The primary use of the medicine Glycopyrrolate / Glycopyrronium is in managing conditions such as general anaesthesia, peptic ulcer disease, and excessive drooling (sialorrhoea). It belongs to the group of anticholinergic medicines.
In addition to this, it can be used off-label for managing conditions such as hyperhidrosis (excessive sweating).
Dry mouth
Constipation
Drowsiness
Dizziness
Blurred vision
Urinary retention
Glycopyrrolate / Glycopyrronium is an anticholinergic medicine.
It works by inhibiting the action of acetylcholine on muscarinic receptors in the smooth muscles, secretory glands and the central nervous system. This leads to reduced secretions in the respiratory tract, decreased stomach acid production and relaxation of smooth muscles, particularly in the gastrointestinal and respiratory systems.
MSc (Applied Genetics)
BMS, FMC, MD Resident
Glycopyrrolate / Glycopyrronium is available for oral use in the form of tablets and oral solutions, which are typically used to manage conditions such as peptic ulcer disease and excessive drooling.
It is also available as an injection, which is administered either intramuscularly or intravenously, primarily in hospital settings.
This medicine is meant for adults and children. However, the age range for children depends on the specific indication for use. It is crucial to consult a doctor about age-appropriate dosing.
Glycopyrrolate / Glycopyrronium is contraindicated in patients with known hypersensitivity to the medication or its components.
Patients with narrow-angle glaucoma, myasthenia gravis, obstructive uropathy (such as enlarged prostate), or gastrointestinal obstruction (such as pyloric stenosis or paralytic ileus) should not take this medication.
Glycopyrrolate / Glycopyrronium may interact with other anticholinergic medicines (such as atropine, scopolamine), antidepressants (like fluoxetine), antipsychotics (like phenothiazines), antihistamines (like diphenhydramine), opioid analgesics (like codeine, morphine) and potassium chloride solid oral dosage forms.
An overdose of this medication may cause severe dry mouth, constipation, rapid heartbeat, and difficulty urinating. If you observe these symptoms, inform your doctor immediately.
If you miss a dose of this medicine, take it as soon as you remember. If it is close to your next dose, skip the missed dose and follow your regular dosing schedule.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For dry mouth, consider chewing sugar-free gum or sucking on ice chips.
For constipation, increase your intake of fluids and dietary fibre.
If you experience drowsiness or dizziness, avoid activities that require mental alertness such as driving or operating heavy machinery.
Glycopyrrolate / Glycopyrronium may affect your ability to drive or operate heavy machinery due to side effects like drowsiness and dizziness. Avoid such activities if these side effects occur after taking the medication.
The safety of Glycopyrrolate / Glycopyrronium use during pregnancy and breastfeeding is not well-established. It is advisable to consult your doctor before using this medication if you are pregnant or breastfeeding.
Patients with kidney diseases, Down syndrome, gastric reflux, diarrhoea, ulcerative colitis, hyperthyroidism, or high fever should exercise caution when taking Glycopyrrolate / Glycopyrronium.
Maintaining a balanced diet can help manage conditions like peptic ulcer disease for which Glycopyrrolate / Glycopyrronium is often prescribed.
Regular hydration can help manage side effects like dry mouth and constipation associated with this medication.
Avoiding triggers of excessive salivation (such as certain foods or stress) can improve the management of sialorrhea for patients taking this medication.
Frequently asked questions
No, Glycopyrrolate / Glycopyrronium is not a steroid. It is a type of medicine known as an anticholinergic.
There are no direct indications that Glycopyrrolate / Glycopyrronium affects sleep. However, if you notice any alteration in your sleep patterns after starting this medicine, please consult your doctor.
If you have concerns about fertility, it is advisable to consult your doctor.
No specific diet restrictions are known for patients taking Glycopyrrolate / Glycopyrronium. However, maintaining a balanced diet is always beneficial for overall health.
Glycopyrrolate / Glycopyrronium is a prescription medicine and is not usually available over the counter.
The onset of action of the medicine depends on the route of administration. For instance, oral formulations usually take around 30-60 minutes to start working.
The best time to take this medicine would depend upon the advice of your doctor and may be affected by factors such as your specific medical condition and other medications you are taking.
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