Use in Driving and Operating Machinery

• This medication may cause dizziness or blurred vision. Avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

• Ethambutol + Isoniazid + Pyrazinamide + Rifampicin should be used during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Always consult your doctor.

Caution in Other Conditions

• Caution should be exercised when using this medication in patients with pre-existing liver disease, kidney disease, gout, diabetes, HIV infection, and alcoholism.

Special Dietary and Lifestyle Recommendations

• Rest and sleep as much as possible to help your body recover.

• Adherence to prescribed therapy is crucial for successful treatment of TB. Do not miss your doses and take the medication exactly as directed by your doctor.