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Folic Acid + Methylcobalamin

Uses of Folic Acid + Methylcobalamin

  • Folic Acid + Methylcobalamin is primarily used to prevent or treat deficiencies of these essential B vitamins. It belongs to the group of essential nutritional supplements.

  • This combination can also be employed in the management of conditions such as anaemia due to folate or B12 deficiency, high homocysteine levels, peripheral neuropathy, cognitive decline in the elderly, and as a preventative measure against neural tube defects during pregnancy.

Side effects of Folic Acid + Methylcobalamin

  • Nausea

  • Loss of appetite

  • Bloating

  • Gas

  • Sleep disturbances

How Folic Acid + Methylcobalamin works

  • Folic Acid + Methylcobalamin is a combination of essential B vitamins.

  • Folic Acid, also known as vitamin B9, aids in the production and maintenance of new cells. It plays a vital role in DNA synthesis, the formation of red blood cells, and foetal development. Folic acid also assists in preventing changes to DNA that could lead to cancer.

  • Methylcobalamin is a form of vitamin B12 that is crucial for the proper function and development of the brain, nerves, and blood cells. It affects the metabolism of every cell in our body, particularly regarding DNA synthesis and the metabolism of fatty acids and amino acids. Importantly, Methylcobalamin cooperates with Folic Acid to regulate the homocysteine levels in our blood.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Folic Acid + Methylcobalamin is available in several dosage forms including oral tablets, capsules, liquid, and sublingual tablets for dissolving under the tongue.

  • Additionally, this combination can be administered via intramuscular injection, which is given directly into a muscle by a healthcare provider.

Age and Dose Restrictions

  • This medicine is suitable for adults and is generally safe for use by children under medical supervision. Specific advice regarding the use in young children should be sought from a doctor.

Contraindications

  • Folic Acid + Methylcobalamin is contraindicated in patients with known hypersensitivity or allergic reactions to any components of the formulation.

  • It is also contraindicated in individuals with untreated vitamin B12 deficiency anaemia.

  • Patients with certain types of anaemia not caused by folate deficiency should avoid this medication.

  • It should not be used by individuals with active malignancy unless they are under close medical supervision.

Other Medications to Avoid

  • This combination may interact with folate antagonists (such as methotrexate), anticonvulsants (including phenytoin), proton pump inhibitors and H2 blockers (like omeprazole and ranitidine), agents affecting bile acid-like cholestyramine, diabetes medication (such as metformin), and those undergoing nitrous oxide anaesthesia.

Overdose and Missed Dose

  • An overdose of Folic Acid + Methylcobalamin may result in increased body symptoms such as a bitter taste in the mouth, sleep disturbances, or rarely, allergic reactions. If you suspect an overdose, it is essential to seek medical advice promptly.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If experiencing nausea or loss of appetite, try taking the medicine with or immediately after food.

  • In case of bloating or gas, consider spreading out doses throughout the day rather than taking it all at once.

Use in Driving and Operating Machinery

  • Folic Acid + Methylcobalamin does not usually affect your ability to drive or operate machinery. However, individuals experiencing side effects like sleep disturbances should exercise caution.

Use in Pregnancy and Lactation

  • Folic Acid + Methylcobalamin is considered safe during pregnancy and is actually recommended to prevent neural tube defects. It is also safe during lactation. However, always consult your doctor before starting any new medication during these periods.

Caution in Other Conditions

  • Individuals with liver disease or kidney disease should use Folic Acid + Methylcobalamin with caution. Monitoring by a healthcare provider is advised to adjust dosages accordingly if necessary.

Special Dietary and Lifestyle Recommendations

  • Incorporate foods rich in natural folate and vitamin B12 into your diet. Good sources include leafy green vegetables, fruits, nuts, beans, peas, dairy products, poultry, meat, eggs, and fish.

  • Moderation in alcohol consumption is advisable as excessive alcohol can interfere with the absorption of these vitamins.

  • Ensure consistent dietary practices to help maintain steady levels of these essential nutrients which are crucial for optimal health.

Frequently asked questions

Yes, Folic Acid + Methylcobalamin are B vitamins that support cellular energy production. They can improve symptoms of weakness and fatigue caused by a deficiency of these vitamins.

It is possible, although rare, to have an allergic reaction to any medication, including Folic Acid + Methylcobalamin. If you experience symptoms like hives, difficulty breathing, or swelling of your face, lips, tongue, or throat after taking this medication, seek medical help right away.

You might start noticing improvement in your symptoms within a few weeks of starting the medication. However, the full effects might take up to 1-3 months to become noticeable.

Yes, this combination can be taken by vegans. It is particularly useful because vitamin B12 is primarily found in animal products. Hence, supplementing with B12 may be necessary for those following a vegan diet.

While it is generally acceptable to take this supplement with or without food, please follow the specific instructions provided by your doctor or the supplement label.

Yes, in addition to treating vitamin deficiencies, this combination can also be used for managing conditions like peripheral neuropathy and high homocysteine levels. However, always consult your doctor before using it for these purposes.

It is generally safe to stop taking this supplement. However, doing so might cause your symptoms to return if your body still needs the vitamins. Always discuss with your doctor before making any changes to your medication routine.

Terms & Conditions


Folic Acid + Methylcobalamin in other salts

ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEASCORBIC ACID + BIOTIN + CALCIUM PANTOTHENATE + FOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + RIBOFLAVIN + THIAMINE MONONITRATE + ZINC SULPHATEASCORBIC ACID + ELEMENTAL MANGANESE + ELEMENTAL SELENIUM + ELEMENTAL ZINC + FOLIC ACID + NIACINAMIDE + PYRIDOXINE HYDROCHLORIDE + RIBOFLAVIN / VITAMIN B2 + VITAMIN A + VITAMIN EBIOTIN + CYANOCOBALAMIN / VITAMIN B12 + ELEMENTAL CHROMIUM + ELEMENTAL COPPER + ELEMENTAL MANGANESE + FOLIC ACID + GRAPE SEED EXTRACT + IODINE + MAGNESIUM + RIBOFLAVIN / VITAMIN B2 + SELENIUM + THIAMINE / VITAMIN B1 + VITAMIN A / RETINOL + VITAMIN B3 / NIACIN + VITAMIN B5 / PANTOTHENIC ACID + VITAMIN B6 / PYRIDOXINE + VITAMIN C / ASCORBIC ACID + VITAMIN D3 (CHOLECALCIFEROL) + VITAMIN E + ZINCCALCIUM PHOSPHATE + COPPER SULPHATE PENTAHYDRATE + CYANOCOBALAMIN / VITAMIN B12 + D-PANTHENOL + FOLIC ACID + LIGHT MAGNESIUM OXIDE + NICOTINAMIDE + POTASSIUM IODIDE + VITAMIN A + VITAMIN B1 + VITAMIN B2 + VITAMIN D3 (CHOLECALCIFEROL) + ZINC SULPHATE MONOHYDRATECHROMIUM PICOLINATE + CYANOCOBALAMIN + ELEMENTAL SELENIUM + FOLIC ACID + NICOTINAMIDE + PYRIDOXINE HYDROCHLORIDE + ZINC SULPHATE MONOHYDRATEELEMENTAL CALCIUM + L-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)METHYLCOBALAMIN + PREGABALINFERROUS ASCORBATE + FOLIC ACIDFOLIC ACIDRIBOFLAVIN + PYRIDOXINE + VITAMIN B12 + NIACINAMIDE + CALCIUM + FOLIC ACID + BIOTIN + ASCORBIC ACIDMETHYLCOBALAMINL METHYL FOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEPREGABALIN + NORTRIPTYLINE + METHYLCOBALAMINGABAPENTIN + METHYLCOBALAMINBIOTIN + FOLIC ACIDALFACALCIDOL + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + ELEMENTAL BORON + ELEMENTAL CALCIUM + FOLIC ACID + METHYLCOBALAMINCARBONYL IRON + FOLIC ACID + ZINC SULPHATEL METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEFOLIC ACID + IRON + ZINCDOCOSAHEXAENOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)DULOXETINE + METHYLCOBALAMINCARBONYL IRON + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + ZINC SULPHATEALPHA LIPOIC ACID + BENFOTIAMINE + ELEMENTAL CHROMIUM + INOSITOL + METHYLCOBALAMINFOLIC ACID + IRONCYANOCOBALAMIN / VITAMIN B12 + ELEMENTAL IRON + FOLIC ACID + VITAMIN C / ASCORBIC ACID + ZINCDOCOSAHEXAENOIC ACID + FOLIC ACIDCYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATECYANOCOBALAMIN / VITAMIN B12 + ELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACIDFOLIC ACID + NIACINAMIDE + RIBOFLAVIN / VITAMIN B2ALPHA LIPOIC ACID + METHYLCOBALAMIN + PREGABALINALPHA LIPOIC ACID + GABAPENTIN + METHYLCOBALAMINFOLIC ACID + VITAMIN B6 / PYRIDOXINEELEMENTAL IRON + FOLIC ACID + VITAMIN C / ASCORBIC ACIDELEMENTAL IRON + FOLIC ACID + GLYCINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE MONONITRATE + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + ELEMENTAL CHROMIUM + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENOMETHIONINE + ZINC MONOMETHIONINEELEMENTAL IRON + FOLIC ACIDALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)BIOTIN + CALCIUM PANTOTHENATE + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + NIACINAMIDE + RIBOFLAVIN / VITAMIN B2 + THIAMINE / VITAMIN B1 + VITAMIN B6 / PYRIDOXINE + VITAMIN C / ASCORBIC ACIDALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM POLYNICOTINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENIUM DIOXIDEELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACIDADENOSYLCOBALAMIN + CARBONYL IRON + FOLIC ACID + ZINC SULPHATEFERROUS FUMARATE + FOLIC ACIDALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + LACTIC ACID BACILLUSALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)CITICOLINE + METHYLCOBALAMINCYANOCOBALAMIN / VITAMIN B12 + ELEMENTAL IRON + FOLIC ACID + VITAMIN C / ASCORBIC ACIDELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACID + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DHA / DOCOSAHEXAENOIC ACID + EPA / EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + L METHYLFOLATE + MAGNESIUM + METHYLCOBALAMIN + VITAMIN K27 + ZINCALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)FERROUS ASCORBATE + FOLIC ACID + ZINC SULPHATECYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + NICOTINAMIDECYANOCOBALAMIN / VITAMIN B12 + FERRIC AMMONIUM CITRATE + FOLIC ACIDCYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + NIACINAMIDE + VITAMIN C / ASCORBIC ACIDMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN C / ASCORBIC ACIDD-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDEMETHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 (PYRIDOXINE)D-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 (PYRIDOXINE)CYANOCOBALAMIN + ELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACIDCYANOCOBALAMIN + FERRIC AMMONIUM CITRATE + FOLIC ACIDCYANOCOBALAMIN + ELEMENTAL IRON + FOLIC ACIDFERROUS ASCORBATE + FOLIC ACID + METHYLCOBALAMINELEMENTAL ZINC + FERROUS ASCORBATE + FOLIC ACIDEPALRESTAT + METHYLCOBALAMINAMITRIPTYLINE + METHYLCOBALAMINDOXYLAMINE + FOLIC ACID + VITAMIN B6 / PYRIDOXINEFOLIC ACID + L-CARNITINE / LEVOCARNITINE + METHYLCOBALAMINMETFORMIN + METHYLCOBALAMINCALCIUM-5 METHYLTETRAHYDROFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEELEMENTAL CALCIUM + FOLIC ACID + VITAMIN D3 (CHOLECALCIFEROL)D CHIRO INOSITOL + L-METHYLFOLATE + METFORMIN + METHYLCOBALAMIN + MYO INOSITOLFOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEL-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEFERROUS ASCORBATE + FOLIC ACID + ZINC SULPHATE MONOHYDRATEFOLIC ACID + LACTIC ACID BACILLUS + NIACINAMIDE + RIBOFLAVIN / VITAMIN B2FERROUS BISGLYCINATE + FOLIC ACID + METHYLCOBALAMIN + ZINC BISGLYCINATECALCIUM CITRATE + FOLIC ACID + VITAMIN D3 (CHOLECALCIFEROL)DEHYDROEPIANDROSTERONE + FOLIC ACID + VITAMIN D3 (CHOLECALCIFEROL)DIACEREIN + GLUCOSAMINE SULFATE POTASSIUM CHLORIDE + METHYL SULFONYL METHANE + METHYLCOBALAMINDOXYLAMINE + FOLIC ACID + VITAMIN B6 (PYRIDOXINE)BORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + FOLIC ACID + METHYLCOBALAMIN + OMEGA 3 FATTY ACIDALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)
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