Frusemide + Spironolactone
DIURETICUses of Frusemide + Spironolactone
- Furosemide + Spironolactone is used to remove excess water from the body by promoting urine production (diuresis).
- It helps reduce fluid retention in conditions such as heart failure, liver cirrhosis, and kidney disorders.
- Additionally, this combination helps maintain proper potassium levels in the bloodstream, which is crucial for preventing hypokalemia (low potassium levels).
Side effects of Frusemide + Spironolactone
- Dehydration
- Electrolyte imbalance
- Hypovolaemia
- Breast enlargement in male
- Menstrual irregularities
How Frusemide + Spironolactone works
- Frusemide works as a diuretic; it removes the excess salts and water from the body through passing urine, and over time, it also helps in blood vessel relaxation. However, there is potassium salt loss on intake of frusemide.
- Spironolactone works as a diuretic but with no potassium loss from the body.
- This balancing and coordination of two medicines helps in resistant edema.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Frusemide + Spironolactone can be taken orally (tablet).
Age And Dose Restrictions
- This combination is intended to be used for adults. It is not recommended for children.
Contraindications
- This combination is contraindicated in patients with a history of hypersensitivity to frusemide or spironolactone, in patients with dehydration or hypovolaemia, impaired renal function and a creatinine clearance below 30 ml/min per 1.73 metre square body surface area, acute renal failure, or anuria, hyperkalaemia, hypokalaemia, and severe hyponatraemia.
Medications To Avoid With This Drug
- Medications such as antihypertensives (metoprolol), NSAIDs (aspirin), diuretics (chlorthalidone), hypnotics (chloral hydrate), aminoglycosides (gentamicin), antacids (sucralfate), antimanic agents (lithium), ACE inhibitors (captopril), antipsychotics (risperidone), hormones (levothyroxine) are not recommended to be used with this combination. These medications may alter the safety and effectiveness of this combination.
- Avoid the concomitant use of medications such as uricosurics (probenecid), antimetabolites (methotrexate), anticonvulsants (phenytoin), corticosteroids (prednisone), ulcer medications (carbenoxolone), sympathomimetic agents (epinephrine), bronchodilators (theophylline), and cardiac medications (digoxin). These medications may alter the safety and effectiveness of this combination.
Overdose And Missed Dose
- Overdose of this combination can lead to hypovolaemia, dehydration, haemoconcentration, cardiac arrhythmias due to excessive diuresis. It can lead to symptoms such as severe hypotension (leading to shock), acute renal failure, thrombosis, delirious states, flaccid paralysis, apathy and confusion. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
- If you miss a dose of this combination, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.
Management Of Side Effects
- Side effects like a drastic fall in blood pressure may make it difficult to focus and pay attention to activities like driving and the use of machinery. Do not drive and operate the machine when you are unstable. Resume your activities after you feel better.
Use In Driving And Operating Machinery
- It is unlikely to impair the mental alertness or coordination required while driving.
Use In Pregnancy And Lactation
- This combination is not recommended for pregnant and breastfeeding women.
Caution In Other Conditions
- Caution is advised if this combination is used in elderly patients. Special care is advised for liver, kidney, and heart diseases. Please consult your doctor before using this medicine.
Special Dietary And Lifestyle Recommendation
- The use of alcohol is not recommended with this combination.
- It should be used in the morning so you will not have a disturbed sleep getting up to go to urinate.
Frequently asked questions
1. Does Frusemide + Spironolactone cause any voice changes?
Yes, this combination may cause voice changes upon use. People who are in the profession where talking and expressing through talk should be cautious about its use.
2. What are the possible medicine interactions of Frusemide + Spironolactone?
This combination may interact with medications such as antihypertensives (metoprolol), NSAIDs (aspirin), diuretics (chlorthalidone), hypnotics (chloral hydrate), aminoglycosides (gentamicin), antacids (sucralfate), antimanic agents (lithium), ACE inhibitors (captopril), antipsychotics (risperidone), hormones (levothyroxine), uricosurics (probenecid), antimetabolites (methotrexate), anticonvulsants (phenytoin), corticosteroids (prednisone), ulcer medications (carbenoxolone), sympathomimetic agents (epinephrine), bronchodilators (theophylline), and cardiac medications (digoxin).
3. What are the possible disease interactions of Frusemide + Spironolactone?
This combination may interact in patients with dehydration or hypovolaemia, impaired renal function and a creatinine clearance below 30 ml/min per 1.73 metre square body surface area, acute renal failure, or anuria, hyperkalaemia, hypokalaemia, and severe hyponatraemia.
4. Is it safe to use Frusemide + Spironolactone for liver disease patients?
No, this combination is not recommended for liver disease patients.
5. Is it safe to use Frusemide + Spironolactone in kidney disease patients?
No, this combination is not recommended for kidney disease patients.
6. What are the symptoms of the overdosage of Frusemide + Spironolactone?
Overdose of this combination can lead to symptoms such as severe hypotension (leading to shock), acute renal failure, thrombosis, delirious states, flaccid paralysis, apathy and confusion.
Frusemide + Spironolactone in other salts
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