Glipizide + Metformin
Uses of Glipizide + Metformin
Glipizide + Metformin is primarily used to manage type 2 diabetes in adults and belongs to a class of antidiabetic medications called sulfonylureas and biguanides.
Side effects of Glipizide + Metformin
Hypoglycaemia (low blood sugar)
Diarrhoea
Nausea and vomiting
Abdominal pain
Rash or itching
How Glipizide + Metformin works
Glipizide + Metformin is an antidiabetic combination.
Glipizide is sulfonylurea. It stimulates the pancreas to secrete more insulin, a hormone that controls blood sugar levels by moving sugar from the blood into the cells, where it is utilised for energy.
Metformin is a biguanide. It reduces the amount of sugar produced by the liver and enhances insulin sensitivity, thus helping the body use insulin more efficiently. It also decreases the absorption of sugar from the intestines.
Together, these two components work harmoniously to better manage high blood sugar levels in people with type 2 diabetes than either component could on its own. This dual action can prevent long-term complications such as nerve damage, blindness, kidney failure, amputations, and heart problems associated with uncontrolled diabetes.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Glipizide + Metformin is available for use via the oral route in the form of tablets.
Age and Dose Restrictions
This combination is generally recommended for adults and children above 10 years of age to manage their type 2 diabetes.
Contraindications
Glipizide + Metformin is contraindicated in patients with known allergies to either metformin or glipizide.
It is also contraindicated in patients with diabetic ketoacidosis, severe kidney disease, and metabolic acidosis.
Other Medications to Avoid
This combination can interact with diuretics (e.g., metolazone and hydrochlorothiazide), corticosteroids (e.g., betamethasone and prednisone), thyroid medications (e.g., levothyroxine sodium), oestrogens and oral contraceptives (e.g., ethinylestradiol and norethindrone), and calcium channel blockers (e.g., isradipine and nisoldipine).
Overdose and Missed Dose
An overdose of Glipizide + Metformin can cause lactic acidosis and severe hypoglycemia. This requires immediate medical attention.
If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Never take a double dose to make up for a missed one.
Management of Side Effects
Most side effects of Glipizide + Metformin are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage diarrhoea and other stomach-related side effects.
Taking the medicine with food can help prevent nausea and upset stomachs.
Use in Driving and Operating Machinery
Glipizide + Metformin does not usually affect your ability to drive or operate machinery. However, if you experience dizziness or other side effects that could impair your judgement or coordination, avoid these activities.
Use in Pregnancy and Lactation
Consult your doctor before using Glipizide + Metformin in pregnancy and breastfeeding, as it may not be safe.
Caution in Other Conditions
Patients with kidney disease or congestive heart failure should exercise caution when taking Glipizide + Metformin. Careful monitoring and dose adjustment may be required.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet rich in fruits, vegetables, lean protein, and whole grains to help manage blood sugar levels.
Regular physical activity, such as walking or cycling, can also help manage blood sugar levels.
Monitoring your blood sugar levels regularly can help you keep track of any changes and adjust your treatment plan accordingly.
Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis with metformin.
Frequently asked questions
Is Glipizide + Metformin a Steroid?
No, Glipizide + Metformin is not a steroid. It is a combination of two antidiabetic medications used to manage type 2 diabetes.
Does Glipizide + Metformin Have Any Effect on Sleep?
There is no direct evidence to suggest that Glipizide + Metformin affects sleep. However, if you experience any unusual sleep patterns or difficulties sleeping, it is best to consult your doctor.
Is It Safe to Take Glipizide + Metformin Daily?
Yes, it is safe to take Glipizide + Metformin daily as long as you follow the dosage and timing prescribed by your doctor.
How Much Time Does Glipizide + Metformin Take to Work?
The time required for Glipizide + Metformin to work may vary from person to person based on their individual response. Your doctor can provide more specific information.
What Is the Duration of Treatment with Glipizide + Metformin?
The duration of treatment with Glipizide + Metformin depends on your health condition and the doctor's assessment. Always follow the duration recommended by your doctor.
Is the Glipizide + Metformin Available Over the Counter, or Do I Need a Prescription?
Glipizide + Metformin is a prescription medication and is not available over the counter.
Are there natural alternatives to Glipizide + Metformin?
While a healthy diet and regular exercise can help manage blood sugar levels, they cannot replace the need for medication in managing type 2 diabetes. Always consult your doctor before making any changes to your treatment plan.
Glipizide + Metformin in other salts
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