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Flunarizine + Propranolol

Uses of Flunarizine + Propranolol

  • Flunarizine + Propranolol is primarily used for the prevention of migraines. It belongs to the class of medications known as selective calcium channel blockers and non-selective beta blockers.

Side effects of Flunarizine + Propranolol

  • Drowsiness

  • Fatigue

  • Weight gain

  • Nausea

  • Dizziness

How Flunarizine + Propranolol works

  • Flunarizine is a selective calcium channel blocker. By blocking calcium channels, it stabilises neurons and increases the threshold for migraine activation, thereby preventing excessive firing of nerve cells. It also has antihistamine properties, which inhibit serotonin release, a substance involved in triggering migraines.

  • Propranolol is a non-selective beta blocker. It competitively blocks beta-adrenergic receptors, decreasing heart rate, cardiac activity, and output. This reduces the dilation of blood vessels in the brain and modulates pain pathways, helping in managing migraine.

Certified content

Written By

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Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Flunarizine + Propranolol is available in the form of oral capsules and tablets.

Age and Dose Restrictions

  • This medicine is intended for use by adults only.

Contraindications

  • Flunarizine + Propranolol is contraindicated in patients with hypersensitivity to either flunarizine or propranolol.

  • It is also contraindicated in individuals with bradycardia (slow heart rate), heart block, cardiac failure, bronchial asthma, severe peripheral arterial disease (abnormal narrowing of the arteries), significant liver or kidney impairment, Parkinson's disease, and a history of depression.

Other Medications to Avoid

  • This combination may interact with other antihypertensives (e.g., lisinopril, metoprolol) diuretics (e.g., hydrochlorothiazide, furosemide), antiarrhythmics (e.g., lidocaine, amiodarone), antidepressants including SSRIs (e.g., fluoxetine) and tricyclic antidepressants (e.g., amitriptyline), antipsychotics (e.g., chlorpromazine, haloperidol), sedatives (e..g, diazepam), opioids (e.g., morphine and fentanyl), oral hypoglycaemics (e..g, glipizide, metformin), and NSAIDs (e..g, naproxen and ibuprofen).

Overdose and Missed Dose

  • An overdose of Flunarizine + Propranolol can lead to severe bradycardia (slow heart rate), hypotension (low blood pressure), bronchospasm, and cardiac arrest. Symptoms might include profound dizziness, fainting, trouble breathing, and extreme weakness. Emergency medical care is crucial in cases of suspected overdose.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If experiencing drowsiness or sedation, consider taking the medication at bedtime.

  • For dry mouth, increase fluid intake throughout the day.

Use in Driving and Operating Machinery

  • This medicine might cause drowsiness or dizziness. If affected, you should avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Flunarizine + Propranolol should be used during pregnancy and breastfeeding only if clearly needed. It is important to discuss the risks and benefits with your doctor before taking this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Individuals with liver issues should be cautious when using Flunarizine + Propranolol due to its extensive hepatic metabolism. Those with kidney impairments must also exercise caution due to altered medicine clearance, which might require dose adjustment.

Special Dietary and Lifestyle Recommendations

  • Maintain a consistent routine with your medication timing to avoid triggering migraine episodes.

  • Avoid known dietary triggers for migraines which might include aged cheeses, red wine, chocolate, or processed foods containing nitrates or monosodium glutamate.

  • Stress management techniques such as meditation or biofeedback may be beneficial in managing stress-related migraine triggers.

Frequently asked questions

No, Flunarizine + Propranolol is not a steroid. This medicine is a combination of two active ingredients: flunarizine, a selective calcium channel blocker, and propranolol, a non-selective beta blocker. It is primarily used for the prevention of migraines.

Flunarizine + Propranolol can potentially cause drowsiness or sedation. This in turn can affect your sleep patterns. These are common side effects and if they persist or worsen, please consult your doctor immediately.

There is no specific data available regarding the effect of Flunarizine + Propranolol on fertility. If you are planning to conceive or have concerns about fertility, please discuss them with your doctor.

There are no specific food restrictions while taking Flunarizine + Propranolol. However, you should avoid alcohol and grapefruit products as they can interfere with the medication's effectiveness.

Flunarizine + Propranolol is usually taken as prescribed by your doctor for optimal results in preventing migraines.

The onset of action for this medication may vary among individuals. However, it may take 2-3 months to see the full benefits of this medication in preventing migraines.

The usual recommended dose, timing and duration of Flunarizine + Propranolol is decided by your doctor, who will prescribe you based on the severity of your medical condition.

Terms & Conditions


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