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Hydrochlorothiazide + Irbesartan

Uses of Hydrochlorothiazide + Irbesartan

Hydrochlorothiazide + Irbesartan is a combination medicine used to manage high blood pressure (hypertension). It combines a thiazide diuretic with an angiotensin II receptor blocker (ARB).

Hydrochlorothiazide + Irbesartan is commonly used for:

• Hypertension: Lowers high blood pressure when a single medicine alone does not provide adequate control.
• Reducing cardiovascular risk: Helps lower the risk of stroke and heart-related complications linked to uncontrolled blood pressure.
• Long-term blood pressure management: Used as an ongoing treatment to help keep blood pressure within a healthy range.

Side effects of Hydrochlorothiazide + Irbesartan

  • Dizziness

  • Fatigue

  • Headache

  • Nausea

  • Muscle pain

How Hydrochlorothiazide + Irbesartan works

Hydrochlorothiazide + Irbesartan works through two complementary actions that lower blood pressure more effectively together than either medicine alone.

Hydrochlorothiazide is a thiazide diuretic. It increases the amount of salt and water removed from the body through urine, which lowers blood volume and reduces blood pressure.

Irbesartan is an angiotensin II receptor blocker. It blocks the action of angiotensin II, a hormone that narrows blood vessels. This allows blood vessels to relax and widen, improving blood flow and further lowering blood pressure.

Together, the two medicines target blood pressure from different angles, offering more consistent control than either alone.

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Written By

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Dr Nikita LoboMedical Content Reviewer| 9 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi RoshaMedical Content Writer| 10 years

BAMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Hydrochlorothiazide + Irbesartan is accessible for oral administration in the form of tablets.

Age and Dose Restrictions

  • This medication is intended for use in adults only.

Contraindications

  • Hydrochlorothiazide + Irbesartan is contraindicated in patients with known hypersensitivity to sulfa-derived medicines.

  • It is also contraindicated in individuals with severe renal impairment or anuria (non-production of urine).

Other Medications to Avoid

  • This combination may interact with other blood pressure medications (such as beta-blockers like atenolol and metoprolol), diuretics (including furosemide and spironolactone), NSAIDs (such as ibuprofen and naproxen), lithium, potassium supplements, and insulin or oral diabetes medications (like metformin and glibenclamide).

Overdose and Missed Dose

  • Taking more than the prescribed dose may cause severe dizziness, dehydration, an imbalance of body salts, or a significant drop in blood pressure. If you suspect an overdose, seek medical attention immediately.
  • If you miss a dose of Hydrochlorothiazide + Irbesartan, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Dizziness can be managed by rising slowly from sitting or lying positions.

  • For dehydration risk due to increased urination, maintain adequate fluid intake.

Use in Driving and Operating Machinery

  • Hydrochlorothiazide + Irbesartan can cause dizziness. It is advisable to avoid driving or operating heavy machinery until you know how this medication affects you.

Use in Pregnancy and Lactation

  • Hydrochlorothiazide + Irbesartan is not recommended during pregnancy or while breastfeeding due to potential risks to the baby. Women who are pregnant or planning to become pregnant should consult their doctor before using this medication.

Caution in Other Conditions

  • Caution is advised when using Hydrochlorothiazide + Irbesartan in patients with kidney disease or liver disease as it may require dose adjustments or specific monitoring.

  • Individuals with congestive heart failure should also use this medicine cautiously.

Special Dietary and Lifestyle Recommendations

  • For effective management of hypertension, adopt a diet low in salt and sodium. Prefer fresh fruits, vegetables, whole grains, and lean proteins over processed foods high in sodium.

  • Engage in regular physical activity such as brisk walking or cycling for at least 150 minutes per week to help lower and control blood pressure.

  • Monitor your blood pressure regularly to assess the effectiveness of the medication combined with lifestyle changes.

  • Limit alcohol consumption as it can raise blood pressure and reduce the effectiveness of this medication.

  • Manage stress through relaxation techniques such as deep breathing, meditation, or yoga which can positively affect blood pressure levels.

  • Maintain a healthy body weight; even a small amount of weight loss can significantly lower high blood pressure.

Frequently asked questions

No, Hydrochlorothiazide + Irbesartan does not usually cause weight gain. However, if you notice unusual weight gain, consult your doctor.

Hydrochlorothiazide + Irbesartan is generally safe for long-term use if taken under the supervision of your doctor.

If you have diabetes, you should consult your doctor before taking Hydrochlorothiazide + Irbesartan as it may affect your blood sugar levels.

While some patients report hair loss, this side effect is not commonly associated with Hydrochlorothiazide + Irbesartan. If you notice hair loss, consult your doctor.

There are no reports of Hydrochlorothiazide + Irbesartan affecting mood or mental health. However, if you experience mood changes or mental health issues while on this medication, consult your doctor.

Hydrochlorothiazide + Irbesartan can be taken with or without food. However, it is usually recommended to take it at the same time each day.

There is no common evidence to suggest that Hydrochlorothiazide + Irbesartan impacts the menstrual cycle. If you notice changes in your cycle, consult your doctor.

Terms & Conditions


List of medicines for Hydrochlorothiazide + Irbesartan

Irovel H Tablet 10
Irovel H Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹117.75
MRP ₹147.19
20% OFF
Coaprovel 150/12.5 Mg Tablet 14
Coaprovel 150/12.5 Mg Tablet 14
Sanofi India Ltd.
Pack of 14 Units
₹195
MRP ₹243.75
20% OFF
Coaprovel 300/12.5 Mg Tablet 14
Coaprovel 300/12.5 Mg Tablet 14
Sanofi India Ltd.
Pack of 14 Units
₹240.45
MRP ₹300.56
20% OFF
Xarb H 150/12.5 MG Tablet 10
Xarb H 150/12.5 MG Tablet 10
Abbott Healthcare Pvt. Ltd
Pack of 10 Units
₹168.9
MRP ₹211.12
20% OFF
Irbetag H Tablet 10
Irbetag H Tablet 10
Ikon Remedies Pvt Ltd
Pack of 10 Units
₹146.25
MRP ₹182.81
20% OFF
Insat H Tablet 10
Insat H Tablet 10
East West Pharma
Pack of 10 Units
₹79.5
MRP ₹99.38
20% OFF

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