Glipizide + Metformin

Dosage Forms Available

• Glipizide + Metformin is available for use via the oral route in the form of tablets.

Age and Dose Restrictions

• This combination is generally recommended for adults and children above 10 years of age to manage their type 2 diabetes.

Contraindications

• Glipizide + Metformin is contraindicated in patients with known allergies to either metformin or glipizide.

• It is also contraindicated in patients with diabetic ketoacidosis, severe kidney disease, and metabolic acidosis.

Other Medications to Avoid

• This combination can interact with diuretics (e.g., metolazone and hydrochlorothiazide), corticosteroids (e.g., betamethasone and prednisone), thyroid medications (e.g., levothyroxine sodium), oestrogens and oral contraceptives (e.g., ethinylestradiol and norethindrone), and calcium channel blockers (e.g., isradipine and nisoldipine).

Overdose and Missed Dose

• An overdose of Glipizide + Metformin can cause lactic acidosis and severe hypoglycemia. This requires immediate medical attention.

• If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Never take a double dose to make up for a missed one.

Management of Side Effects

Most side effects of Glipizide + Metformin are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water can help manage diarrhoea and other stomach-related side effects.

• Taking the medicine with food can help prevent nausea and upset stomachs.

Use in Driving and Operating Machinery

• Glipizide + Metformin does not usually affect your ability to drive or operate machinery. However, if you experience dizziness or other side effects that could impair your judgement or coordination, avoid these activities.

Use in Pregnancy and Lactation

• Consult your doctor before using Glipizide + Metformin in pregnancy and breastfeeding, as it may not be safe.

Caution in Other Conditions

• Patients with kidney disease or congestive heart failure should exercise caution when taking Glipizide + Metformin. Careful monitoring and dose adjustment may be required.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet rich in fruits, vegetables, lean protein, and whole grains to help manage blood sugar levels.

• Regular physical activity, such as walking or cycling, can also help manage blood sugar levels.

• Monitoring your blood sugar levels regularly can help you keep track of any changes and adjust your treatment plan accordingly.

• Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis with metformin.