Glimepiride + Metformin + Sitagliptin

Dosage Forms Available

• Glimepiride + Metformin + Sitagliptin is available for oral use in the form of tablets.

Age and Dose Restrictions

• This combination medicine is intended for use in adults. It is not recommended for children or adolescents.

Contraindications

• Glimepiride + Metformin + Sitagliptin is contraindicated in patients with type 1 diabetes or diabetic ketoacidosis.

• It is also contraindicated in patients with known allergy to any of the three active ingredients.

Other Medications to Avoid

• Glimepiride + Metformin + Sitagliptin may interact with carbonic anhydrase inhibitors (such as acetazolamide and dichlorphenamide), strong CYP2C8 inhibitors (such as gemfibrozil), and medications that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir).

• It is crucial to consult a doctor before starting any prescription or over-the-counter medications.

Overdose and Missed Dose

• An overdose of this combination medicine may lead to symptoms such as hypoglycaemia, lactic acidosis, severe nausea, vomiting or diarrhoea. If you suspect an overdose, seek medical help immediately.

• If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not double-dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience severe side effects or worsening symptoms, please consult your doctor.

• Drinking plenty of water can help manage some gastrointestinal side effects, such as nausea and diarrhoea.

• This medicine is known to cause hypoglycaemia. Regular monitoring of blood glucose levels can help prevent low blood sugar episodes.

Use in Driving and Operating Machinery

• Glimepiride, metformin, and sitagliptin may cause dizziness or drowsiness. If you experience these side effects, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• Consult your doctor before using this medicine if you are pregnant or breastfeeding. The safety of this medicine during pregnancy and lactation has not been established.

Caution in Other Conditions

• Patients with kidney impairment, liver impairment or congestive heart failure should exercise caution when taking this medicine.

• Regular monitoring of kidney function is recommended in these patients.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet to help manage blood sugar levels effectively. Limit intake of foods high in sugar and saturated fats.

• Regular physical activity can help manage blood sugar levels and overall health. Aim for at least 150 minutes of moderate-intensity exercise a week.

• Limit alcohol consumption as it can affect blood sugar control and increase the risk of lactic acidosis when taking this medicine.

• Regularly monitor your blood sugar levels and share the results with your doctor. This can help your doctor determine how well the medicine is working.