Hydrochlorothiazide + Lisinopril

Dosage Forms Available

• Hydrochlorothiazide + Lisinopril is available for oral administration as tablets.

Age and Dose Restrictions

• This medicine is intended for use by adults only.

Contraindications

• Hydrochlorothiazide + Lisinopril is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy.

• It is also contraindicated in patients with hypersensitivity to lisinopril, hydrochlorothiazide, or any components of the formulation.

• This medicine is contraindicated for individuals who cannot produce urine (anuria).

Other Medications to Avoid

• Hydrochlorothiazide + Lisinopril can interact with blood pressure-lowering medicines (such as amlodipine, losartan), potassium supplements (such as potassium chloride), NSAIDs (such as ibuprofen, naproxen), and diabetes medications (such as insulin, metformin). It may also interact with lithium, diuretics (such as furosemide, spironolactone), and corticosteroids (such as prednisone, dexamethasone).

Overdose and Missed Dose

• An overdose of Hydrochlorothiazide + Lisinopril may lead to severe dehydration, electrolyte imbalance, low blood pressure, and kidney failure. If you suspect an overdose, it is crucial to seek immediate medical attention.

• If you miss a dose of Hydrochlorothiazide + Lisinopril, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage dizziness or lightheadedness, try moving slowly from a sitting to a standing position.

• Stay hydrated to help mitigate effects like dry mouth or dehydration.

Use in Driving and Operating Machinery

• Hydrochlorothiazide + Lisinopril may cause dizziness or fatigue. These effects can impair your ability to drive or operate heavy machinery. It is advisable to avoid these activities if you experience such side effects.

Use in Pregnancy and Lactation

• Hydrochlorothiazide + Lisinopril is not recommended during pregnancy, especially in the second and third trimesters due to the risk of harm to the developing fetus. It is also advised to avoid this medication while breastfeeding. Consult your doctor for more information.

Caution in Other Conditions

• Caution is advised when using Hydrochlorothiazide + Lisinopril in patients with kidney or liver disease. This medicine can affect kidney function and alter liver enzyme levels.

• Patients with diabetes should monitor their blood sugar levels frequently, as this medication can affect glucose tolerance.

Special Dietary and Lifestyle Recommendations

• Maintain a low-sodium diet to enhance the effectiveness of Hydrochlorothiazide + Lisinopril in lowering blood pressure. Too much salt can cause fluid retention, which counteracts the effects of the diuretic.

• Regular physical activity helps lower blood pressure naturally and should be part of your routine unless otherwise advised by your doctor.

• It is beneficial to monitor your fluid intake to avoid dehydration especially when engaging in activities that cause excessive sweating.

• Monitor intake of potassium-rich foods or use potassium supplements only under medical advice since the combination of this medication with extra potassium can lead to dangerous levels of potassium in your blood.